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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Debomoy K. Lahiri

Laboratory of Molecular Neurogenetics

Department of Psychiatry

Institute of Psychiatric Research

Indiana University School of Medicine



Name/email consistency: high



  • Laboratory of Molecular Neurogenetics, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, USA. 2013
  • Department of Psychiatry, Indiana University School of Medicine, 791Union Drive, Indianapolis IN 46202, USA. 1998 - 2011
  • Indiana University School of Medicine, Department of Psychiatry, Institute of Psychiatric Research, Room PR-313, USA. 2003 - 2006


  1. PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE). Lahiri, D.K., Maloney, B., Rogers, J.T., Ge, Y.W. BMC. Genomics (2013) [Pubmed]
  2. The "Aged Garlic Extract:" (AGE) and One of its Active Ingredients S-Allyl-LCysteine (SAC) as Potential Preventive and Therapeutic Agents for Alzheimer's Disease (AD). Ray, B., Chauhan, N.B., Lahiri, D.K. Curr. Med. Chem. (2011) [Pubmed]
  3. Current Drug Targets for Modulating Alzheimer's Amyloid Precursor Protein: Role of Specific Micro-RNA Species. Long, J.M., Lahiri, D.K. Curr. Med. Chem. (2011) [Pubmed]
  4. Neuroprotective and neurorescue effects of a novel polymeric nanoparticle formulation of curcumin (NanoCurc™) in the neuronal cell culture and animal model: implications for Alzheimer's disease. Ray, B., Bisht, S., Maitra, A., Maitra, A., Lahiri, D.K. J. Alzheimers Dis. (2011) [Pubmed]
  5. The "LEARn" (Latent Early-life Associated Regulation) model integrates environmental risk factors and the developmental basis of Alzheimer's disease, and proposes remedial steps. Lahiri, D.K., Maloney, B. Exp. Gerontol. (2010) [Pubmed]
  6. Beyond the signaling effect role of amyloid-ß42 on the processing of APP, and its clinical implications. Lahiri, D.K., Maloney, B. Exp. Neurol. (2010) [Pubmed]
  7. The LEARn model: an epigenetic explanation for idiopathic neurobiological diseases. Lahiri, D.K., Maloney, B., Zawia, N.H. Mol. Psychiatry (2009) [Pubmed]
  8. Early-life events may trigger biochemical pathways for Alzheimer's disease: the "LEARn" model. Lahiri, D.K., Zawia, N.H., Greig, N.H., Sambamurti, K., Maloney, B. Biogerontology (2008) [Pubmed]
  9. Differential effects of two hexahydropyrroloindole carbamate-based anticholinesterase drugs on the amyloid beta protein pathway involved in Alzheimer's disease. Lahiri, D.K., Alley, G.M., Tweedie, D., Chen, D., Greig, N.H. Neuromolecular Med. (2007) [Pubmed]
  10. How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the "LEARn" model (latent early-life associated regulation) may explain the triggering of AD. Lahiri, D.K., Maloney, B., Basha, M.R., Ge, Y.W., Zawia, N.H. Curr. Alzheimer. Res (2007) [Pubmed]
  11. The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. Lahiri, D.K., Chen, D., Maloney, B., Holloway, H.W., Yu, Q.S., Utsuki, T., Giordano, T., Sambamurti, K., Greig, N.H. J. Pharmacol. Exp. Ther. (2007) [Pubmed]
  12. BACE1 gene promoter is differentially regulated: detection of a novel promoter region for its cell type-specific regulation. Lahiri, D.K., Maloney, B., Ge, Y.W. J. Mol. Neurosci. (2006) [Pubmed]
  13. Functional domains of the BACE1 and BACE2 promoters and mechanisms of transcriptional suppression of the BACE2 promoter in normal neuronal cells. Lahiri, D.K., Maloney, B., Ge, Y.W. J. Mol. Neurosci. (2006) [Pubmed]
  14. Taking down the unindicted co-conspirators of amyloid beta-peptide-mediated neuronal death: shared gene regulation of BACE1 and APP genes interacting with CREB, Fe65 and YY1 transcription factors. Lahiri, D.K., Ge, Y.W., Rogers, J.T., Sambamurti, K., Greig, N.H., Maloney, B. Current. Alzheimer. Research (2006) [Pubmed]
  15. Where the actions of environment (nutrition), gene and protein meet: beneficial role of fruit and vegetable juices in potentially delaying the onset of Alzheimer's disease. Lahiri, D.K. J. Alzheimers Dis. (2006) [Pubmed]
  16. Characterization of the APP proximal promoter and 5'-untranslated regions: identification of cell type-specific domains and implications in APP gene expression and Alzheimer's disease. Lahiri, D.K., Ge, Y.W., Maloney, B. FASEB J. (2005) [Pubmed]
  17. Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease. Lahiri, D.K., Ge, Y.W., Maloney, B., Wavrant-De Vrièze, F., Hardy, J. Neurobiol. Aging (2005) [Pubmed]
  18. Amyloid, cholinesterase, melatonin, and metals and their roles in aging and neurodegenerative diseases. Lahiri, D.K., Chen, D.M., Lahiri, P., Bondy, S., Greig, N.H. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
  19. Alzheimer's disease--current trends in basic and clinical research. Highlights from the 16th ECNP. September 20-24 2003, Prague, Czech Republic. Lahiri, D.K. Expert. Opin. Investig. Drugs (2004) [Pubmed]
  20. Age-related changes in serum melatonin in mice: higher levels of combined melatonin and 6-hydroxymelatonin sulfate in the cerebral cortex than serum, heart, liver and kidney tissues. Lahiri, D.K., Ge, Y.W., Sharman, E.H., Bondy, S.C. J. Pineal Res. (2004) [Pubmed]
  21. Dietary supplementation with melatonin reduces levels of amyloid beta-peptides in the murine cerebral cortex. Lahiri, D.K., Chen, D., Ge, Y.W., Bondy, S.C., Sharman, E.H. J. Pineal Res. (2004) [Pubmed]
  22. Apolipoprotein gene and its interaction with the environmentally driven risk factors: molecular, genetic and epidemiological studies of Alzheimer's disease. Lahiri, D.K., Sambamurti, K., Bennett, D.A. Neurobiol. Aging (2004) [Pubmed]
  23. Apolipoprotein E as a target for developing new therapeutics for Alzheimer's disease based on studies from protein, RNA, and regulatory region of the gene. Lahiri, D.K. J. Mol. Neurosci. (2004) [Pubmed]
  24. Rationale for the development of cholinesterase inhibitors as anti-Alzheimer agents. Lahiri, D.K., Rogers, J.T., Greig, N.H., Sambamurti, K. Curr. Pharm. Des. (2004) [Pubmed]
  25. Functional characterization of amyloid beta precursor protein regulatory elements: rationale for the identification of genetic polymorphism. Lahiri, D.K. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  26. Role of the APP promoter in Alzheimer's disease: cell type-specific expression of the beta-amyloid precursor protein. Lahiri, D.K., Ge, Y.W. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
  27. A critical analysis of new molecular targets and strategies for drug developments in Alzheimer's disease. Lahiri, D.K., Farlow, M.R., Sambamurti, K., Greig, N.H., Giacobini, E., Schneider, L.S. Curr. Drug. Targets (2003) [Pubmed]
  28. Role of cytokines in the gene expression of amyloid beta-protein precursor: identification of a 5'-UTR-binding nuclear factor and its implications in Alzheimer's disease. Lahiri, D.K., Chen, D., Vivien, D., Ge, Y.W., Greig, N.H., Rogers, J.T. J. Alzheimers Dis. (2003) [Pubmed]
  29. 6th International Conference on Alzheimer's Disease and Parkinson's Disease. Lahiri, D.K. Expert. Opin. Investig. Drugs (2003) [Pubmed]
  30. Does nitric oxide synthase contribute to the pathogenesis of Alzheimer's disease?: effects of beta-amyloid deposition on NOS in transgenic mouse brain with AD pathology. Lahiri, D.K., Chen, D., Ge, Y.W., Farlow, M., Kotwal, G., Kanthasamy, A., Ingram, D.K., Greig, N.H. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  31. A proximal gene promoter region for the beta-amyloid precursor protein provides a link between development, apoptosis, and Alzheimer's disease. Lahiri, D.K., Ghosh, C., Ge, Y.W. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  32. Developmental expression of the beta-amyloid precursor protein and heat-shock protein 70 in the cerebral hemisphere region of the rat brain. Lahiri, D.K., Nall, C., Chen, D., Zaphiriou, M., Morgan, C., Nurnberger, J.I. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  33. Nicotine reduces the secretion of Alzheimer's beta-amyloid precursor protein containing beta-amyloid peptide in the rat without altering synaptic proteins. Lahiri, D.K., Utsuki, T., Chen, D., Farlow, M.R., Shoaib, M., Ingram, D.K., Greig, N.H. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  34. The role of the carboxyl-terminal fragments of amyloid precursor protein in Alzheimer's disease. Lahiri, D.K., Kotwal, G.J., Farlow, M.R., Sima, A., Kupsky, W., Sarkar, F.H., Sambamurti, K. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  35. Functional characterization of the 5'-regulatory region of the murine apolipoprotein gene. Lahiri, D.K., Alley, G.M., Ge, Y.W., Du, Y. Ann. N. Y. Acad. Sci. (2002) [Pubmed]
  36. Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin. Lahiri, D.K., Ge, Y.W., Farlow, M.R. Ann. N. Y. Acad. Sci. (2000) [Pubmed]
  37. Analysis of the 5'-flanking region of the beta-amyloid precursor protein gene that contributes to increased promoter activity in differentiated neuronal cells. Lahiri, D.K., Song1, W., Ge, Y.W. Brain Res. Mol. Brain Res. (2000) [Pubmed]
  38. Electrophoretic mobility shift assay for the detection of specific DNA-protein complex in nuclear extracts from the cultured cells and frozen autopsy human brain tissue. Lahiri, D.K., Ge, Y. Brain Res. Brain Res. Protoc. (2000) [Pubmed]
  39. Melatonin affects the metabolism of the beta-amyloid precursor protein in different cell types. Lahiri, D.K. J. Pineal Res. (1999) [Pubmed]
  40. Interactions between melatonin, reactive oxygen species, and nitric oxide. Lahiri, D.K., Ghosh, C. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  41. Effect of oxidative stress on DNA damage and beta-amyloid precursor proteins in lymphoblastoid cell lines from a Nigerian population. Lahiri, D.K., Xu, Y., Klaunig, J., Baiyewu, O., Ogunniyi, A., Hall, K., Hendrie, H., Sahota, A. Ann. N. Y. Acad. Sci. (1999) [Pubmed]
  42. The secretion of amyloid beta-peptides is inhibited in the tacrine-treated human neuroblastoma cells. Lahiri, D.K., Farlow, M.R., Sambamurti, K. Brain Res. Mol. Brain Res. (1998) [Pubmed]
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