Arthur Gomtsyan
Global Pharmaceutical Research and Development
Neuroscience Research
Abbott Laboratories
Abbott Park
USA
Name/email consistency: high
- Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management. Gomtsyan, A., Bayburt, E.K., Schmidt, R.G., Surowy, C.S., Honore, P., Marsh, K.C., Hannick, S.M., McDonald, H.A., Wetter, J.M., Sullivan, J.P., Jarvis, M.F., Faltynek, C.R., Lee, C.H. J. Med. Chem. (2008)
- Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model. Gomtsyan, A., Bayburt, E.K., Keddy, R., Turner, S.C., Jinkerson, T.K., Didomenico, S., Perner, R.J., Koenig, J.R., Drizin, I., McDonald, H.A., Surowy, C.S., Honore, P., Mikusa, J., Marsh, K.C., Wetter, J.M., Faltynek, C.R., Lee, C.H. Bioorg. Med. Chem. Lett. (2007)
- Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties. Gomtsyan, A., Bayburt, E.K., Schmidt, R.G., Zheng, G.Z., Perner, R.J., Didomenico, S., Koenig, J.R., Turner, S., Jinkerson, T., Drizin, I., Hannick, S.M., Macri, B.S., McDonald, H.A., Honore, P., Wismer, C.T., Marsh, K.C., Wetter, J., Stewart, K.D., Oie, T., Jarvis, M.F., Surowy, C.S., Faltynek, C.R., Lee, C.H. J. Med. Chem. (2005)
- Nonnucleoside inhibitors of adenosine kinase. Gomtsyan, A., Lee, C.H. Curr. Pharm. Des. (2004)
- Synthesis and biological evaluation of pteridine and pyrazolopyrimidine based adenosine kinase inhibitors. Gomtsyan, A., Didomenico, S., Lee, C.H., Stewart, A.O., Bhagwat, S.S., Kowaluk, E.A., Jarvis, M.F. Bioorg. Med. Chem. Lett. (2004)
- Novel sequential process from N-methoxyamides and vinyl Grignard reagents: new synthesis of beta-aminoketones. Gomtsyan, A., Koenig, R.J., Lee, C.H. J. Org. Chem. (2001)
- Direct synthesis of beta-aminoketones from amides via novel sequential nucleophilic substitution/Michael reaction. Gomtsyan, A. Org. Lett. (2000)
