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Janet J. Maguire

Clinical Pharmacology Unit

University of Cambridge

Level 6 ACCI

Box 110 Addenbrooke's Hospital

UK. Electronic address:


Name/email consistency: high



  • Clinical Pharmacology Unit, University of Cambridge, Level 6 ACCI, Box 110 Addenbrooke's Hospital, UK. Electronic address:. 2012
  • Clinical Pharmacology Unit, Addenbrooke's Centre for Clinical Investigation, University of Cambridge, Cambridge, UK. 1999 - 2012


  1. Defining the affinity and receptor sub-type selectivity of four classes of endothelin antagonists in clinically relevant human cardiovascular tissues. Maguire, J.J., Kuc, R.E., Davenport, A.P. Life Sci. (2012) [Pubmed]
  2. Comparison of human ET(A) and ET(B) receptor signalling via G-protein and β-arrestin pathways. Maguire, J.J., Kuc, R.E., Pell, V.R., Green, A., Brown, M., Kumar, S., Wehrman, T., Quinn, E., Davenport, A.P. Life Sci. (2012) [Pubmed]
  3. Radioligand binding assays and their analysis. Maguire, J.J., Kuc, R.E., Davenport, A.P. Methods Mol. Biol. (2012) [Pubmed]
  4. [Pyr1]apelin-13 identified as the predominant apelin isoform in the human heart: vasoactive mechanisms and inotropic action in disease. Maguire, J.J., Kleinz, M.J., Pitkin, S.L., Davenport, A.P. Hypertension (2009) [Pubmed]
  5. Immunocytochemical localization of the urotensin-II receptor, UT, to rat and human tissues: relevance to function. Maguire, J.J., Kuc, R.E., Kleinz, M.J., Davenport, A.P. Peptides (2008) [Pubmed]
  6. Endothelin-mediated vasoconstriction in early atherosclerosis is markedly increased in ApoE-/- mouse but prevented by atorvastatin. Maguire, J.J., Wiley, K.E., Kuc, R.E., Stoneman, V.E., Bennett, M.R., Davenport, A.P. Exp. Biol. Med. (Maywood) (2006) [Pubmed]
  7. Cellular distribution of immunoreactive urotensin-II in human tissues with evidence of increased expression in atherosclerosis and a greater constrictor response of small compared to large coronary arteries. Maguire, J.J., Kuc, R.E., Wiley, K.E., Kleinz, M.J., Davenport, A.P. Peptides (2004) [Pubmed]
  8. Alternative pathway to endothelin-converting enzyme for the synthesis of endothelin in human blood vessels. Maguire, J., Davenport, A.P. J. Cardiovasc. Pharmacol. (2004) [Pubmed]
  9. Discovering orphan receptor function using human in vitro pharmacology. Maguire, J.J. Curr. Opin. Pharmacol (2003) [Pubmed]
  10. ETA receptor antagonists inhibit intimal smooth muscle cell proliferation in human vessels. Maguire, J.J., Yu, J.C., Davenport, A.P. Clin. Sci. (2002) [Pubmed]
  11. Is urotensin-II the new endothelin?. Maguire, J.J., Davenport, A.P. Br. J. Pharmacol. (2002) [Pubmed]
  12. Vasoconstrictor activity of novel endothelin peptide, ET-1(1 - 31), in human mammary and coronary arteries in vitro. Maguire, J.J., Kuc, R.E., Davenport, A.P. Br. J. Pharmacol. (2001) [Pubmed]
  13. No alteration in vasoconstrictor endothelin-B-receptor density or function in human coronary artery disease. Maguire, J.J., Davenport, A.P. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  14. Endothelin receptor expression and pharmacology in human saphenous vein graft. Maguire, J.J., Davenport, A.P. Br. J. Pharmacol. (1999) [Pubmed]
  15. The therapeutic potential of PD156707 and related butenolide endothelin antagonists. Maguire, J.J., Davenport, A.P. Expert. Opin. Investig. Drugs (1999) [Pubmed]
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