Natesan Murugesan
Department of Chemistry
Bristol-Myers Squibb Pharmaceutical Research Institute
Princeton
New Jersey 08543-5400
USA
Name/email consistency: high
- Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective antagonist. Murugesan, N., Gu, Z., Spergel, S., Young, M., Chen, P., Mathur, A., Leith, L., Hermsmeier, M., Liu, E.C., Zhang, R., Bird, E., Waldron, T., Marino, A., Koplowitz, B., Humphreys, W.G., Chong, S., Morrison, R.A., Webb, M.L., Moreland, S., Trippodo, N., Barrish, J.C. J. Med. Chem. (2003)
- Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists. Murugesan, N., Gu, Z., Stein, P.D., Spergel, S., Mathur, A., Leith, L., Liu, E.C., Zhang, R., Bird, E., Waldron, T., Marino, A., Morrison, R.A., Webb, M.L., Moreland, S., Barrish, J.C. J. Med. Chem. (2000)
- Biphenylsulfonamide endothelin antagonists: structure-activity relationships of a series of mono- and disubstituted analogues and pharmacology of the orally active endothelin antagonist 2'-amino-N- (3,4-dimethyl-5-isoxazolyl)-4'-(2-methylpropyl)[1, 1'-biphenyl]-2-sulfonamide (BMS-187308). Murugesan, N., Gu, Z., Stein, P.D., Bisaha, S., Spergel, S., Girotra, R., Lee, V.G., Lloyd, J., Misra, R.N., Schmidt, J., Mathur, A., Stratton, L., Kelly, Y.F., Bird, E., Waldron, T., Liu, E.C., Zhang, R., Lee, H., Serafino, R., Abboa-Offei, B., Mathers, P., Giancarli, M., Seymour, A.A., Webb, M.L., Hunt, J.T. J. Med. Chem. (1998)
