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Arun K. Ghosh

Department of Chemistry

Purdue University

West Lafayette

IN 47907

United States

[email]@purdue.edu

Name/email consistency: high

 
 
 
 
 
 
 

Affiliations

  • Department of Chemistry, Purdue University, West Lafayette, IN 47907, United States. 2005 - 2012
  • Department of Chemistry and Department of Medicinal Chemistry, Purdue University, West Lafayette, IN 47907 (USA) http://www.chem.purdue.edu/ghosh/. 2012

References

  1. Structure-based design, synthesis, and biological evaluation of dihydroquinazoline-derived potent β-secretase inhibitors. Ghosh, A.K., Pandey, S., Gangarajula, S., Kulkarni, S., Xu, X., Rao, K.V., Huang, X., Tang, J. Bioorg. Med. Chem. Lett. (2012) [Pubmed]
  2. Enhancing Protein Backbone Binding-A Fruitful Concept for Combating Drug-Resistant HIV. Ghosh, A.K., Anderson, D.D., Weber, I.T., Mitsuya, H. Angew. Chem. Int. Ed. Engl. (2012) [Pubmed]
  3. Design and synthesis of potent HIV-1 protease inhibitors incorporating hexahydrofuropyranol-derived high affinity P(2) ligands: structure-activity studies and biological evaluation. Ghosh, A.K., Chapsal, B.D., Baldridge, A., Steffey, M.P., Walters, D.E., Koh, Y., Amano, M., Mitsuya, H. J. Med. Chem. (2011) [Pubmed]
  4. Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction. Ghosh, A.K., Kass, J. Chem. Commun. (Camb.) (2010) [Pubmed]
  5. Enantioselective syntheses of the proposed structures of cytotoxic macrolides iriomoteolide-1a and -1b. Ghosh, A.K., Yuan, H. Org. Lett. (2010) [Pubmed]
  6. Synthesis and biological evaluation of novel allophenylnorstatine-based HIV-1 protease inhibitors incorporating high affinity P2-ligands. Ghosh, A.K., Gemma, S., Simoni, E., Baldridge, A., Walters, D.E., Ide, K., Tojo, Y., Koh, Y., Amano, M., Mitsuya, H. Bioorg. Med. Chem. Lett. (2010) [Pubmed]
  7. Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation. Ghosh, A.K., Takayama, J., Rao, K.V., Ratia, K., Chaudhuri, R., Mulhearn, D.C., Lee, H., Nichols, D.B., Baliji, S., Baker, S.C., Johnson, M.E., Mesecar, A.D. J. Med. Chem. (2010) [Pubmed]
  8. Synthesis and biological evaluation of new jasplakinolide (jaspamide) analogs. Ghosh, A.K., Dawson, Z.L., Moon, D.K., Bai, R., Hamel, E. Bioorg. Med. Chem. Lett. (2010) [Pubmed]
  9. Design, synthesis, protein-ligand X-ray structure, and biological evaluation of a series of novel macrocyclic human immunodeficiency virus-1 protease inhibitors to combat drug resistance. Ghosh, A.K., Kulkarni, S., Anderson, D.D., Hong, L., Baldridge, A., Wang, Y.F., Chumanevich, A.A., Kovalevsky, A.Y., Tojo, Y., Amano, M., Koh, Y., Tang, J., Weber, I.T., Mitsuya, H. J. Med. Chem. (2009) [Pubmed]
  10. An asymmetric total synthesis of brevisamide. Ghosh, A.K., Li, J. Org. Lett. (2009) [Pubmed]
  11. Structure-based design, synthesis, and biological evaluation of a series of novel and reversible inhibitors for the severe acute respiratory syndrome-coronavirus papain-like protease. Ghosh, A.K., Takayama, J., Aubin, Y., Ratia, K., Chaudhuri, R., Baez, Y., Sleeman, K., Coughlin, M., Nichols, D.B., Mulhearn, D.C., Prabhakar, B.S., Baker, S.C., Johnson, M.E., Mesecar, A.D. J. Med. Chem. (2009) [Pubmed]
  12. Total synthesis of (-)-platensimycin, a novel antibacterial agent. Ghosh, A.K., Xi, K. J. Org. Chem. (2009) [Pubmed]
  13. A symmetry-based concise formal synthesis of platencin, a novel lead against "superbugs". Ghosh, A.K., Xi, K. Angew. Chem. Int. Ed. Engl. (2009) [Pubmed]
  14. A convergent synthesis of the proposed structure of antitumor depsipeptide stereocalpin A. Ghosh, A.K., Xu, C.X. Org. Lett. (2009) [Pubmed]
  15. Asymmetric synthesis of anti-aldol segments via a nonaldol route: synthetic applications to statines and (-)-tetrahydrolipstatin. Ghosh, A.K., Shurrush, K., Kulkarni, S. J. Org. Chem. (2009) [Pubmed]
  16. Design of HIV-1 protease inhibitors with pyrrolidinones and oxazolidinones as novel P1'-ligands to enhance backbone-binding interactions with protease: synthesis, biological evaluation, and protein-ligand X-ray studies. Ghosh, A.K., Leshchenko-Yashchuk, S., Anderson, D.D., Baldridge, A., Noetzel, M., Miller, H.B., Tie, Y., Wang, Y.F., Koh, Y., Weber, I.T., Mitsuya, H. J. Med. Chem. (2009) [Pubmed]
  17. Harnessing nature's insight: design of aspartyl protease inhibitors from treatment of drug-resistant HIV to Alzheimer's disease. Ghosh, A.K. J. Med. Chem. (2009) [Pubmed]
  18. L-selectride-mediated highly diastereoselective asymmetric reductive aldol reaction: access to an important subunit for bioactive molecules. Ghosh, A.K., Kass, J., Anderson, D.D., Xu, X., Marian, C. Org. Lett. (2008) [Pubmed]
  19. Potent HIV-1 protease inhibitors incorporating meso-bicyclic urethanes as P2-ligands: structure-based design, synthesis, biological evaluation and protein-ligand X-ray studies. Ghosh, A.K., Gemma, S., Takayama, J., Baldridge, A., Leshchenko-Yashchuk, S., Miller, H.B., Wang, Y.F., Kovalevsky, A.Y., Koh, Y., Weber, I.T., Mitsuya, H. Org. Biomol. Chem. (2008) [Pubmed]
  20. Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies. Ghosh, A.K., Gemma, S., Baldridge, A., Wang, Y.F., Kovalevsky, A.Y., Koh, Y., Weber, I.T., Mitsuya, H. J. Med. Chem. (2008) [Pubmed]
  21. Potent memapsin 2 (beta-secretase) inhibitors: design, synthesis, protein-ligand X-ray structure, and in vivo evaluation. Ghosh, A.K., Kumaragurubaran, N., Hong, L., Kulkarni, S., Xu, X., Miller, H.B., Reddy, D.S., Weerasena, V., Turner, R., Chang, W., Koelsch, G., Tang, J. Bioorg. Med. Chem. Lett. (2008) [Pubmed]
  22. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Ghosh, A.K., Gong, G., Grum-Tokars, V., Mulhearn, D.C., Baker, S.C., Coughlin, M., Prabhakar, B.S., Sleeman, K., Johnson, M.E., Mesecar, A.D. Bioorg. Med. Chem. Lett. (2008) [Pubmed]
  23. Enantioselective total synthesis of peloruside A: a potent microtubule stabilizer. Ghosh, A.K., Xu, X., Kim, J.H., Xu, C.X. Org. Lett. (2008) [Pubmed]
  24. Enantioselective total synthesis of (+)-largazole, a potent inhibitor of histone deacetylase. Ghosh, A.K., Kulkarni, S. Org. Lett. (2008) [Pubmed]
  25. Design and synthesis of stereochemically defined novel spirocyclic P2-ligands for HIV-1 protease inhibitors. Ghosh, A.K., Chapsal, B.D., Baldridge, A., Ide, K., Koh, Y., Mitsuya, H. Org. Lett. (2008) [Pubmed]
  26. Design of HIV protease inhibitors targeting protein backbone: an effective strategy for combating drug resistance. Ghosh, A.K., Chapsal, B.D., Weber, I.T., Mitsuya, H. Acc. Chem. Res. (2008) [Pubmed]
  27. Memapsin 2 (beta-secretase) inhibitors: drug development. Ghosh, A.K., Kumaragurubaran, N., Hong, L., Koelsh, G., Tang, J. Current. Alzheimer. Research (2008) [Pubmed]
  28. Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors. Ghosh, A.K., Xi, K., Grum-Tokars, V., Xu, X., Ratia, K., Fu, W., Houser, K.V., Baker, S.C., Johnson, M.E., Mesecar, A.D. Bioorg. Med. Chem. Lett. (2007) [Pubmed]
  29. Enantioselective synthesis of (-)-platensimycin oxatetracyclic core by using an intramolecular Diels-Alder reaction. Ghosh, A.K., Xi, K. Org. Lett. (2007) [Pubmed]
  30. Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands. Ghosh, A.K., Kumaragurubaran, N., Hong, L., Kulkarni, S.S., Xu, X., Chang, W., Weerasena, V., Turner, R., Koelsch, G., Bilcer, G., Tang, J. J. Med. Chem. (2007) [Pubmed]
  31. Enantioselective total synthesis of macrolide antitumor agent (-)-lasonolide A. Ghosh, A.K., Gong, G. Org. Lett. (2007) [Pubmed]
  32. Enantioselective total synthesis of +-jasplakinolide. Ghosh, A.K., Moon, D.K. Org. Lett. (2007) [Pubmed]
  33. Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality. Ghosh, A.K., Bilcer, G., Hong, L., Koelsch, G., Tang, J. Current. Alzheimer. Research (2007) [Pubmed]
  34. Bis-tetrahydrofuran: a privileged ligand for darunavir and a new generation of hiv protease inhibitors that combat drug resistance. Ghosh, A.K., Ramu Sridhar, P., Kumaragurubaran, N., Koh, Y., Weber, I.T., Mitsuya, H. ChemMedChem (2006) [Pubmed]
  35. Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors. Ghosh, A.K., Kumaragurubaran, N., Hong, L., Lei, H., Hussain, K.A., Liu, C.F., Devasamudram, T., Weerasena, V., Turner, R., Koelsch, G., Bilcer, G., Tang, J. J. Am. Chem. Soc. (2006) [Pubmed]
  36. Total synthesis and revision of C6 stereochemistry of (+)-amphidinolide W. Ghosh, A.K., Gong, G. J. Org. Chem. (2006) [Pubmed]
  37. Design and synthesis of novel HIV-1 protease inhibitors incorporating oxyindoles as the P2'-ligands. Ghosh, A.K., Schiltz, G., Perali, R.S., Leshchenko, S., Kay, S., Walters, D.E., Koh, Y., Maeda, K., Mitsuya, H. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  38. Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance. Ghosh, A.K., Sridhar, P.R., Leshchenko, S., Hussain, A.K., Li, J., Kovalevsky, A.Y., Walters, D.E., Wedekind, J.E., Grum-Tokars, V., Das, D., Koh, Y., Maeda, K., Gatanaga, H., Weber, I.T., Mitsuya, H. J. Med. Chem. (2006) [Pubmed]
  39. Asymmetric multicomponent reactions: diastereoselective synthesis of substituted pyrrolidines and prolines. Ghosh, A.K., Kulkarni, S., Xu, C.X., Fanwick, P.E. Org. Lett. (2006) [Pubmed]
  40. Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors. Ghosh, A.K., Xi, K., Ratia, K., Santarsiero, B.D., Fu, W., Harcourt, B.H., Rota, P.A., Baker, S.C., Johnson, M.E., Mesecar, A.D. J. Med. Chem. (2005) [Pubmed]
  41. Recent developments of structure based beta-secretase inhibitors for Alzheimer's disease. Ghosh, A.K., Kumaragurubaran, N., Tang, J. Curr. Top. Med. Chem (2005) [Pubmed]
 
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