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Karel Allegaert

Neonatal Intensive Care Unit

University Hospitals Leuven




Name/email consistency: high



  • Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium. 2002 - 2012


  1. Creatinine reference values in ELBW infants: impact of quantification by Jaffe or enzymatic method. Allegaert, K., Kuppens, M., Mekahli, D., Levtchenko, E., Vanstapel, F., Vanhole, C., van den Anker, J.N. J. Matern. Fetal. Neonatal. Med. (2012) [Pubmed]
  2. Pharmacokinetics and pharmacodynamics of intravenous acetaminophen in neonates. Allegaert, K., van den Anker, J. Expert. Rev. Clin. Pharmacol (2011) [Pubmed]
  3. The pharmacokinetics of intravenous paracetamol in neonates: size matters most. Allegaert, K., Palmer, G.M., Anderson, B.J. Arch. Dis. Child. (2011) [Pubmed]
  4. Developmental pharmacology of tramadol during infancy: ontogeny, pharmacogenetics and elimination clearance. Allegaert, K., Rochette, A., Veyckemans, F. Paediatr. Anaesth (2011) [Pubmed]
  5. Mechanism based medicine in infancy: complex interplay between developmental pharmacology and pharmacogenetics. Allegaert, K. Int. J. Clin. Pharm (2011) [Pubmed]
  6. Prospective assessment of short-term propylene glycol tolerance in neonates. Allegaert, K., Vanhaesebrouck, S., Kulo, A., Cosaert, K., Verbesselt, R., Debeer, A., de Hoon, J. Arch. Dis. Child. (2010) [Pubmed]
  7. Haemodynamics of intravenous paracetamol in neonates. Allegaert, K., Naulaers, G. Eur. J. Clin. Pharmacol. (2010) [Pubmed]
  8. Is propofol the perfect hypnotic agent for procedural sedation in neonates? Allegaert, K. Curr. Clin. Pharmacol (2009) [Pubmed]
  9. In vivo glucuronidation activity of drugs in neonates: extensive interindividual variability despite their young age. Allegaert, K., Vanhaesebrouck, S., Verbesselt, R., van den Anker, J.N. Ther. Drug. Monit (2009) [Pubmed]
  10. Clinical practice: analgesia in neonates. Allegaert, K., Veyckemans, F., Tibboel, D. Eur. J. Pediatr. (2009) [Pubmed]
  11. Cefazolin pharmacokinetics in maternal plasma and amniotic fluid during pregnancy. Allegaert, K., van Mieghem, T., Verbesselt, R., de Hoon, J., Rayyan, M., Devlieger, R., Deprest, J., Anderson, B.J. Am. J. Obstet. Gynecol. (2009) [Pubmed]
  12. The impact of ibuprofen or indomethacin on renal drug clearance in neonates. Allegaert, K. J. Matern. Fetal. Neonatal. Med. (2009) [Pubmed]
  13. Cefazolin plasma protein binding saturability during pregnancy. Allegaert, K., Van Mieghem, T., Verbesselt, R., Vanhole, C., Devlieger, R., Cossey, V., Deprest, J., de Hoon, J. Methods. Find. Exp. Clin. Pharmacol (2009) [Pubmed]
  14. Covariates of tramadol disposition in the first months of life. Allegaert, K., van den Anker, J.N., de Hoon, J.N., van Schaik, R.H., Debeer, A., Tibboel, D., Naulaers, G., Anderson, B.J. Br. J. Anaesth (2008) [Pubmed]
  15. Urinary propofol metabolites in early life after single intravenous bolus. Allegaert, K., Vancraeynest, J., Rayyan, M., de Hoon, J., Cossey, V., Naulaers, G., Verbesselt, R. Br. J. Anaesth (2008) [Pubmed]
  16. Neonatal clinical pharmacology: recent observations of relevance for anaesthesiologists. Allegaert, K., de Hoon, J., Naulaers, G., Van De Velde, M. Acta. Anaesthesiol. Belg (2008) [Pubmed]
  17. Postmenstrual age and CYP2D6 polymorphisms determine tramadol o-demethylation in critically ill neonates and infants. Allegaert, K., van Schaik, R.H., Vermeersch, S., Verbesselt, R., Cossey, V., Vanhole, C., van Fessem, M., de Hoon, J., van den Anker, J.N. Pediatr. Res. (2008) [Pubmed]
  18. Both postnatal and postmenstrual age contribute to the interindividual variability in tramadol glucuronidation in neonates. Allegaert, K., Vanhole, C., Vermeersch, S., Rayyan, M., Verbesselt, R., de Hoon, J. Early Hum. Dev. (2008) [Pubmed]
  19. Cerebrospinal fluid compartmental pharmacokinetics of amikacin in neonates. Allegaert, K., Scheers, I., Adams, E., Brajanoski, G., Cossey, V., Anderson, B.J. Antimicrob. Agents Chemother. (2008) [Pubmed]
  20. Covariates of amikacin clearance in neonates: the impact of postnatal age on predictability. Allegaert, K., Scheers, I., Cossey, V., Anderson, B.J. Drug. Metab. Lett (2008) [Pubmed]
  21. Developmental pharmacology: neonates are not just small adults... Allegaert, K., Verbesselt, R., Naulaers, G., van den Anker, J.N., Rayyan, M., Debeer, A., de Hoon, J. Acta. Clin. Belg (2008) [Pubmed]
  22. Determinants of drug metabolism in early neonatal life. Allegaert, K., van den Anker, J.N., Naulaers, G., de Hoon, J. Curr. Clin. Pharmacol (2007) [Pubmed]
  23. Renal drug clearance in preterm neonates: relation to prenatal growth. Allegaert, K., Anderson, B.J., van den Anker, J.N., Vanhaesebrouck, S., de Zegher, F. Ther. Drug. Monit (2007) [Pubmed]
  24. Urinary metabolites to assess in vivo ontogeny of hepatic drug metabolism in early neonatal life. Allegaert, K., Verbesselt, R., Rayyan, M., Debeer, A., de Hoon, J. Methods. Find. Exp. Clin. Pharmacol (2007) [Pubmed]
  25. Inter-individual variability in propofol pharmacokinetics in preterm and term neonates. Allegaert, K., Peeters, M.Y., Verbesselt, R., Tibboel, D., Naulaers, G., de Hoon, J.N., Knibbe, C.A. Br. J. Anaesth (2007) [Pubmed]
  26. Limited predictability of amikacin clearance in extreme premature neonates at birth. Allegaert, K., Anderson, B.J., Cossey, V., Holford, N.H. Br. J. Clin. Pharmacol (2006) [Pubmed]
  27. Contribution of glucuronidation to tramadol disposition in early neonatal life. Allegaert, K., Rayyan, M., de Hoon, J., Tibboel, D., Verbesselt, R., Naulaers, G., Van den Anker, J.N., Devlieger, H. Basic Clin. Pharmacol. Toxicol. (2006) [Pubmed]
  28. Levetiracetam pharmacokinetics in neonates at birth. Allegaert, K., Lewi, L., Naulaers, G., Lagae, L. Epilepsia (2006) [Pubmed]
  29. Cryotherapy versus laser photocoagulation for threshold retinopathy of prematurity: impact on early postoperative clinical recovery. Allegaert, K., Van de Velde, M., Debeer, A., Casteels, I., Devlieger, H. Bull. Soc. Belge. Ophtalmol (2006) [Pubmed]
  30. Maturational changes in the in vivo activity of CYP3A4 in the first months of life. Allegaert, K., Van den Anker, J.N., Debeer, A., Cossey, V., Verbesselt, R., Tibboel, D., Devlieger, H., de Hoon, J. Int. J. Clin. Pharmacol. Ther (2006) [Pubmed]
  31. Impact of ibuprofen administration on renal drug clearance in the first weeks of life. Allegaert, K., Rayyan, M., Anderson, B.J. Methods. Find. Exp. Clin. Pharmacol (2006) [Pubmed]
  32. Tramadol concentrations in blood and in cerebrospinal fluid in a neonate. Allegaert, K., de Hoon, J., Verbesselt, R., Devlieger, H., Tibboel, D. Eur. J. Clin. Pharmacol. (2005) [Pubmed]
  33. The impact of ibuprofen on renal clearance in preterm infants is independent of the gestational age. Allegaert, K., Cossey, V., Debeer, A., Langhendries, J.P., Van Overmeire, B., de Hoon, J., Devlieger, H. Pediatr. Nephrol. (2005) [Pubmed]
  34. Pharmacodynamics of chloral hydrate in former preterm infants. Allegaert, K., Daniels, H., Naulaers, G., Tibboel, D., Devlieger, H. Eur. J. Pediatr. (2005) [Pubmed]
  35. Tramadol disposition in the very young: an attempt to assess in vivo cytochrome P-450 2D6 activity. Allegaert, K., Anderson, B.J., Verbesselt, R., Debeer, A., de Hoon, J., Devlieger, H., Van Den Anker, J.N., Tibboel, D. Br. J. Anaesth (2005) [Pubmed]
  36. Nonselective cyclo-oxygenase inhibitors and glomerular filtration rate in preterm neonates. Allegaert, K., Vanhole, C., de Hoon, J., Guignard, J.P., Tibboel, D., Devlieger, H., Van Overmeire, B. Pediatr. Nephrol. (2005) [Pubmed]
  37. Variability in pain expression characteristics in former preterm infants. Allegaert, K., Devlieger, H., Bulckaert, D., Naulaers, G., Casaer, P., Tibboel, D. J. Perinat. Med (2005) [Pubmed]
  38. Intra- and interindividual variability of glucuronidation of paracetamol during repeated administration of propacetamol in neonates. Allegaert, K., de Hoon, J., Verbesselt, R., Vanhole, C., Devlieger, H., Tibboel, D. Acta Paediatr. (2005) [Pubmed]
  39. O-demethylation of tramadol in the first months of life. Allegaert, K., Van den Anker, J.N., Verbesselt, R., de Hoon, J., Vanhole, C., Tibboel, D., Devlieger, H. Eur. J. Clin. Pharmacol. (2005) [Pubmed]
  40. Pharmacokinetics of single dose intravenous propacetamol in neonates: effect of gestational age. Allegaert, K., Van der Marel, C.D., Debeer, A., Pluim, M.A., Van Lingen, R.A., Vanhole, C., Tibboel, D., Devlieger, H. Arch. Dis. Child. Fetal Neonatal Ed. (2004) [Pubmed]
  41. Threshold retinopathy at threshold of viability: the EpiBel study. Allegaert, K., de Coen, K., Devlieger, H. Br. J. Ophthalmol (2004) [Pubmed]
  42. Intravenous paracetamol (propacetamol) pharmacokinetics in term and preterm neonates. Allegaert, K., Anderson, B.J., Naulaers, G., de Hoon, J., Verbesselt, R., Debeer, A., Devlieger, H., Tibboel, D. Eur. J. Clin. Pharmacol. (2004) [Pubmed]
  43. The use of methohexital during chest tube removal in neonates. Allegaert, K., Naulaers, G., Debeer, A., Breysem, L., Ferens, I., Vanhole, C., Devlieger, H., Tibboel, D. Paediatr. Anaesth (2004) [Pubmed]
  44. Effects of co-administration of ibuprofen-lysine on the pharmacokinetics of amikacin in preterm infants during the first days of life. Allegaert, K., Cossey, V., Langhendries, J.P., Naulaers, G., Vanhole, C., Devlieger, H., Van Overmeire, B. Biol. Neonate (2004) [Pubmed]
  45. Systematic evaluation of pain in neonates: effect on the number of intravenous analgesics prescribed. Allegaert, K., Tibboel, D., Naulaers, G., Tison, D., De Jonge, A., Van Dijk, M., Vanhole, C., Devlieger, H. Eur. J. Clin. Pharmacol. (2003) [Pubmed]
  46. Incidence, perinatal risk factors, visual outcome and management of threshold retinopathy. Allegaert, K., Verdonck, N., Vanhole, C., de Halleux, V., Naulaers, G., Cossey, V., Devlieger, H., Casteels, I. Bull. Soc. Belge. Ophtalmol (2003) [Pubmed]
  47. Retinopathy of prematurity: any difference in risk factors between a high and low risk population?. Allegaert, K., Casteels, I., Cossey, V., Devlieger, H. Eur. J. Ophthalmol (2003) [Pubmed]
  48. The use of methohexital during neonatal cardioversion. Allegaert, K., Naulaers, G., Gewillig, M., Devlieger, H. Paediatr. Anaesth (2002) [Pubmed]
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