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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

John H. Krystal

Clinical Neuroscience Division

Department of Veterans Affairs National Center for PTSD

VA Connecticut Healthcare System

West Haven



Name/email consistency: high



  • Clinical Neuroscience Division, Department of Veterans Affairs National Center for PTSD, VA Connecticut Healthcare System, West Haven, USA. 2004 - 2011
  • Department of Psychiatry, NIAAA Center for the Translational Neuroscience of Alcoholism, Yale University School of Medicine, New Haven, USA. 2003 - 2011
  • Department of Psychiatry, Yale University School of Medicine, Ste 901, 300 George St, USA. 1999 - 2010
  • Department of Psychiatry, Yale University School of Medicine, and Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, USA. 2008
  • Alcohol Research Center, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA. 2001 - 2008


  1. Adjunctive risperidone treatment for antidepressant-resistant symptoms of chronic military service-related PTSD: a randomized trial. Krystal, J.H., Rosenheck, R.A., Cramer, J.A., Vessicchio, J.C., Jones, K.M., Vertrees, J.E., Horney, R.A., Huang, G.D., Stock, C. JAMA (2011) [Pubmed]
  2. Characterization of the interactive effects of glycine and D-cycloserine in men: further evidence for enhanced NMDA receptor function associated with human alcohol dependence. Krystal, J.H., Petrakis, I.L., Limoncelli, D., Nappi, S.K., Trevisan, L., Pittman, B., D'Souza, D.C., Suckow, R.F. Neuropsychopharmacology (2011) [Pubmed]
  3. N-methyl-D-aspartate glutamate receptor antagonists and the promise of rapid-acting antidepressants. Krystal, J.H. Arch. Gen. Psychiatry (2010) [Pubmed]
  4. Potential psychiatric applications of metabotropic glutamate receptor agonists and antagonists. Krystal, J.H., Mathew, S.J., D'Souza, D.C., Garakani, A., Gunduz-Bruce, H., Charney, D.S. CNS. Drugs (2010) [Pubmed]
  5. Neuroplasticity as a target for the pharmacotherapy of anxiety disorders, mood disorders, and schizophrenia. Krystal, J.H., Tolin, D.F., Sanacora, G., Castner, S.A., Williams, G.V., Aikins, D.E., Hoffman, R.E., D'Souza, D.C. Drug Discov. Today (2009) [Pubmed]
  6. The evolution of the psychiatry research journal. Krystal, J.H. J. Clin. Psychiatry (2009) [Pubmed]
  7. Capitalizing on extrasynaptic glutamate neurotransmission to treat antipsychotic-resistant symptoms in schizophrenia. Krystal, J.H. Biol. Psychiatry (2008) [Pubmed]
  8. Naltrexone is associated with reduced drinking by alcohol dependent patients receiving antidepressants for mood and anxiety symptoms: results from VA Cooperative Study No. 425, "Naltrexone in the treatment of alcoholism". Krystal, J.H., Gueorguieva, R., Cramer, J., Collins, J., Rosenheck, R. Alcohol. Clin. Exp. Res. (2008) [Pubmed]
  9. It is time to take a stand for medical research and against terrorism targeting medical scientists. Krystal, J.H., Carter, C.S., Geschwind, D., Manji, H.K., March, J.S., Nestler, E.J., Zubieta, J.K., Charney, D.S., Goldman, D., Gur, R.E., Lieberman, J.A., Roy-Byrne, P., Rubinow, D.R., Anderson, S.A., Barondes, S., Berman, K.F., Blair, J., Braff, D.L., Brown, E.S., Calabrese, J.R., Carlezon, W.A., Cook, E.H., Davidson, R.J., Davis, M., Desimone, R., Drevets, W.C., Duman, R.S., Essock, S.M., Faraone, S.V., Freedman, R., Friston, K.J., Gelernter, J., Geller, B., Gill, M., Gould, E., Grace, A.A., Grillon, C., Gueorguieva, R., Hariri, A.R., Innis, R.B., Jones, E.G., Kleinman, J.E., Koob, G.F., Krystal, A.D., Leibenluft, E., Levinson, D.F., Levitt, P.R., Lewis, D.A., Liberzon, I., Lipska, B.K., Marder, S.R., Markou, A., Mason, G.F., McDougle, C.J., McEwen, B.S., McMahon, F.J., Meaney, M.J., Meltzer, H.Y., Merikangas, K.R., Meyer-Lindenberg, A., Mirnics, K., Monteggia, L.M., Neumeister, A., O'Brien, C.P., Owen, M.J., Pine, D.S., Rapoport, J.L., Rauch, S.L., Robbins, T.W., Rosenbaum, J.F., Rosenberg, D.R., Ross, C.A., Rush, A.J., Sackeim, H.A., Sanacora, G., Schatzberg, A.F., Shaham, Y., Siever, L.J., Sunderland, T., Tecott, L.H., Thase, M.E., Todd, R.D., Weissman, M.M., Yehuda, R., Yoshikawa, T., Young, E.A., McCandless, R. Biol. Psychiatry (2008) [Pubmed]
  10. Neuroplasticity as a target for the pharmacotherapy of psychiatric disorders: new opportunities for synergy with psychotherapy. Krystal, J.H. Biol. Psychiatry (2007) [Pubmed]
  11. Potentiation of low dose ketamine effects by naltrexone: potential implications for the pharmacotherapy of alcoholism. Krystal, J.H., Madonick, S., Perry, E., Gueorguieva, R., Brush, L., Wray, Y., Belger, A., D'Souza, D.C. Neuropsychopharmacology (2006) [Pubmed]
  12. Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment. Krystal, J.H., Staley, J., Mason, G., Petrakis, I.L., Kaufman, J., Harris, R.A., Gelernter, J., Lappalainen, J. Arch. Gen. Psychiatry (2006) [Pubmed]
  13. The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia. Krystal, J.H., D'Souza, D.C., Gallinat, J., Driesen, N., Abi-Dargham, A., Petrakis, I., Heinz, A., Pearlson, G. Neurotox. Res (2006) [Pubmed]
  14. Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. Krystal, J.H., Abi-Saab, W., Perry, E., D'Souza, D.C., Liu, N., Gueorguieva, R., McDougall, L., Hunsberger, T., Belger, A., Levine, L., Breier, A. Psychopharmacology (Berl.) (2005) [Pubmed]
  15. Comparative and interactive human psychopharmacologic effects of ketamine and amphetamine: implications for glutamatergic and dopaminergic model psychoses and cognitive function. Krystal, J.H., Perry, E.B., Gueorguieva, R., Belger, A., Madonick, S.H., Abi-Dargham, A., Cooper, T.B., Macdougall, L., Abi-Saab, W., D'Souza, D.C. Arch. Gen. Psychiatry (2005) [Pubmed]
  16. What's missing in posttraumatic stress disorder research? Studies of human postmortem tissue. Krystal, J.H., Duman, R. Psychiatry (2004) [Pubmed]
  17. N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability. Krystal, J.H., Petrakis, I.L., Mason, G., Trevisan, L., D'Souza, D.C. Pharmacol. Ther. (2003) [Pubmed]
  18. Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients. Krystal, J.H., Petrakis, I.L., Limoncelli, D., Webb, E., Gueorgueva, R., D'Souza, D.C., Boutros, N.N., Trevisan, L., Charney, D.S. Neuropsychopharmacology (2003) [Pubmed]
  19. NMDA receptor antagonist effects, cortical glutamatergic function, and schizophrenia: toward a paradigm shift in medication development. Krystal, J.H., D'Souza, D.C., Mathalon, D., Perry, E., Belger, A., Hoffman, R. Psychopharmacology (Berl.) (2003) [Pubmed]
  20. NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy. Krystal, J.H., Petrakis, I.L., Krupitsky, E., Schutz, C., Trevisan, L., D'Souza, D.C. Ann. N. Y. Acad. Sci. (2003) [Pubmed]
  21. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Krystal, J.H., Sanacora, G., Blumberg, H., Anand, A., Charney, D.S., Marek, G., Epperson, C.N., Goddard, A., Mason, G.F. Mol. Psychiatry (2002) [Pubmed]
  22. Commentary: first, do no harm. Then, do some good: ethics and human experimental psychopharmacology. Krystal, J.H. Isr. J. Psychiatry. Relat. Sci (2002) [Pubmed]
  23. Current perspectives on the pathophysiology of schizophrenia, depression, and anxiety disorders. Krystal, J.H., D'Souza, D.C., Sanacora, G., Goddard, A.W., Charney, D.S. Med. Clin. North Am. (2001) [Pubmed]
  24. Naltrexone in the treatment of alcohol dependence. Krystal, J.H., Cramer, J.A., Krol, W.F., Kirk, G.F., Rosenheck, R.A. N. Engl. J. Med. (2001) [Pubmed]
  25. Toward a rational pharmacotherapy of comorbid substance abuse in schizophrenic patients. Krystal, J.H., D'Souza, D.C., Madonick, S., Petrakis, I.L. Schizophr. Res. (1999) [Pubmed]
  26. Interactive effects of subanesthetic ketamine and haloperidol in healthy humans. Krystal, J.H., D'Souza, D.C., Karper, L.P., Bennett, A., Abi-Dargham, A., Abi-Saab, D., Cassello, K., Bowers, M.B., Vegso, S., Heninger, G.R., Charney, D.S. Psychopharmacology (Berl.) (1999) [Pubmed]
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