Jan Balzarini
Rega Institute for Medical Research
Katholieke Universiteit Leuven
B-3000 Leuven
Belgium
Name/email consistency: high
- Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway. Balzarini, J., Gago, F., Kulik, W., van Kuilenburg, A.B., Karlsson, A., Peterson, M.A., Robins, M.J. J. Biol. Chem. (2012)
- Combination of antiretroviral drugs as microbicides. Balzarini, J., Schols, D. Curr. HIV Res. (2012)
- Pradimicin S, a highly soluble nonpeptidic small-size carbohydrate-binding antibiotic, is an anti-HIV drug lead for both microbicidal and systemic use. Balzarini, J., François, K.O., Van Laethem, K., Hoorelbeke, B., Renders, M., Auwerx, J., Liekens, S., Oki, T., Igarashi, Y., Schols, D. Antimicrob. Agents Chemother. (2010)
- Human mitochondrial thymidine kinase is selectively inhibited by 3'-thiourea derivatives of beta-thymidine: identification of residues crucial for both inhibition and catalytic activity. Balzarini, J., Van Daele, I., Negri, A., Solaroli, N., Karlsson, A., Liekens, S., Gago, F., Van Calenbergh, S. Mol. Pharmacol. (2009)
- Carbohydrate-binding agents: a potential future cornerstone for the chemotherapy of enveloped viruses? Balzarini, J. Antivir. Chem. Chemother. (2007)
- The alpha(1,2)-mannosidase I inhibitor 1-deoxymannojirimycin potentiates the antiviral activity of carbohydrate-binding agents against wild-type and mutant HIV-1 strains containing glycan deletions in gp120. Balzarini, J. FEBS Lett. (2007)
- Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes. Balzarini, J., Van Herrewege, Y., Vermeire, K., Vanham, G., Schols, D. Mol. Pharmacol. (2007)
- Pronounced in vitro and in vivo antiretroviral activity of 5-substituted 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy] pyrimidines. Balzarini, J., Schols, D., Van Laethem, K., De Clercq, E., Hocková, D., Masojidkova, M., Holý, A. J. Antimicrob. Chemother. (2007)
- Microbicide drug candidates to prevent HIV infection. Balzarini, J., Van Damme, L. Lancet (2007)
- Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy. Balzarini, J. Nat. Rev. Microbiol. (2007)
- The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3'-fluoro-3'-deoxythymidine and 1-beta-D-arabinosylthymine on their antiviral and cytostatic activity in cell culture. Balzarini, J., Celen, S., Karlsson, A., de Groot, T., Verbruggen, A., Bormans, G. Antivir. Chem. Chemother. (2006)
- Inhibition of HIV entry by carbohydrate-binding proteins. Balzarini, J. Antiviral Res. (2006)
- Inhibition of feline (FIPV) and human (SARS) coronavirus by semisynthetic derivatives of glycopeptide antibiotics. Balzarini, J., Keyaerts, E., Vijgen, L., Egberink, H., De Clercq, E., Van Ranst, M., Printsevskaya, S.S., Olsufyeva, E.N., Solovieva, S.E., Preobrazhenskaya, M.N. Antiviral Res. (2006)
- Engineering of a single conserved amino acid residue of herpes simplex virus type 1 thymidine kinase allows a predominant shift from pyrimidine to purine nucleoside phosphorylation. Balzarini, J., Liekens, S., Solaroli, N., El Omari, K., Stammers, D.K., Karlsson, A. J. Biol. Chem. (2006)
- Mutational pathways, resistance profile, and side effects of cyanovirin relative to human immunodeficiency virus type 1 strains with N-glycan deletions in their gp120 envelopes. Balzarini, J., Van Laethem, K., Peumans, W.J., Van Damme, E.J., Bolmstedt, A., Gago, F., Schols, D. J. Virol. (2006)
- Large-molecular-weight carbohydrate-binding agents as HIV entry inhibitors targeting glycoprotein gp120. Balzarini, J. Curr. Opin. HIV. AIDS (2006)
- The amino acid Asn136 in HIV-1 reverse transcriptase (RT) maintains efficient association of both RT subunits and enables the rational design of novel RT inhibitors. Balzarini, J., Auwerx, J., Rodríguez-Barrios, F., Chedad, A., Farkas, V., Ceccherini-Silberstein, F., García-Aparicio, C., Velázquez, S., De Clercq, E., Perno, C.F., Camarasa, M.J., Gago, F. Mol. Pharmacol. (2005)
- Carbohydrate-binding agents cause deletions of highly conserved glycosylation sites in HIV GP120: a new therapeutic concept to hit the achilles heel of HIV. Balzarini, J., Van Laethem, K., Hatse, S., Froeyen, M., Peumans, W., Van Damme, E., Schols, D. J. Biol. Chem. (2005)
- Targeting the glycans of gp120: a novel approach aimed at the Achilles heel of HIV. Balzarini, J. Lancet. Infect. Dis (2005)
