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Najam A. Sharif

Pharmaceutical Research

Alcon Research

Ltd., Fort Worth

Texas 76134



Name/email consistency: high



  • Pharmaceutical Research, Alcon Research, Ltd., Fort Worth, Texas 76134, USA. 2000 - 2011


  1. Intracellular signaling in human iridial fibroblasts and iridial melanocytes in response to prostaglandins, endothelin, isoproterenol, and other pharmacological agents. Sharif, N.A., Crider, J.Y. Curr. Eye Res. (2011) [Pubmed]
  2. Serotonin-2 receptor agonists as novel ocular hypotensive agents and their cellular and molecular mechanisms of action. Sharif, N.A. Curr. Drug. Targets (2010) [Pubmed]
  3. Platelet-activating factor-induced intracellular signaling and release of cytokines and prostaglandin E2 in immortalized human corneal epithelial cells. Sharif, N.A., Wiernas, T.K. J. Ocul. Pharmacol. Ther (2010) [Pubmed]
  4. Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines. Sharif, N.A., Xu, S., Hellberg, P.E., Pang, I.H., Gamache, D.A., Yanni, J.M. Mol. Vis. (2009) [Pubmed]
  5. Cabergoline: Pharmacology, ocular hypotensive studies in multiple species, and aqueous humor dynamic modulation in the Cynomolgus monkey eyes. Sharif, N.A., McLaughlin, M.A., Kelly, C.R., Katoli, P., Drace, C., Husain, S., Crosson, C., Toris, C., Zhan, G.L., Camras, C. Exp. Eye Res. (2009) [Pubmed]
  6. Cat iris sphincter smooth-muscle contraction: comparison of FP-class prostaglandin analog agonist activities. Sharif, N.A., Kaddour-Djebbar, I., Abdel-Latif, A.A. J. Ocul. Pharmacol. Ther (2008) [Pubmed]
  7. Synthetic FP-prostaglandin-induced contraction of rat uterus smooth muscle in vitro. Sharif, N.A. Prostaglandins Leukot. Essent. Fatty Acids (2008) [Pubmed]
  8. AL-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. Sharif, N.A., McLaughlin, M.A., Kelly, C.R. J. Ocul. Pharmacol. Ther (2007) [Pubmed]
  9. Human trabecular meshwork cells express functional serotonin-2A (5HT2A) receptors: role in IOP reduction. Sharif, N.A., Kelly, C.R., McLaughlin, M. Invest. Ophthalmol. Vis. Sci. (2006) [Pubmed]
  10. Serotonin receptor subtype mRNA expression in human ocular tissues, determined by RT-PCR. Sharif, N.A., Senchyna, M. Mol. Vis. (2006) [Pubmed]
  11. Preclinical pharmacology of AL-12182, a new ocular hypotensive 11-oxa prostaglandin analog. Sharif, N.A., McLaughlin, M.A., Kelly, C.R., Xu, S., Crider, J.Y., Williams, G.W., Parker, J.L. J. Ocul. Pharmacol. Ther (2006) [Pubmed]
  12. Serotonin-2 (5-HT2) receptor-mediated signal transduction in human ciliary muscle cells: role in ocular hypotension. Sharif, N.A., Kelly, C.R., Crider, J.Y., Davis, T.L. J. Ocul. Pharmacol. Ther (2006) [Pubmed]
  13. Ocular hypotensive DP-class prostaglandin receptor affinities determined by quantitative autoradiography on human eye sections. Sharif, N.A., Davis, T.L., Williams, G.W. J. Ocul. Pharmacol. Ther (2005) [Pubmed]
  14. Pharmacological characterization and identification of EP3 prostanoid receptor binding sites in hamster uterus homogenates. Sharif, N.A., Xu, S.X. J. Pharm. Pharmacol. (2004) [Pubmed]
  15. Binding affinities of ocular hypotensive beta-blockers levobetaxolol, levobunolol, and timolol at endogenous guinea pig beta-adrenoceptors. Sharif, N.A., Xu, S.X. J. Ocul. Pharmacol. Ther (2004) [Pubmed]
  16. Cloned human 5-HT1A receptor pharmacology determined using agonist binding and measurement of cAMP accumulation. Sharif, N.A., Drace, C.D., Williams, G.W., Crider, J.Y. J. Pharm. Pharmacol. (2004) [Pubmed]
  17. Molecular pharmacology of the DP/EP2 class prostaglandin AL-6598 and quantitative autoradiographic visualization of DP and EP2 receptor sites in human eyes. Sharif, N.A., Williams, G.W., Crider, J.Y., Xu, S.X., Davis, T.L. J. Ocul. Pharmacol. Ther (2004) [Pubmed]
  18. Bimatoprost (Lumigan((R))) is an agonist at the cloned human ocular FP prostaglandin receptor: real-time FLIPR-based intracellular Ca(2+) mobilization studies. Sharif, N.A., Kelly, C.R., Williams, G.W. Prostaglandins Leukot. Essent. Fatty Acids (2003) [Pubmed]
  19. Ocular hypotensive FP prostaglandin (PG) analogs: PG receptor subtype binding affinities and selectivities, and agonist potencies at FP and other PG receptors in cultured cells. Sharif, N.A., Kelly, C.R., Crider, J.Y., Williams, G.W., Xu, S.X. J. Ocul. Pharmacol. Ther (2003) [Pubmed]
  20. Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. Sharif, N.A., Davis, T.L. J. Pharm. Pharmacol. (2002) [Pubmed]
  21. Pharmacological and molecular biological (RT-PCR) characterization of functional TP prostanoid receptors in immortalized human non-pigmented ciliary epithelial cells. Sharif, N.A., Senchyna, M., Xu, S.X. J. Ocul. Pharmacol. Ther (2002) [Pubmed]
  22. Agonist activity of bimatoprost, travoprost, latanoprost, unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor. Sharif, N.A., Kelly, C.R., Crider, J.Y. J. Ocul. Pharmacol. Ther (2002) [Pubmed]
  23. Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes. Sharif, N.A., Xu, S.X., Crider, J.Y., McLaughlin, M., Davis, T.L. J. Ocul. Pharmacol. Ther (2001) [Pubmed]
  24. Bimatoprost and its free acid are prostaglandin FP receptor agonists. Sharif, N.A., Williams, G.W., Kelly, C.R. Eur. J. Pharmacol. (2001) [Pubmed]
  25. Affinities, selectivities, potencies, and intrinsic activities of natural and synthetic prostanoids using endogenous receptors: focus on DP class prostanoids. Sharif, N.A., Crider, J.Y., Xu, S.X., Williams, G.W. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
  26. Pharmacology and autoradiography of human DP prostanoid receptors using [(3)H]-BWA868C, a DP receptor-selective antagonist radioligand. Sharif, N.A., Williams, G.W., Davis, T.L. Br. J. Pharmacol. (2000) [Pubmed]
  27. AL-3138 antagonizes FP prostanoid receptor-mediated inositol phosphates generation: comparison with some purported FP antagonists. Sharif, N.A., Crider, J.Y., Davis, T.L. J. Pharm. Pharmacol. (2000) [Pubmed]
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