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Hiromi Kazuno

Hanno Research Center

Taiho Pharmaceutical Co.

Ltd., Hanno-city

Saitama 357-8527

Japan

[email]@taiho.co.jp

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Affiliation

Hanno Research Center, Taiho Pharmaceutical Co., Ltd., Hanno-city, Saitama 357-8527, Japan. 2005 - 2009

References

1-(3-C-Ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106), a novel potent inhibitor of RNA polymerase, potentiates the cytotoxicity of CDDP in human cancer cells both in vitro and in vivo. Kazuno, H., Fujioka, A., Fukushima, M., Wataya, Y., Matsuda, A., Sasaki, T. Int. J. Oncol. (2009) [Pubmed]
Mechanism of action of a new antitumor ribonucleoside, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106), differs from that of 5-fluorouracil. Kazuno, H., Shimamoto, Y., Tsujimoto, H., Fukushima, M., Matsuda, A., Sasaki, T. Oncol. Rep. (2007) [Pubmed]
Possible antitumor activity of 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine (ECyd, TAS-106) against an established gemcitabine (dFdCyd)-resistant human pancreatic cancer cell line. Kazuno, H., Sakamoto, K., Fujioka, A., Fukushima, M., Matsuda, A., Sasaki, T. Cancer Sci. (2005) [Pubmed]