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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Toshio Nishikimi

Department of Hypertension and Cardiorenal Medicine

Dokkyo Medical University

Mibu, Tochigi 321-0293



Name/email consistency: high



  • Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi 321-0293, Japan. 2001 - 2010
  • Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7525, USA. 2005
  • Research Institute, National Cardiovascular Center, Fujishirodai, Suita, Osaka. 2000 - 2001
  • Research Institute, Fujishirodai, Suita, Osaka 565, Japan. 2001


  1. Diversity of molecular forms of plasma brain natriuretic peptide in heart failure--different proBNP-108 to BNP-32 ratios in atrial and ventricular overload. Nishikimi, T., Minamino, N., Ikeda, M., Takeda, Y., Tadokoro, K., Shibasaki, I., Fukuda, H., Horiuchi, Y., Oikawa, S., Ieiri, T., Matsubara, M., Ishimitsu, T. Heart (2010) [Pubmed]
  2. Effects of long-term intravenous administration of adrenomedullin (AM) plus hANP therapy in acute decompensated heart failure: a pilot study. Nishikimi, T., Karasawa, T., Inaba, C., Ishimura, K., Tadokoro, K., Koshikawa, S., Yoshihara, F., Nagaya, N., Sakio, H., Kangawa, K., Matsuoka, H. Circ. J. (2009) [Pubmed]
  3. Stimulatory and Inhibitory regulation of lipolysis by the NPR-A/cGMP/PKG and NPR-C/G(i) pathways in rat cultured adipocytes. Nishikimi, T., Iemura-Inaba, C., Akimoto, K., Ishikawa, K., Koshikawa, S., Matsuoka, H. Regul. Pept. (2009) [Pubmed]
  4. Natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system has inhibitory effects in renal fibrosis in mice. Nishikimi, T., Inaba-Iemura, C., Ishimura, K., Tadokoro, K., Koshikawa, S., Ishikawa, K., Akimoto, K., Hattori, Y., Kasai, K., Minamino, N., Maeda, N., Matsuoka, H. Regul. Pept. (2009) [Pubmed]
  5. Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats. Nishikimi, T., Koshikawa, S., Ishikawa, Y., Akimoto, K., Inaba, C., Ishimura, K., Ono, H., Matsuoka, H. J. Hypertens. (2007) [Pubmed]
  6. Adrenomedullin in the kidney-renal physiological and pathophysiological roles. Nishikimi, T. Curr. Med. Chem. (2007) [Pubmed]
  7. The role of natriuretic peptides in cardioprotection. Nishikimi, T., Maeda, N., Matsuoka, H. Cardiovasc. Res. (2006) [Pubmed]
  8. Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effect of rho-kinase inhibitor in hypertensive glomerulosclerosis. Nishikimi, T., Matsuoka, H. J. Pharmacol. Sci. (2006) [Pubmed]
  9. Do increased plasma adrenomedullin levels in normotensive subjects precede hypertension?. Nishikimi, T. J. Hum. Hypertens (2006) [Pubmed]
  10. Chronic effect of combined treatment with omapatrilat and adrenomedullin on the progression of heart failure in rats. Nishikimi, T., Mori, Y., Ishimura, K., Ishikawa, Y., Koshikawa, S., Akimoto, K., Minamino, N., Kangawa, K., Matsuoka, H. Am. J. Hypertens. (2006) [Pubmed]
  11. Alteration of renal adrenomedullin and its receptor system in the severely hypertensive rat: effect of diuretic. Nishikimi, T., Wang, X., Akimoto, K., Tadokoro, K., Mori, Y., Ishikawa, Y., Ishimura, K., Yoshihara, F., Minamino, N., Kangawa, K., Matsuoka, H. Regul. Pept. (2005) [Pubmed]
  12. Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene. Nishikimi, T., Hagaman, J.R., Takahashi, N., Kim, H.S., Matsuoka, H., Smithies, O., Maeda, N. Cardiovasc. Res. (2005) [Pubmed]
  13. Response of adrenomedullin system to cytokine in cardiac fibroblasts-role of adrenomedullin as an antifibrotic factor. Nishikimi, T., Tadokoro, K., Akimoto, K., Mori, Y., Ishikawa, Y., Ishimura, K., Horio, T., Kangawa, K., Matsuoka, H. Cardiovasc. Res. (2005) [Pubmed]
  14. Cardiac adrenomedullin: its role in cardiac hypertrophy and heart failure. Nishikimi, T., Matsuoka, H. Curr. Med. Chem. Cardiovasc. Hematol. Agents (2005) [Pubmed]
  15. Association of plasma atrial natriuretic peptide, N-terminal proatrial natriuretic peptide, and brain natriuretic peptide levels with coronary artery stenosis in patients with normal left ventricular systolic function. Nishikimi, T., Mori, Y., Ishimura, K., Tadokoro, K., Yagi, H., Yabe, A., Horinaka, S., Matsuoka, H. Am. J. Med. (2004) [Pubmed]
  16. Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats. Nishikimi, T., Akimoto, K., Wang, X., Mori, Y., Tadokoro, K., Ishikawa, Y., Shimokawa, H., Ono, H., Matsuoka, H. J. Hypertens. (2004) [Pubmed]
  17. Ventricular adrenomedullin system in the transition from LVH to heart failure in rats. Nishikimi, T., Tadokoro, K., Mori, Y., Wang, X., Akimoto, K., Yoshihara, F., Minamino, N., Kangawa, K., Matsuoka, H. Hypertension (2003) [Pubmed]
  18. Cardioprotective effect of adrenomedullin in heart failure. Nishikimi, T., Yoshihara, F., Mori, Y., Kangawa, K., Matsuoka, H. Hypertens. Res. (2003) [Pubmed]
  19. Chronic administration of adrenomedullin attenuates transition from left ventricular hypertrophy to heart failure in rats. Nishikimi, T., Yoshihara, F., Horinaka, S., Kobayashi, N., Mori, Y., Tadokoro, K., Akimoto, K., Minamino, N., Kangawa, K., Matsuoka, H. Hypertension (2003) [Pubmed]
  20. Molecular forms of adrenomedullin in pericardial fluid and plasma in patients with ischaemic heart disease. Nishikimi, T., Shibasaki, I., Iida, H., Asakawa, H., Matsushita, Y., Mori, H., Mochizuki, Y., Okamura, Y., Horinaka, S., Kangawa, K., Shimada, K., Matsuoka, H. Clin. Sci. (2002) [Pubmed]
  21. Renoprotective effect of chronic adrenomedullin infusion in Dahl salt-sensitive rats. Nishikimi, T., Mori, Y., Kobayashi, N., Tadokoro, K., Wang, X., Akimoto, K., Yoshihara, F., Kangawa, K., Matsuoka, H. Hypertension (2002) [Pubmed]
  22. Cerivastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, inhibits cardiac myocyte hypertrophy induced by endothelin. Nishikimi, T., Tadokoro, K., Wang, X., Mori, Y., Asakawa, H., Akimoto, K., Yoshihara, F., Horio, T., Minamino, N., Matsuoka, H. Eur. J. Pharmacol. (2002) [Pubmed]
  23. The active molecular form of plasma adrenomedullin is extracted in the pulmonary circulation in patients with mitral stenosis: possible role of adrenomedullin in pulmonary hypertension. Nishikimi, T., Nagata, S., Sasaki, T., Yoshihara, F., Nagaya, N., Horio, T., Matsuo, H., Matsuoka, H., Kangawa, K. Clin. Sci. (2001) [Pubmed]
  24. Molecular forms of plasma and urinary adrenomedullin in normal, essential hypertension and chronic renal failure. Nishikimi, T., Horio, T., Kohmoto, Y., Yoshihara, F., Nagaya, N., Inenaga, T., Saito, M., Teranishi, M., Nakamura, M., Ohrui, M., Kawano, Y., Matsuo, H., Ishimitsu, T., Takishita, S., Matsuoka, H., Kangawa, K. J. Hypertens. (2001) [Pubmed]
  25. Plasma brain natriuretic peptide levels in chronic hemodialysis patients: influence of coronary artery disease. Nishikimi, T., Futoo, Y., Tamano, K., Takahashi, M., Suzuki, T., Minami, J., Honda, T., Uetake, S., Asakawa, H., Kobayashi, N., Horinaka, S., Ishimitsu, T., Matsuoka, H. Am. J. Kidney Dis. (2001) [Pubmed]
  26. Left ventricular mass relates to average systolic blood pressure, but not loss of circadian blood pressure in stable hemodialysis patients: an ambulatory 48-hour blood pressure study. Nishikimi, T., Minami, J., Tamano, K., Takahashi, M., Numabe, A., Futoo, Y., Honda, T., Kobayashi, T., Uetake, S., Mori, Y., Saito, T., Matsuoka, H. Hypertens. Res. (2001) [Pubmed]
  27. Role of increased circulating and renal adrenomedullin in rats with malignant hypertension. Nishikimi, T., Yoshihara, F., Kanazawa, A., Okano, I., Horio, T., Nagaya, N., Yutani, C., Matsuo, H., Matsuoka, H., Kangawa, K. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) [Pubmed]
  28. Production and clearance sites of two molecular forms of adrenomedullin in human plasma. Nishikimi, T., Matsuoka, H., Shimada, K., Matsuo, H., Kangawa, K. Am. J. Hypertens. (2000) [Pubmed]
  29. Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart. Nishikimi, T., Miyata, A., Horio, T., Yoshihara, F., Nagaya, N., Takishita, S., Yutani, C., Matsuo, H., Matsuoka, H., Kangawa, K. Am. J. Physiol. Heart Circ. Physiol. (2000) [Pubmed]
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