Keith R. Laderoute
SRI International
Menlo Park
USA
Name/email consistency: high
- SU11248 (sunitinib) directly inhibits the activity of mammalian 5'-AMP-activated protein kinase (AMPK). Laderoute, K.R., Calaoagan, J.M., Madrid, P.B., Klon, A.E., Ehrlich, P.J. Cancer Biol. Ther. (2010)
- 5'-AMP-activated protein kinase (AMPK) is induced by low-oxygen and glucose deprivation conditions found in solid-tumor microenvironments. Laderoute, K.R., Amin, K., Calaoagan, J.M., Knapp, M., Le, T., Orduna, J., Foretz, M., Viollet, B. Mol. Cell. Biol. (2006)
- The interaction between HIF-1 and AP-1 transcription factors in response to low oxygen. Laderoute, K.R. Semin. Cell Dev. Biol. (2005)
- Glucose utilization is essential for hypoxia-inducible factor 1 alpha-dependent phosphorylation of c-Jun. Laderoute, K.R., Calaoagan, J.M., Knapp, M., Johnson, R.S. Mol. Cell. Biol. (2004)
- The response of c-jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1 alpha dependent. Laderoute, K.R., Calaoagan, J.M., Gustafson-Brown, C., Knapp, A.M., Li, G.C., Mendonca, H.L., Ryan, H.E., Wang, Z., Johnson, R.S. Mol. Cell. Biol. (2002)
- c-jun cooperates with SV40 T-antigen to sustain MMP-2 expression in immortalized cells. Laderoute, K.R., Calaoagan, J.M., Knapp, A.M., Mendonca, H.L., Johnson, R.S. Biochem. Biophys. Res. Commun. (2001)
- Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Laderoute, K.R., Alarcon, R.M., Brody, M.D., Calaoagan, J.M., Chen, E.Y., Knapp, A.M., Yun, Z., Denko, N.C., Giaccia, A.J. Clin. Cancer Res. (2000)
- Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. Laderoute, K.R., Mendonca, H.L., Calaoagan, J.M., Knapp, A.M., Giaccia, A.J., Stork, P.J. J. Biol. Chem. (1999)