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Yutaro Obara

Department of Cellular Signaling

Graduate School of Pharmaceutical Sciences

Tohoku University

Aoba, Aramaki

Japan

[email]@*.*.tohoku.ac.jp

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Affiliation

Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Japan. 2005 - 2011

References

Basic fibroblast growth factor promotes glial cell-derived neurotrophic factor gene expression mediated by activation of ERK5 in rat C6 glioma cells. Obara, Y., Nemoto, W., Kohno, S., Murata, T., Kaneda, N., Nakahata, N. Cell. Signal. (2011) [Pubmed]
The signaling pathway leading to extracellular signal-regulated kinase 5 (ERK5) activation via G-proteins and ERK5-dependent neurotrophic effects. Obara, Y., Nakahata, N. Mol. Pharmacol. (2010) [Pubmed]
ERK5 activity is required for nerve growth factor-induced neurite outgrowth and stabilization of tyrosine hydroxylase in PC12 cells. Obara, Y., Yamauchi, A., Takehara, S., Nemoto, W., Takahashi, M., Stork, P.J., Nakahata, N. J. Biol. Chem. (2009) [Pubmed]
Betagamma subunits of G(i/o) suppress EGF-induced ERK5 phosphorylation, whereas ERK1/2 phosphorylation is enhanced. Obara, Y., Okano, Y., Ono, S., Yamauchi, A., Hoshino, T., Kurose, H., Nakahata, N. Cell. Signal. (2008) [Pubmed]
5,19-cyclo-9beta,10xi-androstane-3,17-dione promotes neurotrophic factor biosynthesis in 1321N1 human astrocytoma cells and improves passive avoidance learning impairment. Obara, Y., Haganuma, A., Murakami, S., Chiba, T., Mori, K., Nakagawasai, O., Tadano, T., Kikuchi, H., Oshima, Y., Nakahata, N. Brain Res. (2007) [Pubmed]
A novel cyathane diterpene, cyrneine A, induces neurite outgrowth in a Rac1-dependent mechanism in PC12 cells. Obara, Y., Hoshino, T., Marcotullio, M.C., Pagiotti, R., Nakahata, N. Life Sci. (2007) [Pubmed]
Thromboxane A2 promotes interleukin-6 biosynthesis mediated by an activation of cyclic AMP-response element-binding protein in 1321N1 human astrocytoma cells. Obara, Y., Kurose, H., Nakahata, N. Mol. Pharmacol. (2005) [Pubmed]