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R.S. Obach

Drug Metabolism Department

Candidate Synthesis

Enhancement

and Evaluation

USA

[email]@pfizer.com

Name/email consistency: high

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Affiliations

Drug Metabolism Department, Candidate Synthesis, Enhancement, and Evaluation, USA. 1999 - 2000
Department of Drug Metabolism, Pfizer Central Research, Groton, CT 06340, USA. 1997

References

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression. Obach, R.S. J. Pharmacol. Exp. Ther. (2000) [Pubmed]
Prediction of human clearance of twenty-nine drugs from hepatic microsomal intrinsic clearance data: An examination of in vitro half-life approach and nonspecific binding to microsomes. Obach, R.S. Drug Metab. Dispos. (1999) [Pubmed]
Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol. Obach, R.S. Drug Metab. Dispos. (1997) [Pubmed]