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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Haruhiro Higashida

Department of Biophysical Genetics

Kanazawa University Graduate School of Medicine

Kanazawa 920-8640

Japan. Electronic address:


Name/email consistency: high



  • Department of Biophysical Genetics, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan. Electronic address:. 1997 - 2012


  1. A personal view from a long-lasting collaborator on the research strategies of Marshall Nirenberg. Higashida, H. Neurochem. Int. (2012) [Pubmed]
  2. Social memory, amnesia, and autism: Brain oxytocin secretion is regulated by NAD(+) metabolites and single nucleotide polymorphisms of CD38. Higashida, H., Yokoyama, S., Huang, J.J., Liu, L., Ma, W.J., Akther, S., Higashida, C., Kikuchi, M., Minabe, Y., Munesue, T. Neurochem. Int. (2012) [Pubmed]
  3. Oxytocin signal and social behaviour: comparison among adult and infant oxytocin, oxytocin receptor and CD38 gene knockout mice. Higashida, H., Lopatina, O., Yoshihara, T., Pichugina, Y.A., Soumarokov, A.A., Munesue, T., Minabe, Y., Kikuchi, M., Ono, Y., Korshunova, N., Salmina, A.B. J. Neuroendocrinol. (2010) [Pubmed]
  4. Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system. Higashida, H., Salmina, A.B., Olovyannikova, R.Y., Hashii, M., Yokoyama, S., Koizumi, K., Jin, D., Liu, H.X., Lopatina, O., Amina, S., Islam, M.S., Huang, J.J., Noda, M. Neurochem. Int. (2007) [Pubmed]
  5. Overexpression of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced Ca2+ signalling in rodent NG108-15 neuroblastoma cells. Higashida, H., Bowden, S.E., Yokoyama, S., Salmina, A., Hashii, M., Hoshi, N., Zhang, J.S., Knijnik, R., Noda, M., Zhong, Z.G., Jin, D., Higashida, K., Takeda, H., Akita, T., Kuba, K., Yamagishi, S., Shimizu, N., Takasawa, S., Okamoto, H., Robbins, J. Neurosci. Res. (2007) [Pubmed]
  6. Bradykinin activates ADP-ribosyl cyclase in neuroblastoma cells: intracellular concentration decrease in NAD and increase in cyclic ADP-ribose. Higashida, H., Salmina, A., Hashii, M., Yokoyama, S., Zhang, J.S., Noda, M., Zhong, Z.G., Jin, D. FEBS Lett. (2006) [Pubmed]
  7. Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels. Higashida, H., Hoshi, N., Zhang, J.S., Yokoyama, S., Hashii, M., Jin, D., Noda, M., Robbins, J. Neurosci. Res. (2005) [Pubmed]
  8. Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical superior ganglion and NG108-15 cells. Higashida, H., Zhang, J.S., Mochida, S., Chen, X.L., Shin, Y., Noda, M., Hossain, K.Z., Hoshi, N., Hashii, M., Shigemoto, R., Nakanishi, S., Fukuda, Y., Yokoyama, S. J. Neurochem. (2003) [Pubmed]
  9. Measurement of adenylyl cyclase by separating cyclic AMP on silica gel thin-layer chromatography. Higashida, H., Hossain, K.Z., Takahagi, H., Noda, M. Anal. Biochem. (2002) [Pubmed]
  10. Cyclic ADP-ribose as a potential second messenger for neuronal Ca2+ signaling. Higashida, H., Hashii, M., Yokoyama, S., Hoshi, N., Asai, K., Kato, T. J. Neurochem. (2001) [Pubmed]
  11. Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase. Higashida, H., Hashii, M., Yokoyama, S., Hoshi, N., Chen, X.L., Egorova, A., Noda, M., Zhang, J.S. Pharmacol. Ther. (2001) [Pubmed]
  12. Angiotensin II stimulates cyclic ADP-ribose formation in neonatal rat cardiac myocytes. Higashida, H., Zhang, J., Hashii, M., Shintaku, M., Higashida, C., Takeda, Y. Biochem. J. (2000) [Pubmed]
  13. Sympathetic potentiation of cyclic ADP-ribose formation in rat cardiac myocytes. Higashida, H., Egorova, A., Higashida, C., Zhong, Z.G., Yokoyama, S., Noda, M., Zhang, J.S. J. Biol. Chem. (1999) [Pubmed]
  14. Potential mechanism for bradykinin-activated and inositol tetrakisphosphate-dependent Ca2+ influx by Ras and GAP1 in fibroblast cells. Higashida, H., Taketo, M., Takahashi, H., Yokoyama, S., Hashii, M. Immunopharmacology (1999) [Pubmed]
  15. Endomorphins inhibit high-threshold Ca2+ channel currents in rodent NG108-15 cells overexpressing mu-opioid receptors. Higashida, H., Hoshi, N., Knijnik, R., Zadina, J.E., Kastin, A.J. J. Physiol. (Lond.) (1998) [Pubmed]
  16. Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes. Higashida, H., Yokoyama, S., Hashii, M., Taketo, M., Higashida, M., Takayasu, T., Ohshima, T., Takasawa, S., Okamoto, H., Noda, M. J. Biol. Chem. (1997) [Pubmed]
  17. ADP-ribosyl cyclase coupled with receptors via G proteins. Higashida, H. FEBS Lett. (1997) [Pubmed]
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