Mitsuteru Numazawa
Tohoku Pharmaceutical University
1-4 Komatsushima-4-chome
Sendai 981-8558
Japan
Name/email consistency: high
- Chemical aromatization of 19-hydroxyandrosta-1,4-diene-3,17-dione with acid or alkaline: elimination of the 19-hydroxymethyl group as formaldehyde. Numazawa, M., Yamashita, K., Kimura, N., Takahashi, M. Steroids (2009)
- Aromatization of androstenedione and 16alpha-hydroxyandrostenedione in human placental microsomes. Kinetic analysis of inhibition by the 19-oxygenated and 3-deoxy analogs. Numazawa, M., Watari, Y., Komatsu, S., Yamashita, K., Nagaoka, M. Steroids (2008)
- Mechanistic aspects of rearrangement of 16alpha-hydroxy-17-keto steroids to the 17beta-hydroxy-16-keto isomers. Numazawa, M., Nagaoka, M., Matsuzaki, H., Yamashita, K., Komatsu, S., Osawa, Y. Steroids (2008)
- Structure-activity relationships of estrogen derivatives as aromatase inhibitors. Effects of heterocyclic substituents. Numazawa, M., Komatsu, S., Tominaga, T., Yamashita, K. Chem. Pharm. Bull. (2008)
- Studies directed towards a mechanistic evaluation of inactivation of aromatase by the suicide substrates androsta-1,4-diene-3,17-diones and its 6-ene derivatives aromatase inactivation by the 19-substituted derivatives and their enzymic aromatization. Numazawa, M., Nagaoka, M., Handa, W., Ogawa, Y., Matsuoka, S. J. Steroid Biochem. Mol. Biol. (2007)
- Mass spectrometric analysis of oxygenations in aromatization of androst-4-ene-3,6,17-trione, a suicide substrate of aromatase, by placental microsomes. Isotope effect and stereochemistry. Numazawa, M., Takahashi, M., Nagaoka, M., Handa, W., Yamashita, K. J. Steroid Biochem. Mol. Biol. (2007)
- Inhibition of estrone sulfatase by aromatase inhibitor-based estrogen 3-sulfamates. Numazawa, M., Tominaga, T., Watari, Y., Tada, Y. Steroids (2006)
- Reduction of 1,4-dien-3-one steroids with LiAl2H4 or NaB2H4: stereospecific deuterium-labeling at the c-1alpha position of a 4-en-3-one steroid. Numazawa, M., Handa, W. Chem. Pharm. Bull. (2006)
- Gas chromatography-mass spectrometric study of 19-oxygenation of the aromatase inhibitor 19-methylandrostenedione with human placental microsomes. Numazawa, M., Nagaoka, M., Handa, W., Yamada, A. Biol. Pharm. Bull. (2006)
- Biochemical aromatization of 2-methyleneandrostenedione: stereochemistry of hydrogen removal at the C-1 position. Numazawa, M., Handa, W., Matsuzaki, H. J. Steroid Biochem. Mol. Biol. (2006)
- Structure-activity relationships of 2-, 4-, or 6-substituted estrogens as aromatase inhibitors. Numazawa, M., Ando, M., Watari, Y., Tominaga, T., Hayata, Y., Yoshimura, A. J. Steroid Biochem. Mol. Biol. (2005)
- Aromatase reaction of 3-deoxyandrogens: steric mode of the C-19 oxygenation and cleavage of the C10-C19 bond by human placental aromatase. Numazawa, M., Nagaoka, M., Sohtome, N. Biochemistry (2005)
- Structure-activity relationships of 2alpha-substituted androstenedione analogs as aromatase inhibitors and their aromatization reactions. Numazawa, M., Handa, W., Hasegawa, C., Takahashi, M. J. Steroid Biochem. Mol. Biol. (2005)
- Stereochemistry of NaBH4 reduction of a 19-carbonyl group of 3-deoxy androgens. Synthesis of [19S-3H]- and [19R-3H]-labeled aromatase inhibitors having a 19-hydroxy group. Numazawa, M., Sohtome, N., Nagaoka, M. Chem. Pharm. Bull. (2004)
- Synthesis and biochemical properties of 6-bromoandrostenedione derivatives with a 2,2-dimethyl or 2-methyl group as aromatase inhibitors. Numazawa, M., Handa, W., Yamada, K. Biol. Pharm. Bull. (2004)
- Kinetic analysis of reversible inhibition of 16alpha-hydroxyandrostenedione aromatization in human placental microsomes by suicide substrates of androstenedione aromatization. Numazawa, M., Mutsumi, A., Tachibana, M., Yoshimura, A. Biol. Pharm. Bull. (2003)
- Probing the active site of aromatase with 2-methyl-substituted androstenedione analogs. Numazawa, M., Watari, Y., Yamada, K., Umemura, N., Handa, W. Steroids (2003)
- Time-dependent aromatase inactivation by 4 beta,5 beta-epoxides of the natural substrate androstenedione and its 19-oxygenated analogs. Numazawa, M., Yoshimura, A., Tachibana, M., Shelangouski, M., Ishikawa, M. Steroids (2002)
- Improved synthesis and molecular modeling of 4beta,19-dihydroxyandrost-5-en-17-one, an excellent inhibitor of aromatase. Numazawa, M., Yamada, K., Watari, Y., Ando, M. Chem. Pharm. Bull. (2002)
- Aromatization of 16alpha-hydroxyandrostenedione by human placental microsomes: effect of preincubation with suicide substrates of androstenedione aromatization. Numazawa, M., Tachibana, M., Mutsumi, A., Yoshimura, A., Osawa, Y. J. Steroid Biochem. Mol. Biol. (2002)
- Studies on the catalytic function of aromatase: aromatization of 6-alkoxy-substituted androgens. Numazawa, M., Ando, M., Zennyoji, R. J. Steroid Biochem. Mol. Biol. (2002)
- Aromatase inhibition by 4 beta,5 beta-epoxides of 16 alpha-hydroxyandrostenedione and its 19-oxygenated analogs, potential precursors of estriol production in the feto-placental unit. Numazawa, M., Yoshimura, A., Watari, Y., Matsuzaki, H. Biol. Pharm. Bull. (2002)
- 19-Oxygenation of C19-steroids with an A, B-ring enone structure, competitive inhibitors of estrogen biosynthesis, with human placental aromatase. Numazawa, M., Yamada, K., Nagaoka, M. Biol. Pharm. Bull. (2001)
- Gas chromatography-mass spectrometric determination of activity of human placental aromatase using 16alpha-hydroxyandrostenedione as a substrate. Numazawa, M., Yoshimura, A., Nagaoka, M. Biol. Pharm. Bull. (2001)
- Identification of 16alpha,19-dihydroxyandrostenedione in the serum of pregnant women by gas chromatography-mass spectrometry. Numazawa, M., Satoh, S., Nagaoka, M., Honjo, H., Osawa, Y. Biol. Pharm. Bull. (2001)
- Production of 16beta-(acetoxy)acetoxy derivatives by reaction of 17-keto steroid enol acetates with lead (IV) acetate. Numazawa, M., Shelangouski, M., Nakakoshi, M. Steroids (2001)
- Role of hydrophilic interaction in binding of hydroxylated 3-deoxy C(19) steroids to the active site of aromatase. Numazawa, M., Yamada, K., Nitta, S., Sasaki, C., Kidokoro, K. J. Med. Chem. (2001)
- Synthesis and biochemical studies of 19-oxygenated derivatives of 6alpha- and 6beta-methylandrostenediones as catalytic probes for the active site of aromatase. Numazawa, M., Yoshimura, A. Biol. Pharm. Bull. (2000)
- Probing the binding pocket of the active site of aromatase with 6-ether or 6-ester substituted androst-4-ene-3,17-diones and their diene and triene analogs. Numazawa, M., Shelangouski, M., Nagasaka, M. Steroids (2000)
- Synthesis and structure-activity relationships of 6-phenylaliphatic-substituted C19 steroids having a 1,4-diene, 4,6-diene, or 1,4,6-triene structure as aromatase inhibitors. Numazawa, M., Yamaguchi, S. Steroids (1999)
- Synthesis of 19-oxygenated derivatives of the competitive inhibitor of aromatase, 5-androstene-4,17-dione. Numazawa, M., Yamada, K. Steroids (1999)
- Biological aromatization of delta4,6- and delta1,4,6-androgens and their 6-alkyl analogs, potent inhibitors of aromatase. Numazawa, M., Yoshimura, A. J. Steroid Biochem. Mol. Biol. (1999)
- 19-oxygenations of 3-deoxy androgens, potent competitive inhibitors of estrogen biosynthesis, with human placental aromatase. Numazawa, M., Nagaoka, M., Morio, M., Kamiyama, T. J. Steroid Biochem. Mol. Biol. (1999)