Jürgen Pauluhn
Department of Inhalation Toxicology
Institute of Toxicology
Bayer Schering Pharmaceuticals
Building no. 514
Germany
Name/email consistency: high
- Poorly soluble particulates: searching for a unifying denominator of nanoparticles and fine particles for DNEL estimation. Pauluhn, J. Toxicology (2011)
- Subchronic 13-week inhalation exposure of rats to multiwalled carbon nanotubes: toxic effects are determined by density of agglomerate structures, not fibrillar structures. Pauluhn, J. Toxicol. Sci. (2010)
- Multi-walled carbon nanotubes (Baytubes): approach for derivation of occupational exposure limit. Pauluhn, J. Regul. Toxicol. Pharmacol. (2010)
- Pulmonary toxicity and fate of agglomerated 10 and 40 nm aluminum oxyhydroxides following 4-week inhalation exposure of rats: toxic effects are determined by agglomerated, not primary particle size. Pauluhn, J. Toxicol. Sci. (2009)
- Retrospective analysis of 4-week inhalation studies in rats with focus on fate and pulmonary toxicity of two nanosized aluminum oxyhydroxides (boehmite) and pigment-grade iron oxide (magnetite): the key metric of dose is particle mass and not particle surface area. Pauluhn, J. Toxicology (2009)
- Comparative pulmonary response to inhaled nanostructures: considerations on test design and endpoints. Pauluhn, J. Inhal. Toxicol (2009)
- Assessment of early acute lung injury in rats exposed to aerosols of consumer products: attempt to disentangle the "Magic Nano" conundrum. Pauluhn, J., Hahn, A., Spielmann, H. Inhal. Toxicol (2008)
- Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): impact of vehicle for topical induction. Pauluhn, J. Regul. Toxicol. Pharmacol. (2008)
- Comparative assessment of early acute lung injury in mice and rats exposed to 1,6-hexamethylene diisocyanate-polyisocyanate aerosols. Pauluhn, J. Toxicology (2008)
- Inhalation toxicology: methodological and regulatory challenges. Pauluhn, J. Exp. Toxicol. Pathol. (2008)
- Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): analysis of the elicitation dose-response relationship. Pauluhn, J. Toxicol. Sci. (2008)
- A simple approach to validation of directed-flow nose-only inhalation chambers. Pauluhn, J., Thiel, A. J. Appl. Toxicol (2007)
- Workshop summary: phosgene-induced pulmonary toxicity revisited: appraisal of early and late markers of pulmonary injury from animal models with emphasis on human significance. Pauluhn, J., Carson, A., Costa, D.L., Gordon, T., Kodavanti, U., Last, J.A., Matthay, M.A., Pinkerton, K.E., Sciuto, A.M. Inhal. Toxicol (2007)
- Mosquito coil smoke inhalation toxicity. Part I: validation of test approach and acute inhalation toxicity. Pauluhn, J. J. Appl. Toxicol (2006)
- Mosquito coil smoke inhalation toxicity. Part II: subchronic nose-only inhalation study in rats. Pauluhn, J., Mohr, U. J. Appl. Toxicol (2006)
- Acute nose-only exposure of rats to phosgene. Part I: concentration x time dependence of LC50s, nonlethal-threshold concentrations, and analysis of breathing patterns. Pauluhn, J. Inhal. Toxicol (2006)
- Analysis of biomarkers in rats and dogs exposed to polymeric methylenediphenyl diisocyanate (pMDI) and its glutathione adduct. Pauluhn, J., Brown, W.E., Hext, P., Leibold, E., Leng, G. Toxicology (2006)
- Acute nose-only exposure of rats to phosgene. Part II. Concentration x time dependence of changes in bronchoalveolar lavage during a follow-up period of 3 months. Pauluhn, J. Inhal. Toxicol (2006)
- Acute head-only exposure of dogs to phosgene. Part III. Comparison of indicators of lung injury in dogs and rats. Pauluhn, J. Inhal. Toxicol (2006)
- Partial C-fiber ablation modulates diphenylmethane-4,4'-diisocyanate (MDI)-induced respiratory allergy in Brown Norway rats. Pauluhn, J., Vohr, H.W. Toxicology (2006)
- Subacute inhalation toxicity of 2-chloro-4-toluidine in rats. Pauluhn, J. Inhal. Toxicol (2006)
- Inhaled cationic amphiphilic drug-induced pulmonary phospholipidosis in rats and dogs: time-course and dose-response of biomarkers of exposure and effect. Pauluhn, J. Toxicology (2005)
- Repeated inhalation challenge with diphenylmethane-4,4'-diisocyanate in brown Norway rats leads to a time-related increase of neutrophils in bronchoalveolar lavage after topical induction. Pauluhn, J., Woolhiser, M.R., Bloemen, L. Inhal. Toxicol (2005)
- Experimental approaches to evaluate respiratory allergy in animal models. Pauluhn, J., Mohr, U. Exp. Toxicol. Pathol. (2005)
- Retrospective analysis of acute inhalation toxicity studies: comparison of actual concentrations by filter and cascade impactor analyses. Pauluhn, J. Regul. Toxicol. Pharmacol. (2005)
- Concentration-dependence of aniline-induced methemoglobinemia in dogs: a derivation of an acute reference concentration. Pauluhn, J. Toxicology (2005)
- Brown Norway rat asthma model of diphenylmethane 4,4'-diisocyanate. Pauluhn, J. Inhal. Toxicol (2005)
- Subacute inhalation toxicity of aniline in rats: analysis of time-dependence and concentration-dependence of hematotoxic and splenic effects. Pauluhn, J. Toxicol. Sci. (2004)
- Comparative analysis of pulmonary irritation by measurements of Penh and protein in bronchoalveolar lavage fluid in brown Norway rats and Wistar rats exposed to irritant aerosols. Pauluhn, J. Inhal. Toxicol (2004)
- Pulmonary irritant potency of polyisocyanate aerosols in rats: comparative assessment of irritant threshold concentrations by bronchoalveolar lavage. Pauluhn, J. J. Appl. Toxicol (2004)
