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Leo A. Paquette

Evans Chemical Laboratories

The Ohio State University

Columbus

Ohio 43210-1185

USA

[email]@osu.edu

Name/email consistency: high

 
 
 
 
 
 
 

Affiliation

  • Evans Chemical Laboratories, The Ohio State University, Columbus, Ohio 43210-1185, USA. 2000 - 2009

References

  1. Contrasting responses of pyrido[2,1-a]isoindol-6-ones and their sultam counterparts to photochemical activation. Paquette, L.A., Dura, R.D., Modolo, I. J. Org. Chem. (2009) [Pubmed]
  2. Pestalotiopsin A. Side chain installation and exhaustive probing of olefin metathesis as a possible tool for elaborating the cyclononene ring. Paquette, L.A., Dong, S., Parker, G.D. J. Org. Chem. (2007) [Pubmed]
  3. Pestalotiopsin a. Enantioselective construction of potential building blocks derived from antipodal cyclobutanol intermediates. Paquette, L.A., Parker, G.D., Tei, T., Dong, S. J. Org. Chem. (2007) [Pubmed]
  4. Studies toward the total synthesis of dumsin. 2. A second generation approach resulting in enantioselective construction of a functionalized ABC subunit of the tetranortriterpenoid insect antifeedant. Paquette, L.A., Hu, Y., Luxenburger, A., Bishop, R.L. J. Org. Chem. (2007) [Pubmed]
  5. Asymmetric synthesis of the phytopathogen (+)-fomannosin. Paquette, L.A., Peng, X., Yang, J. Angew. Chem. Int. Ed. Engl. (2007) [Pubmed]
  6. Practical designed syntheses of all stereoisomeric bis(2,2')- and tris(2,2',2' ')-tetrahydrofurans. Paquette, L.A., Hilmey, D.G., Gallucci, J.C. Org. Lett. (2006) [Pubmed]
  7. From common carbohydrates to enantiopure cyclooctane polyols and glycomimetics via deoxygenative zirconocene ring contraction. Paquette, L.A., Zhang, Y. J. Org. Chem. (2006) [Pubmed]
  8. Exploratory studies aimed at a synthesis of vinigrol. 2. Attempts to exploit ring-closing metathesis for construction of the central cyclooctane belt. Paquette, L.A., Efremov, I., Liu, Z. J. Org. Chem. (2005) [Pubmed]
  9. Exploratory studies aimed at a synthesis of vinigrol. 3. Evaluation of a lactone bridge as a conformational lock. Paquette, L.A., Efremov, I. J. Org. Chem. (2005) [Pubmed]
  10. Exploratory studies aimed at a synthesis of vinigrol. 4. Probe of possible means for direct connection of the side arms and of ring-contraction alternatives. Paquette, L.A., Liu, Z., Efremov, I. J. Org. Chem. (2005) [Pubmed]
  11. Enantioselective route from carbohydrates to cyclooctane polyols. Paquette, L.A., Zhang, Y. Org. Lett. (2005) [Pubmed]
  12. The polyol domain of amphidinol 3. A stereoselective synthesis of the entire C(1)-C(30) sector. Paquette, L.A., Chang, S.K. Org. Lett. (2005) [Pubmed]
  13. Stereoselective synthesis of beta-anomeric 4'-thiaspirocyclic ribonucleosides carrying the full complement of RNA-level hydroxyl substitution. Paquette, L.A., Dong, S. J. Org. Chem. (2005) [Pubmed]
  14. Competitive stereochemical control operative during conrotatory electrocyclization of helically equilibrating diquinanyl-substituted 1,3,5,7-octatetraenyl bisenolates. Paquette, L.A., Liu, Z., Ramsey, C., Gallucci, J.C. J. Org. Chem. (2005) [Pubmed]
  15. Reactions of alpha,alpha'-dihydroxy ketones with phosgene. Structural requirements for spiro epoxy carbonate formation. Paquette, L.A., Hartung, R.E., Hofferberth, J.E., Gallucci, J.C. Org. Lett. (2004) [Pubmed]
  16. Synthesis of stereoisomeric medium-ring alpha,alpha'-dihydroxy cycloalkanones. Paquette, L.A., Hartung, R.E., Hofferberth, J.E., Vilotijevic, I., Yang, J. J. Org. Chem. (2004) [Pubmed]
  17. Synthesis of 1-Aza-8-thiabicyclo[4.2.1]nona-2,4-diene 8,8-dioxide and its conversion to a strained spirocycle via photoinduced SO2-N bond cleavage. Paquette, L.A., Barton, W.R., Gallucci, J.C. Org. Lett. (2004) [Pubmed]
  18. Conformationally constrained purine mimics. Incorporation of adenine and guanine into spirocyclic nucleosides. Paquette, L.A., Kahane, A.L., Seekamp, C.K. J. Org. Chem. (2004) [Pubmed]
  19. Synthetic studies aimed at (-)-cochleamycin A. Evaluation of late-stage macrocyclization alternatives. Paquette, L.A., Chang, J., Liu, Z. J. Org. Chem. (2004) [Pubmed]
  20. Stereochemical features of Lewis acid-promoted glycosidations involving 4'-spiroannulated DNA building blocks. Paquette, L.A., Seekamp, C.K., Kahane, A.L., Hilmey, D.G., Gallucci, J. J. Org. Chem. (2004) [Pubmed]
  21. Contrasting diastereofacial selectivity associated with N-phenyltriazolinedione cycloadditions to oxaspirocycloheptatrienes. Paquette, L.A., Webber, P., Simpson, I. Org. Lett. (2003) [Pubmed]
  22. Zirconocene-mediated route to enantiopure 9-oxabicyclononanes functionalized on both carbon bridges. Paquette, L.A., Kim, I.H., Cunière, N. Org. Lett. (2003) [Pubmed]
  23. Divergent regioselectivity in the base-promoted reactions of cyclic eight-membered alpha-ketols with activated halides. Paquette, L.A., Vilotijevic, I., Hilmey, D., Yang, J. Org. Lett. (2003) [Pubmed]
  24. Conversion of the enantiomers of spiro[4.4]nonane-1,6-diol into both epimeric carbaspironucleosides having natural C1' absolute configuration. Paquette, L.A., Hartung, R.E., France, D.J. Org. Lett. (2003) [Pubmed]
  25. Effect of 9,10-cyclic acetal stereochemistry on feasible operation of the alpha-ketol rearrangement in highly functionalized paclitaxel (Taxol) precursors. Paquette, L.A., Hofferberth, J.E. J. Org. Chem. (2003) [Pubmed]
  26. A delicate balance of energetics. Subtleties associated with alpha-ketol-based bridge migration to afford 9-keto-10beta-p-methoxybenzyloxytaxanes. Paquette, L.A., Lo, H.Y., Hofferberth, J.E., Gallucci, J.C. J. Org. Chem. (2003) [Pubmed]
  27. Chemical modification of a highly functionalized taxane. The consequences of an absent bridgehead double bond on oxetane D-ring construction. Paquette, L.A., Lo, H.Y. J. Org. Chem. (2003) [Pubmed]
  28. pi-Facial stereoselectivity in Diels-Alder cycloadditions to 1-oxaspiro[4.5]deca-6,9-dien-8-one. The strong directive effect of ether oxygen in a cross-conjugated ketone setting. Paquette, L.A., Shetuni, B.B., Gallucci, J.C. Org. Lett. (2003) [Pubmed]
  29. Convergent enantioselective synthesis of vinigrol, an architecturally novel diterpenoid with potent platelet aggregation inhibitory and antihypertensive properties. 1. Application of anionic sigmatropy to construction of the octalin substructure. Paquette, L.A., Guevel, R., Sakamoto, S., Kim, I.H., Crawford, J. J. Org. Chem. (2003) [Pubmed]
  30. Total synthesis of dumsin. 1. Retrosynthetic strategy and the elaboration of key intermediates from (--)-bornyl acetate. Paquette, L.A., Hong, F.T. J. Org. Chem. (2003) [Pubmed]
  31. Conformational restriction of nucleosides by spirocyclic annulation at C4' including synthesis of the complementary dideoxy and didehydrodideoxy analogues. Paquette, L.A., Seekamp, C.K., Kahane, A.L. J. Org. Chem. (2003) [Pubmed]
  32. C4'-spiroalkylated nucleosides having sulfur incorporated at the apex position. Paquette, L.A., Fabris, F., Gallou, F., Dong, S. J. Org. Chem. (2003) [Pubmed]
  33. Pectenotoxin-2 synthetic studies. 1. Alkoxide precoordination to [Rh(NBD)(DIPHOS-4)]BF(4) allows directed hydrogenation of a 2,3-dihydrofuran-3-ol without competing furan production. Paquette, L.A., Peng, X., Bondar, D. Org. Lett. (2002) [Pubmed]
  34. Diastereoselectivity control in the zirconocene-mediated ring contraction of 4-vinylfuranosides to enantiopure multiply functionalized cyclobutanes. Paquette, L.A., Cunière, N. Org. Lett. (2002) [Pubmed]
  35. Concerning the antileukemic agent jatrophatrione: the first total synthesis of a [5.9.5] tricyclic diterpene. Paquette, L.A., Yang, J., Long, Y.O. J. Am. Chem. Soc. (2002) [Pubmed]
  36. Applications of the squarate ester cascade to the expeditious synthesis of hypnophilin, coriolin, and ceratopicanol. Paquette, L.A., Geng, F. J. Am. Chem. Soc. (2002) [Pubmed]
  37. A highly abbreviated synthesis of pentalenene by means of the squarate ester cascade. Paquette, L.A., Geng, F. Org. Lett. (2002) [Pubmed]
  38. 1-Oxaspiro[4.4]nonan-6-ones. Synthetic access via oxonium ion technology, optical resolution, and conversion into enantiopure spirocyclic alpha,beta-butenolides. Paquette, L.A., Owen, D.R., Bibart, R.T., Seekamp, C.K., Kahane, A.L., Lanter, J.C., Corral, M.A. J. Org. Chem. (2001) [Pubmed]
  39. Constraining of small-ring cyclic ether triads by stereodefined spiroannulation to an inositol orthoformate platform. Solution- and gas-phase alkali metal binding affinities for three- to five-membered ring structural combinations. Paquette, L.A., Ra, C.S., Gallucci, J.C., Kang, H.J., Ohmori, N., Arrington, M.P., David, W., Brodbelt, J.S. J. Org. Chem. (2001) [Pubmed]
  40. Spirocyclic restriction of nucleosides. Synthesis of the first exemplary syn-1-oxaspiro[4.4]nonanyl member. Paquette, L.A., Bibart, R.T., Seekamp, C.K., Kahane, A.L. Org. Lett. (2001) [Pubmed]
  41. Spirocyclic restriction of nucleosides. An analysis of protecting group feasibility while accessing prototype anti-1-oxaspiro[4.4]nonanyl mimics. Paquette, L.A., Owen, D.R., Bibart, R.T., Seekamp, C.K. Org. Lett. (2001) [Pubmed]
  42. The sclerophytin A adventure. Paquette, L.A. Chem. Rec (2001) [Pubmed]
  43. A convenient method for removing all highly-colored byproducts generated during olefin metathesis reactions. Paquette, L.A., Schloss, J.D., Efremov, I., Fabris, F., Gallou, F., Mendez-Andino, J., Yang, J. Org. Lett. (2000) [Pubmed]
  44. Synthesis and crystal structure of a unique linear homoditopic ligand bifacially complexed to lithium picrate. Paquette, L.A., Tae, J., Gallucci, J.C. Org. Lett. (2000) [Pubmed]
  45. Vicinal tetrahydrofuranyl substitution of alkyl chains. Tetra-, penta-, and hexafunctionalized arrays. Paquette, L.A., Ohmori, N., Lowinger, T.B., Rogers, R.D. J. Org. Chem. (2000) [Pubmed]
  46. Synthesis of the alleged structure of sclerophytin A. The setting of two oxygen bridges within the fused cyclodecanol B ring is not Nature's Way. Paquette, L.A., Moradei, O.M., Bernardelli, P., Lange, T. Org. Lett. (2000) [Pubmed]
 
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