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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Mark Frederick McCarty

NutriGuard Research

1051 Hermes Ave.


CA 92024

United States


Name/email consistency: high



  • NutriGuard Research, 1051 Hermes Ave., Encinitas, CA 92024, United States. 2010
  • Oasis of Hope Hospital, Playas de Tijuana, Tijuana, B.C. 22504, Mexico. 2010
  • NutriGuard Research, Encinitas CA 92024, USA. 2004 - 2010
  • Oasis of Hope Hospital, Tijuana, Mexico. 2007 - 2010
  • Natural Alternatives International, 1185 Linda Vista Dr., San Marcos, CA 92078, USA. 2006 - 2009
  • Block Center for Integrative Cancer Care, Evanston, Illinois 60201, USA. 2005 - 2006
  • Pantox Laboratories, San Diego, CA 92109, USA. 2003 - 2005


  1. Dietary saturate/unsaturate ratio as a determinant of adiposity. McCarty, M.F. Med. Hypotheses (2010) [Pubmed]
  2. Oxidative stress therapy for solid tumors - a proposal. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2010) [Pubmed]
  3. Potential utility of full-spectrum antioxidant therapy, citrulline, and dietary nitrate in the management of sickle cell disease. McCarty, M.F. Med. Hypotheses (2010) [Pubmed]
  4. Potential complementarity of high-flavanol cocoa powder and spirulina for health protection. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2010) [Pubmed]
  5. Practical strategies for suppressing hypoxia-inducible factor activity in cancer therapy. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2010) [Pubmed]
  6. Practical prevention of cardiac remodeling and atrial fibrillation with full-spectrum antioxidant therapy and ancillary strategies. McCarty, M.F. Med. Hypotheses (2010) [Pubmed]
  7. Salsalate may have broad utility in the prevention and treatment of vascular disorders and the metabolic syndrome. McCarty, M.F. Med. Hypotheses (2010) [Pubmed]
  8. Practical strategies for targeting NF-kappaB and NADPH oxidase may improve survival during lethal influenza epidemics. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2010) [Pubmed]
  9. Oral phycocyanobilin may diminish the pathogenicity of activated brain microglia in neurodegenerative disorders. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2010) [Pubmed]
  10. The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2009) [Pubmed]
  11. The "rejuvenatory" impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2009) [Pubmed]
  12. Genistein and phycocyanobilin may prevent hepatic fibrosis by suppressing proliferation and activation of hepatic stellate cells. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2009) [Pubmed]
  13. Activation of AMP-activated kinase as a strategy for managing autosomal dominant polycystic kidney disease. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2009) [Pubmed]
  14. Poor vitamin D status may contribute to high risk for insulin resistance, obesity, and cardiovascular disease in Asian Indians. McCarty, M.F. Med. Hypotheses (2009) [Pubmed]
  15. High-dose folate and dietary purines promote scavenging of peroxynitrite-derived radicals--clinical potential in inflammatory disorders. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2009) [Pubmed]
  16. AMP-activated kinase may suppress NADPH oxidase activation in vascular tissues. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2009) [Pubmed]
  17. The hyperpolarizing impact of glycine on endothelial cells may be anti-atherogenic. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2009) [Pubmed]
  18. Can moderate elevations of parathyroid hormone acutely increase risk for ischemic cardiac arrhythmias? McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2009) [Pubmed]
  19. Scavenging of peroxynitrite-derived radicals by flavonoids may support endothelial NO synthase activity, contributing to the vascular protection associated with high fruit and vegetable intakes. McCarty, M.F. Med. Hypotheses (2008) [Pubmed]
  20. PPAR gamma agonists can be expected to potentiate the efficacy of metronomic chemotherapy through CD36 up-regulation. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2008) [Pubmed]
  21. Gamma-tocopherol may promote effective no synthase function by protecting tetrahydrobiopterin from peroxynitrite. McCarty, M.F. Med. Hypotheses (2007) [Pubmed]
  22. ''Iatrogenic Gilbert syndrome''--a strategy for reducing vascular and cancer risk by increasing plasma unconjugated bilirubin. McCarty, M.F. Med. Hypotheses (2007) [Pubmed]
  23. Neuroprotective potential of the Bahadori leanness program: a "mini-fast with exercise" strategy. McCarty, M.F., Falahati-Nini, A. Med. Hypotheses (2007) [Pubmed]
  24. Clinical potential of Spirulina as a source of phycocyanobilin. McCarty, M.F. J. Med. Food (2007) [Pubmed]
  25. Oster rediscovered--mega-dose folate for symptomatic atherosclerosis. McCarty, M.F. Med. Hypotheses (2007) [Pubmed]
  26. A two-phase strategy for treatment of oxidant-dependent cancers. McCarty, M.F., Barroso-Aranda, J., Contreras, F. Med. Hypotheses (2007) [Pubmed]
  27. High-dose folate may improve platelet function in acute coronary syndrome and other pathologies associated with increased platelet oxidative stress. McCarty, M.F. Med. Hypotheses (2007) [Pubmed]
  28. Exenatide and biotin in conjunction with a protein-sparing fast for normalization of beta cell function in type 2 diabetics. McCarty, M.F. Med. Hypotheses (2007) [Pubmed]
  29. PKC-mediated modulation of L-type calcium channels may contribute to fat-induced insulin resistance. McCarty, M.F. Med. Hypotheses (2006) [Pubmed]
  30. Induction of heat shock proteins may combat insulin resistance. McCarty, M.F. Med. Hypotheses (2006) [Pubmed]
  31. cGMP may have trophic effects on beta cell function comparable to those of cAMP, implying a role for high-dose biotin in prevention/treatment of diabetes. McCarty, M.F. Med. Hypotheses (2006) [Pubmed]
  32. Down-regulation of microglial activation may represent a practical strategy for combating neurodegenerative disorders. McCarty, M.F. Med. Hypotheses (2006) [Pubmed]
  33. Isoflavones made simple - genistein's agonist activity for the beta-type estrogen receptor mediates their health benefits. McCarty, M.F. Med. Hypotheses (2006) [Pubmed]
  34. Rationale for a novel nutraceutical complex 'K-water': potassium taurine bicarbonate (PTB). McCarty, M.F. Med. Hypotheses (2006) [Pubmed]
  35. Toward a core nutraceutical program for cancer management. McCarty, M.F., Block, K.I. Integr. Cancer. Ther (2006) [Pubmed]
  36. Adjuvant strategies for prevention of glomerulosclerosis. McCarty, M.F. Med. Hypotheses (2006) [Pubmed]
  37. Toward prevention of Alzheimers disease--potential nutraceutical strategies for suppressing the production of amyloid beta peptides. McCarty, M.F. Med. Hypotheses (2006) [Pubmed]
  38. Nutraceutical resources for diabetes prevention--an update. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  39. Acid-base balance may influence risk for insulin resistance syndrome by modulating cortisol output. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  40. Low-insulin-response diets may decrease plasma C-reactive protein by influencing adipocyte function. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  41. De novo synthesis of diacylglycerol in endothelium may mediate the association between PAI-1 and the insulin resistance syndrome. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  42. The low-AGE content of low-fat vegan diets could benefit diabetics - though concurrent taurine supplementation may be needed to minimize endogenous AGE production. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  43. Up-regulation of PPARgamma coactivator-1alpha as a strategy for preventing and reversing insulin resistance and obesity. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  44. Potential utility of natural polyphenols for reversing fat-induced insulin resistance. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  45. An ezetimibe-policosanol combination has the potential to be an OTC agent that could dramatically lower LDL cholesterol without side effects. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  46. A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy coffee consumption on diabetes risk. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  47. Marinobufagenin may mediate the impact of salty diets on left ventricular hypertrophy by disrupting the protective function of coronary microvascular endothelium. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  48. Nutritional modulation of parathyroid hormone secretion may influence risk for left ventricular hypertrophy. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  49. Secondary hyperparathyroidism promotes the acute phase response -- a rationale for supplemental vitamin D in prevention of vascular events in the elderly. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  50. Marinobufagenin may mediate the adverse impact of salty diets on renal calcium retention by impairing the efficiency of renal tubular sodium-calcium exchange. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  51. Supplemental arginine and high-dose folate may promote bone health by supporting the activity of endothelial-type nitric oxide synthase in bone. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  52. AMPK activation as a strategy for reversing the endothelial lipotoxicity underlying the increased vascular risk associated with insulin resistance syndrome. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  53. High mitochondrial redox potential may promote induction and activation of UCP2 in hepatocytes during hepatothermic therapy. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  54. Chromium picolinate may favorably influence the vascular risk associated with smoking by combating cortisol-induced insulin resistance. McCarty, M.F. Med. Hypotheses (2005) [Pubmed]
  55. Multifocal angiostatic therapy: an update. McCarty, M.F., Block, K.I. Integr. Cancer. Ther (2005) [Pubmed]
  56. A shift in myocardial substrate, improved endothelial function, and diminished sympathetic activity may contribute to the anti-anginal impact of very-low-fat diets. McCarty, M.F. Med. Hypotheses (2004) [Pubmed]
  57. AMPK activation may suppress hepatic production of C-reactive protein by stimulating nitric oxide synthase. McCarty, M.F. Med. Hypotheses (2004) [Pubmed]
  58. Chronic activation of AMP-activated kinase as a strategy for slowing aging. McCarty, M.F. Med. Hypotheses (2004) [Pubmed]
  59. Does bitter melon contain an activator of AMP-activated kinase?. McCarty, M.F. Med. Hypotheses (2004) [Pubmed]
  60. Supplementary taurine may stabilize atheromatous plaque by antagonizing the activation of metalloproteinases by hypochlorous acid. McCarty, M.F. Med. Hypotheses (2004) [Pubmed]
  61. A taurine-supplemented vegan diet may blunt the contribution of neutrophil activation to acute coronary events. McCarty, M.F. Med. Hypotheses (2004) [Pubmed]
  62. Targeting multiple signaling pathways as a strategy for managing prostate cancer: multifocal signal modulation therapy. McCarty, M.F. Integr. Cancer. Ther (2004) [Pubmed]
  63. The A54T polymorphism of fatty acid-binding protein 2 may entail a reduction in fat-stimulated secretion of GIP that potentiates the adverse impact of fatty diets on insulin sensitivity. McCarty, M.F. Med. Hypotheses (2003) [Pubmed]
  64. Turning an 'Achilles' Heel' into an asset--activation of HIF-1alpha during angiostatic therapy will increase tumor sensitivity to iron-catalyzed oxidative damage. McCarty, M.F. Med. Hypotheses (2003) [Pubmed]
  65. PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. McCarty, M.F., Thomas, C.A. Med. Hypotheses (2003) [Pubmed]
  66. A moderately low phosphate intake may provide health benefits analogous to those conferred by UV light - a further advantage of vegan diets. McCarty, M.F. Med. Hypotheses (2003) [Pubmed]
  67. Iatrogenic lipodystrophy in HIV patients - the need for very-low-fat diets. McCarty, M.F. Med. Hypotheses (2003) [Pubmed]
  68. Hyperinsulinemia may boost both hematocrit and iron absorption by up-regulating activity of hypoxia-inducible factor-1alpha. McCarty, M.F. Med. Hypotheses (2003) [Pubmed]
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