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Javier Abel Menendez

Evanston Northwestern Healthcare Research Institute

Evanston

IL 60201

USA

[email]@enh.org

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Affiliations

Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA. 2004 - 2006
Department of Medicine, Breast Cancer Translational Research Laboratory, Evanston Northwestern Healthcare Research Institute (ENHRI), Evanston, USA. 2005 - 2006

References

The antiobesity drug Orlistat induces cytotoxic effects, suppresses Her-2/neu (erbB-2) oncogene overexpression, and synergistically interacts with trastuzumab (Herceptin) in chemoresistant ovarian cancer cells. Menendez, J.A., Vellon, L., Lupu, R. Int. J. Gynecol. Cancer (2006) [Pubmed]
DNA topoisomerase IIalpha (TOP2A) inhibitors up-regulate fatty acid synthase gene expression in SK-Br3 breast cancer cells: in vitro evidence for a 'functional amplicon' involving FAS, Her-2/neu and TOP2A genes. Menendez, J.A., Vellon, L., Lupu, R. Int. J. Mol. Med. (2006) [Pubmed]
Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity. Menendez, J.A., Vellon, L., Colomer, R., Lupu, R. Int. J. Cancer (2005) [Pubmed]
Orlistat: from antiobesity drug to anticancer agent in Her-2/neu (erbB-2)-overexpressing gastrointestinal tumors?. Menendez, J.A., Vellon, L., Lupu, R. Exp. Biol. Med. (Maywood) (2005) [Pubmed]
Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene. Menendez, J.A., Vellon, L., Lupu, R. Ann. Oncol. (2005) [Pubmed]
Exogenous supplementation with omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA; 22:6n-3) synergistically enhances taxane cytotoxicity and downregulates Her-2/neu (c-erbB-2) oncogene expression in human breast cancer cells. Menendez, J.A., Lupu, R., Colomer, R. Eur. J. Cancer Prev. (2005) [Pubmed]
Targeting fatty acid synthase: potential for therapeutic intervention in her-2/neu-overexpressing breast cancer. Menendez, J.A., Lupu, R., Colomer, R. Drug News Perspect. (2005) [Pubmed]
Effect of gamma-linolenic acid on the transcriptional activity of the Her-2/neu (erbB-2) oncogene. Menendez, J.A., Vellon, L., Colomer, R., Lupu, R. J. Natl. Cancer Inst. (2005) [Pubmed]
Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) enhances docetaxel (Taxotere) cytotoxicity in human breast carcinoma cells: Relationship to lipid peroxidation and HER-2/neu expression. Menendez, J.A., Ropero, S., Lupu, R., Colomer, R. Oncol. Rep. (2004) [Pubmed]