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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Philip Seeman

Departments of Pharmacology and Psychiatry

University of Toronto

260 Heath Street West

Suite 605



Name/email consistency: high



  • Departments of Pharmacology and Psychiatry, University of Toronto, 260 Heath Street West, Suite 605, Canada. 2003 - 2012
  • Pharmacology and Psychiatry Departments, University of Toronto, Toronto, Ontario, Canada. 2012
  • Department of Pharmacology, University of Toronto, Toronto, Canada M5P 3L6. 1997 - 2012
  • University of Toronto, Pharmacology Department, Faculty of Medicine, Medical Science Building, Canada. 2006


  1. Comment on: "Effects of a novel mGlu(2/3) receptor agonist prodrug, LY2140023 monohydrate, on central monoamine turnover as determined in human and rat cerebrospinal fluid" (Lowe S, Dean R, Ackermann B, Jackson K, Natanegara F, Anderson S, Eckstein J, Yuen E, Ayan-Oshodi M, Ho M, McKinzie D, Perry K, Svensson K, Psychopharmacology, 2012). Seeman, P. Psychopharmacology (Berl.) (2012) [Pubmed]
  2. Comment on "A Multicenter, Inpatient, Phase 2, Double-Blind, Placebo-Controlled Dose-Ranging Study of LY2140023 Monohydrate in Patients With DSM-IV Schizophrenia" by Kinon et al. Seeman, P. J. Clin. Psychopharmacol (2012) [Pubmed]
  3. Dopamine agonist radioligand binds to both D2High and D2Low receptors, explaining why alterations in D2High are not detected in human brain scans. Seeman, P. Synapse (2012) [Pubmed]
  4. All roads to schizophrenia lead to dopamine supersensitivity and elevated dopamine D2(high) receptors. Seeman, P. CNS. Neurosci. Ther (2011) [Pubmed]
  5. Alzheimer's disease: β-amyloid plaque formation in human brain. Seeman, P., Seeman, N. Synapse (2011) [Pubmed]
  6. Dopamine D2 receptors as treatment targets in schizophrenia. Seeman, P. Clin. Schizophr. Relat. Psychoses (2010) [Pubmed]
  7. Glutamate receptor mGlu2 and mGlu3 knockout striata are dopamine supersensitive, with elevated D2(High) receptors and marked supersensitivity to the dopamine agonist (+)PHNO. Seeman, P., Battaglia, G., Corti, C., Corsi, M., Bruno, V. Synapse (2009) [Pubmed]
  8. Glutamate and dopamine components in schizophrenia. Seeman, P. J. Psychiatry. Neurosci (2009) [Pubmed]
  9. Dopamine D2High receptors stimulated by phencyclidines, lysergic acid diethylamide, salvinorin A, and modafinil. Seeman, P., Guan, H.C., Hirbec, H. Synapse (2009) [Pubmed]
  10. Glutamate agonists for treating schizophrenia have affinity for dopamine D2High and D3 receptors. Seeman, P., Guan, H.C. Synapse (2009) [Pubmed]
  11. Glutamate agonist LY404,039 for treating schizophrenia has affinity for the dopamine D2(High) receptor. Seeman, P., Guan, H.C. Synapse (2009) [Pubmed]
  12. Dopamine D2(High) receptors on intact cells. Seeman, P. Synapse (2008) [Pubmed]
  13. Dopamine partial agonist actions of the glutamate receptor agonists LY 354,740 and LY 379,268. Seeman, P., Caruso, C., Lasaga, M. Synapse (2008) [Pubmed]
  14. Memantine agonist action at dopamine D2High receptors. Seeman, P., Caruso, C., Lasaga, M. Synapse (2008) [Pubmed]
  15. Dopamine D2(High) receptors moderately elevated by sertindole. Seeman, P. Synapse (2008) [Pubmed]
  16. Phencyclidine and glutamate agonist LY379268 stimulate dopamine D2High receptors: D2 basis for schizophrenia. Seeman, P., Guan, H.C. Synapse (2008) [Pubmed]
  17. Dopamine D2(High) receptors moderately elevated by bifeprunox and aripiprazole. Seeman, P. Synapse (2008) [Pubmed]
  18. Antiparkinson therapeutic potencies correlate with their affinities at dopamine D2(High) receptors. Seeman, P. Synapse (2007) [Pubmed]
  19. Increased dopamine D2(High) receptors in amphetamine-sensitized rats, measured by the agonist [(3)H](+)PHNO. Seeman, P., McCormick, P.N., Kapur, S. Synapse (2007) [Pubmed]
  20. Consistent with dopamine supersensitivity, RGS9 expression is diminished in the amphetamine-treated animal model of schizophrenia and in postmortem schizophrenia brain. Seeman, P., Ko, F., Jack, E., Greenstein, R., Dean, B. Synapse (2007) [Pubmed]
  21. Dopamine partial agonist action of (-)OSU6162 is consistent with dopamine hyperactivity in psychosis. Seeman, P., Guan, H.C. Eur. J. Pharmacol. (2007) [Pubmed]
  22. Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus. Seeman, P., Wilson, A., Gmeiner, P., Kapur, S. Synapse (2006) [Pubmed]
  23. Psychosis pathways converge via D2high dopamine receptors. Seeman, P., Schwarz, J., Chen, J.F., Szechtman, H., Perreault, M., McKnight, G.S., Roder, J.C., Quirion, R., Boksa, P., Srivastava, L.K., Yanai, K., Weinshenker, D., Sumiyoshi, T. Synapse (2006) [Pubmed]
  24. Targeting the dopamine D2 receptor in schizophrenia. Seeman, P. Expert Opin. Ther. Targets (2006) [Pubmed]
  25. Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis. Seeman, P., Weinshenker, D., Quirion, R., Srivastava, L.K., Bhardwaj, S.K., Grandy, D.K., Premont, R.T., Sotnikova, T.D., Boksa, P., El-Ghundi, M., O'dowd, B.F., George, S.R., Perreault, M.L., Männistö, P.T., Robinson, S., Palmiter, R.D., Tallerico, T. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  26. Dopamine receptor contribution to the action of PCP, LSD and ketamine psychotomimetics. Seeman, P., Ko, F., Tallerico, T. Mol. Psychiatry (2005) [Pubmed]
  27. Dopamine agonist action of phencyclidine. Seeman, P., Lasaga, M. Synapse (2005) [Pubmed]
  28. Alcohol-withdrawn animals have a prolonged increase in dopamine D2high receptors, reversed by general anesthesia: relation to relapse?. Seeman, P., Tallerico, T., Ko, F. Synapse (2004) [Pubmed]
  29. Comment on "Diverse psychotomimetics act through a common signaling pathway". Seeman, P. Science (2004) [Pubmed]
  30. Link between dopamine D1 and D2 receptors in rat and human striatal tissues. Seeman, P., Tallerico, T. Synapse (2003) [Pubmed]
  31. Dopamine displaces [3H]domperidone from high-affinity sites of the dopamine D2 receptor, but not [3H]raclopride or [3H]spiperone in isotonic medium: Implications for human positron emission tomography. Seeman, P., Tallerico, T., Ko, F. Synapse (2003) [Pubmed]
  32. Anesthetics inhibit high-affinity states of dopamine D2 and other G-linked receptors. Seeman, P., Kapur, S. Synapse (2003) [Pubmed]
  33. Methylphenidate elevates resting dopamine which lowers the impulse-triggered release of dopamine: a hypothesis. Seeman, P., Madras, B. Behav. Brain Res. (2002) [Pubmed]
  34. Atypical antipsychotics: mechanism of action. Seeman, P. Can. J. Psychiatry (2002) [Pubmed]
  35. Amphetamine-sensitized animals show a marked increase in dopamine D2 high receptors occupied by endogenous dopamine, even in the absence of acute challenges. Seeman, P., Tallerico, T., Ko, F., Tenn, C., Kapur, S. Synapse (2002) [Pubmed]
  36. Schizophrenia: more dopamine, more D2 receptors. Seeman, P., Kapur, S. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  37. Rapid release of antipsychotic drugs from dopamine D2 receptors: an explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine. Seeman, P., Tallerico, T. Am. J. Psychiatry (1999) [Pubmed]
  38. Role of dopamine D2, D4 and serotonin(2A) receptors in antipsychotic and anticataleptic action. Seeman, P., Tallerico, T., Corbett, R., Van Tol, H.H., Kamboj, R.K. J. Psychopharmacol. (Oxford) (1997) [Pubmed]
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