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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Paul J. Fletcher

Section of Biopsychology

Centre for Addiction and Mental Health





Name/email consistency: high



  • Section of Biopsychology, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. 2002 - 2010
  • Department of Psychiatry, University of Toronto, Toronto, Canada. 2002


  1. Genetic and pharmacological evidence that 5-HT2C receptor activation, but not inhibition, affects motivation to feed under a progressive ratio schedule of reinforcement. Fletcher, P.J., Sinyard, J., Higgins, G.A. Pharmacol. Biochem. Behav. (2010) [Pubmed]
  2. Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice. Fletcher, P.J., Tampakeras, M., Sinyard, J., Slassi, A., Isaac, M., Higgins, G.A. Neuropharmacology (2009) [Pubmed]
  3. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Fletcher, P.J., Rizos, Z., Sinyard, J., Tampakeras, M., Higgins, G.A. Neuropsychopharmacology (2008) [Pubmed]
  4. Serotonin receptors as potential targets for modulation of nicotine use and dependence. Fletcher, P.J., Lê, A.D., Higgins, G.A. Prog. Brain Res. (2008) [Pubmed]
  5. A sensitizing regimen of amphetamine impairs visual attention in the 5-choice serial reaction time test: reversal by a D1 receptor agonist injected into the medial prefrontal cortex. Fletcher, P.J., Tenn, C.C., Sinyard, J., Rizos, Z., Kapur, S. Neuropsychopharmacology (2007) [Pubmed]
  6. Opposing effects of 5-HT(2A) and 5-HT(2C) receptor antagonists in the rat and mouse on premature responding in the five-choice serial reaction time test. Fletcher, P.J., Tampakeras, M., Sinyard, J., Higgins, G.A. Psychopharmacology (Berl.) (2007) [Pubmed]
  7. The effects of the 5-HT(2C) receptor antagonist SB242084 on locomotor activity induced by selective, or mixed, indirect serotonergic and dopaminergic agonists. Fletcher, P.J., Sinyard, J., Higgins, G.A. Psychopharmacology (Berl.) (2006) [Pubmed]
  8. Injection of the 5-HT2C receptor agonist Ro60-0175 into the ventral tegmental area reduces cocaine-induced locomotor activity and cocaine self-administration. Fletcher, P.J., Chintoh, A.F., Sinyard, J., Higgins, G.A. Neuropsychopharmacology (2004) [Pubmed]
  9. Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effects. Fletcher, P.J., Sinyard, J., Salsali, M., Baker, G.B. Psychopharmacology (Berl.) (2004) [Pubmed]
  10. Activation of 5-HT(1B) receptors in the nucleus accumbens reduces self-administration of amphetamine on a progressive ratio schedule. Fletcher, P.J., Azampanah, A., Korth, K.M. Pharmacol. Biochem. Behav. (2002) [Pubmed]
  11. Multiple 5-HT receptors are involved in the effects of acute MDMA treatment: studies on locomotor activity and responding for conditioned reinforcement. Fletcher, P.J., Korth, K.M., Robinson, S.R., Baker, G.B. Psychopharmacology (Berl.) (2002) [Pubmed]
  12. Differential effects of the 5-HT(2A) receptor antagonist M100907 and the 5-HT(2C) receptor antagonist SB242084 on cocaine-induced locomotor activity, cocaine self-administration and cocaine-induced reinstatement of responding. Fletcher, P.J., Grottick, A.J., Higgins, G.A. Neuropsychopharmacology (2002) [Pubmed]
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