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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Keith R. Laderoute

SRI International

Menlo Park



Name/email consistency: high



  • SRI International, Menlo Park, USA. 2010
  • Biosciences Division, SRI International, Bldg. L, Rm. A258, USA. 2005 - 2006
  • Pharmaceutical Discovery Division, SRI International, Menlo Park, California 94025, USA. 1999 - 2004
  • SRI International, 333 Ravenswood Avenue, Menlo Park, California 94025, USA. 2001


  1. SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK). Laderoute, K.R., Calaoagan, J.M., Madrid, P.B., Klon, A.E., Ehrlich, P.J. Cancer Biol. Ther. (2010) [Pubmed]
  2. 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Laderoute, K.R., Amin, K., Calaoagan, J.M., Knapp, M., Le, T., Orduna, J., Foretz, M., Viollet, B. Mol. Cell. Biol. (2006) [Pubmed]
  3. The interaction between HIF-1 and AP-1 transcription factors in response to low oxygen. Laderoute, K.R. Semin. Cell Dev. Biol. (2005) [Pubmed]
  4. Glucose utilization is essential for hypoxia-inducible factor 1 alpha-dependent phosphorylation of c-Jun. Laderoute, K.R., Calaoagan, J.M., Knapp, M., Johnson, R.S. Mol. Cell. Biol. (2004) [Pubmed]
  5. The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent. Laderoute, K.R., Calaoagan, J.M., Gustafson-Brown, C., Knapp, A.M., Li, G.C., Mendonca, H.L., Ryan, H.E., Wang, Z., Johnson, R.S. Mol. Cell. Biol. (2002) [Pubmed]
  6. c-jun cooperates with SV40 T-antigen to sustain MMP-2 expression in immortalized cells. Laderoute, K.R., Calaoagan, J.M., Knapp, A.M., Mendonca, H.L., Johnson, R.S. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  7. Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Laderoute, K.R., Alarcon, R.M., Brody, M.D., Calaoagan, J.M., Chen, E.Y., Knapp, A.M., Yun, Z., Denko, N.C., Giaccia, A.J. Clin. Cancer Res. (2000) [Pubmed]
  8. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. Laderoute, K.R., Mendonca, H.L., Calaoagan, J.M., Knapp, A.M., Giaccia, A.J., Stork, P.J. J. Biol. Chem. (1999) [Pubmed]
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