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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Jan Balzarini

Rega Institute for Medical Research

Katholieke Universiteit Leuven

Belgium

[email]@*.kuleuven.ac.be

Name/email consistency: high

 
 
 
 
 
 
 

Affiliations

  • Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium. 1996 - 2007
  • Rega Institute for Medical Research, Belgium. 2004
  • Laboratory of Virology & Chemotherapy, Rega Institute for Medical Research, B-3000 Leuven, Belgium. 2002

References

  1. Pradimicin A, a carbohydrate-binding nonpeptidic lead compound for treatment of infections with viruses with highly glycosylated envelopes, such as human immunodeficiency virus. Balzarini, J., Van Laethem, K., Daelemans, D., Hatse, S., Bugatti, A., Rusnati, M., Igarashi, Y., Oki, T., Schols, D. J. Virol. (2007) [Pubmed]
  2. Pyridine N-oxide derivatives are inhibitory to the human SARS and feline infectious peritonitis coronavirus in cell culture. Balzarini, J., Keyaerts, E., Vijgen, L., Vandermeer, F., Stevens, M., De Clercq, E., Egberink, H., Van Ranst, M. J. Antimicrob. Chemother. (2006) [Pubmed]
  3. Pyridine N-oxide derivatives: unusual anti-HIV compounds with multiple mechanisms of antiviral action. Balzarini, J., Stevens, M., De Clercq, E., Schols, D., Pannecouque, C. J. Antimicrob. Chemother. (2005) [Pubmed]
  4. Marked depletion of glycosylation sites in HIV-1 gp120 under selection pressure by the mannose-specific plant lectins of Hippeastrum hybrid and Galanthus nivalis. Balzarini, J., Van Laethem, K., Hatse, S., Froeyen, M., Van Damme, E., Bolmstedt, A., Peumans, W., De Clercq, E., Schols, D. Mol. Pharmacol. (2005) [Pubmed]
  5. Current status of the non-nucleoside reverse transcriptase inhibitors of human immunodeficiency virus type 1. Balzarini, J. Curr. Top. Med. Chem (2004) [Pubmed]
  6. Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)). Balzarini, J., Andersson, E., Schols, D., Proost, P., Van Damme, J., Svennerholm, B., Horal, P., Vahlne, A. Int. J. Biochem. Cell Biol. (2004) [Pubmed]
  7. Profile of resistance of human immunodeficiency virus to mannose-specific plant lectins. Balzarini, J., Van Laethem, K., Hatse, S., Vermeire, K., De Clercq, E., Peumans, W., Van Damme, E., Vandamme, A.M., Bölmstedt, A., Schols, D., Böhlmstedt, A. J. Virol. (2004) [Pubmed]
  8. Mannose-specific plant lectins from the Amaryllidaceae family qualify as efficient microbicides for prevention of human immunodeficiency virus infection. Balzarini, J., Hatse, S., Vermeire, K., Princen, K., Aquaro, S., Perno, C.F., De Clercq, E., Egberink, H., Vanden Mooter, G., Peumans, W., Van Damme, E., Schols, D. Antimicrob. Agents Chemother. (2004) [Pubmed]
  9. Non-nucleoside inhibitors of mitochondrial thymidine kinase (TK-2) differentially inhibit the closely related herpes simplex virus type 1 TK and Drosophila melanogaster multifunctional deoxynucleoside kinase. Balzarini, J., Hernández, A.I., Roche, P., Esnouf, R., Karlsson, A., Camarasa, M.J., Pérez-Pérez, M.J. Mol. Pharmacol. (2003) [Pubmed]
  10. Lack of susceptibility of bicyclic nucleoside analogs, highly potent inhibitors of varicella-zoster virus, to the catabolic action of thymidine phosphorylase and dihydropyrimidine dehydrogenase. Balzarini, J., Sienaert, R., Liekens, S., Van Kuilenburg, A., Carangio, A., Esnouf, R., De Clercq, E., McGuigan, C. Mol. Pharmacol. (2002) [Pubmed]
  11. The A167Y mutation converts the herpes simplex virus type 1 thymidine kinase into a guanosine analogue kinase. Balzarini, J., Liekens, S., Esnouf, R., De Clercq, E. Biochemistry (2002) [Pubmed]
  12. Antiretrovirus activity of a novel class of acyclic pyrimidine nucleoside phosphonates. Balzarini, J., Pannecouque, C., De Clercq, E., Aquaro, S., Perno, C.F., Egberink, H., Holý, A. Antimicrob. Agents Chemother. (2002) [Pubmed]
  13. Chemotherapy of varicella-zoster virus by a novel class of highly specific anti-VZV bicyclic pyrimidine nucleosides. Balzarini, J., McGuigan, C. Biochim. Biophys. Acta (2002) [Pubmed]
  14. Bicyclic pyrimidine nucleoside analogues (BCNAs) as highly selective and potent inhibitors of varicella-zoster virus replication. Balzarini, J., McGuigan, C. J. Antimicrob. Chemother. (2002) [Pubmed]
  15. Metabolic activation of nucleoside and nucleotide reverse transcriptase inhibitors in dendritic and Langerhans cells. Balzarini, J., Van Herrewege, Y., Vanham, G. AIDS (2002) [Pubmed]
  16. 2'-O-Acyl/alkyl-substituted arabinosyl nucleosides as inhibitors of human mitochondrial thymidine kinase. Balzarinia, J., Degrève, B., Zhu, C., Durini, E., Porcu, L., De Clercq, E., Karlsson, A., Manfredini, S. Biochem. Pharmacol. (2001) [Pubmed]
  17. Exploitation of the low fidelity of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and the nucleotide composition bias in the HIV-1 genome to alter the drug resistance development of HIV. Balzarini, J., Camarasa, M.J., Pérez-Pérez, M.J., San-Félix, A., Velázquez, S., Perno, C.F., De Clercq, E., Anderson, J.N., Karlsson, A. J. Virol. (2001) [Pubmed]
  18. Rapid alternation of drug therapy is highly efficient in suppressing the emergence of mutant drug-resistant HIV strains in cell culture. Balzarini, J., De Clercq, E. AIDS Res. Hum. Retroviruses (2001) [Pubmed]
  19. Antiviral activity of cyclosaligenyl prodrugs of acyclovir, carbovir and abacavir. Balzarini, J., Haller-Meier, F., De Clercq, E., Meier, C. Antivir. Chem. Chemother. (2001) [Pubmed]
  20. Novel ribofuranosylnucleoside lead compounds for potent and selective inhibitors of mitochondrial thymidine kinase-2. Balzarini, J., Zhu, C., De Clercq, E., Pérez-Pérez, M.J., Chamorro, C., Camarasa, M.J., Karlsson, A. Biochem. J. (2000) [Pubmed]
  21. Cyclosaligenyl-2',3'-didehydro-2',3'-dideoxythymidine monophosphate: efficient intracellular delivery of d4TMP. Balzarini, J., Aquaro, S., Knispel, T., Rampazzo, C., Bianchi, V., Perno, C.F., De Clercq, E., Meier, C. Mol. Pharmacol. (2000) [Pubmed]
  22. Kinetic analysis of novel multisubstrate analogue inhibitors of thymidine phosphorylase. Balzarini, J., Degrève, B., Esteban-Gamboa, A., Esnouf, R., De Clercq, E., Engelborghs, Y., Camarasa, M.J., Pérez-Pérez, M.J. FEBS Lett. (2000) [Pubmed]
  23. Suppression of resistance to drugs targeted to human immunodeficiency virus reverse transcriptase by combination therapy. Balzarini, J. Biochem. Pharmacol. (1999) [Pubmed]
  24. Intracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine). Balzarini, J., Naesens, L., Aquaro, S., Knispel, T., Perno, C., De Clercq, E., Meier, C. Mol. Pharmacol. (1999) [Pubmed]
  25. A novel mutation (F227L) arises in the reverse transcriptase of human immunodeficiency virus type 1 on dose-escalating treatment of HIV type 1-infected cell cultures with the nonnucleoside reverse transcriptase inhibitor thiocarboxanilide UC-781. Balzarini, J., Pelemans, H., Esnouf, R., De Clercq, E. AIDS Res. Hum. Retroviruses (1998) [Pubmed]
  26. Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA). Balzarini, J., Hatse, S., Naesens, L., De Clercq, E. Biochim. Biophys. Acta (1998) [Pubmed]
  27. Highly favorable antiviral activity and resistance profile of the novel thiocarboxanilide pentenyloxy ether derivatives UC-781 and UC-82 as inhibitors of human immunodeficiency virus type 1 replication. Balzarini, J., Pelemans, H., Aquaro, S., Perno, C.F., Witvrouw, M., Schols, D., De Clercq, E., Karlsson, A. Mol. Pharmacol. (1996) [Pubmed]
  28. Antiretrovirus specificity and intracellular metabolism of 2',3' -didehydro-2',3'-dideoxythymidine (stavudine) and its 5'-monophosphate triester prodrug So324. Balzarini, J., Egberink, H., Hartmann, K., Cahard, D., Vahlenkamp, T., Thormar, H., De Clercq, E., McGuigan, C. Mol. Pharmacol. (1996) [Pubmed]
 
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