Kenneth A. Jacobson
Molecular Recognition Section
Laboratory of Bioorganic Chemistry
National Institutes of Diabetes and Digestive and Kidney Diseases
National Institutes of Health
USA
Name/email consistency: high
- New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors. Jacobson, K.A., Costanzi, S. Mol. Pharmacol. (2012)
- G protein-coupled adenosine (P1) and P2Y receptors: ligand design and receptor interactions. Jacobson, K.A., Balasubramanian, R., Deflorian, F., Gao, Z.G. Purinergic Signal. (2012)
- Pharmacochemistry of the platelet purinergic receptors. Jacobson, K.A., Deflorian, F., Mishra, S., Costanzi, S. Purinergic Signal. (2011)
- Nucleoside conjugates of quantum dots for characterization of G protein-coupled receptors: strategies for immobilizing A2A adenosine receptor agonists. Das, A., Sanjayan, G.J., Kecskés, M., Yoo, L., Gao, Z.G., Jacobson, K.A. J. Nanobiotechnology (2010)
- P2Y nucleotide receptors: promise of therapeutic applications. Jacobson, K.A., Boeynaems, J.M. Drug Discov. Today (2010)
- GPCR ligand-dendrimer (GLiDe) conjugates: future smart drugs? Jacobson, K.A. Trends Pharmacol. Sci. (2010)
- Medicinal chemistry of the A3 adenosine receptor: agonists, antagonists, and receptor engineering. Jacobson, K.A., Klutz, A.M., Tosh, D.K., Ivanov, A.A., Preti, D., Baraldi, P.G. Handb. Exp. Pharmacol (2009)
- Introduction to adenosine receptors as therapeutic targets. Jacobson, K.A. Handb. Exp. Pharmacol (2009)
- Development of selective agonists and antagonists of P2Y receptors. Jacobson, K.A., Ivanov, A.A., de Castro, S., Harden, T.K., Ko, H. Purinergic Signal. (2009)
- Preface: special issue on medicinal chemistry of purines. Jacobson, K.A., Zablocki, J., Bhagwat, S. Purinergic Signal. (2009)
- Enhanced A3 adenosine receptor selectivity of multivalent nucleoside-dendrimer conjugates. Klutz, A.M., Gao, Z.G., Lloyd, J., Shainberg, A., Jacobson, K.A. J. Nanobiotechnology (2008)
- Neoceptors: reengineering GPCRs to recognize tailored ligands. Jacobson, K.A., Gao, Z.G., Liang, B.T. Trends Pharmacol. Sci. (2007)
- Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5'-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Jacobson, K.A., Costanzi, S., Ivanov, A.A., Tchilibon, S., Besada, P., Gao, Z.G., Maddileti, S., Harden, T.K. Biochem. Pharmacol. (2006)
- Adenosine receptors as therapeutic targets. Jacobson, K.A., Gao, Z.G. Nat. Rev. Drug. Discov (2006)
- Action of nucleosides and nucleotides at 7 transmembrane-spanning receptors. Jacobson, K.A., Costanzi, S., Kim, S.K., Roh, E., Joshi, B.V., Tchilibon, S., Duong, H.T., Gao, Z.G. Nucleosides. Nucleotides. Nucleic. Acids (2006)
- A neoceptor approach to unraveling microscopic interactions between the human A2A adenosine receptor and its agonists. Jacobson, K.A., Ohno, M., Duong, H.T., Kim, S.K., Tchilibon, S., Cesnek, M., Holý, A., Gao, Z.G. Chem. Biol. (2005)
- Molecular recognition at adenine nucleotide (P2) receptors in platelets. Jacobson, K.A., Mamedova, L., Joshi, B.V., Besada, P., Costanzi, S. Semin. Thromb. Hemost. (2005)
- Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection. Jacobson, K.A., Gao, Z.G., Tchilibon, S., Duong, H.T., Joshi, B.V., Sonin, D., Liang, B.T. J. Med. Chem. (2005)
- Molecular recognition at purine and pyrimidine nucleotide (P2) receptors. Jacobson, K.A., Costanzi, S., Ohno, M., Joshi, B.V., Besada, P., Xu, B., Tchilibon, S. Curr. Top. Med. Chem (2004)
- Interactions of flavones and other phytochemicals with adenosine receptors. Jacobson, K.A., Moro, S., Manthey, J.A., West, P.L., Ji, X.D. Adv. Exp. Med. Biol. (2002)
- Structurally related nucleotides as selective agonists and antagonists at P2Y1 receptors. Jacobson, K.A., Moro, S., Hoffmann, C., Kim, Y.C., Kim, H.S., Ravi, R.G., Harden, T.K., Boyer, J.L. Farmaco (2001)
- Neoceptor concept based on molecular complementarity in GPCRs: a mutant adenosine A(3) receptor with selectively enhanced affinity for amine-modified nucleosides. Jacobson, K.A., Gao, Z.G., Chen, A., Barak, D., Kim, S.A., Lee, K., Link, A., Rompaey, P.V., van Calenbergh, S., Liang, B.T. J. Med. Chem. (2001)
- Methanocarba analogues of purine nucleosides as potent and selective adenosine receptor agonists. Jacobson, K.A., Ji, X., Li, A.H., Melman, N., Siddiqui, M.A., Shin, K.J., Marquez, V.E., Ravi, R.G. J. Med. Chem. (2000)
- In search of selective P2 receptor ligands: interaction of dihydropyridine derivatives at recombinant rat P2X(2) receptors. Jacobson, K.A., Kim, Y.C., King, B.F. J. Auton. Nerv. Syst. (2000)
- A novel pharmacological approach to treating cardiac ischemia. Binary conjugates of A1 and A3 adenosine receptor agonists. Jacobson, K.A., Xie, R., Young, L., Chang, L., Liang, B.T. J. Biol. Chem. (2000)
- Molecular recognition in P2 receptors: ligand development aided by molecular modeling and mutagenesis. Jacobson, K.A., Hoffmann, C., Kim, Y.C., Camaioni, E., Nandanan, E., Jang, S.Y., Guo, D.P., Ji, X.D., von Kügelgen, I., Moro, S., Ziganshin, A.U., Rychkov, A., King, B.F., Brown, S.G., Wildman, S.S., Burnstock, G., Boyer, J.L., Mohanram, A., Harden, T.K. Prog. Brain Res. (1999)
- A pyridoxine cyclic phosphate and its 6-azoaryl derivative selectively potentiate and antagonize activation of P2X1 receptors. Jacobson, K.A., Kim, Y.C., Wildman, S.S., Mohanram, A., Harden, T.K., Boyer, J.L., King, B.F., Burnstock, G. J. Med. Chem. (1998)
- Pharmacological characterization of novel A3 adenosine receptor-selective antagonists. Jacobson, K.A., Park, K.S., Jiang, J.L., Kim, Y.C., Olah, M.E., Stiles, G.L., Ji, X.D. Neuropharmacology (1997)
