Paul A. Lapchak
Department of Neuroscience
University of California San Diego
9500 Gilman Drive
La Jolla
USA
Name/email consistency: high
- Efficacy and safety profile of the carotenoid trans sodium crocetinate administered to rabbits following multiple infarct ischemic strokes: a combination therapy study with tissue plasminogen activator. Lapchak, P.A. Brain Res. (2010)
- Transcranial near infrared laser treatment (NILT) increases cortical adenosine-5'-triphosphate (ATP) content following embolic strokes in rabbits. Lapchak, P.A., De Taboada, L. Brain Res. (2010)
- The lipophilic multifunctional antioxidant edaravone (radicut) improves behavior following embolic strokes in rabbits: a combination therapy study with tissue plasminogen activator. Lapchak, P.A., Zivin, J.A. Exp. Neurol. (2009)
- The 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin reduces thrombolytic-induced intracerebral hemorrhage in embolized rabbits. Lapchak, P.A., Han, M.K. Brain Res. (2009)
- Effect of internal carotid artery reperfusion in combination with Tenecteplase on clinical scores and hemorrhage in a rabbit embolic stroke model. Lapchak, P.A. Brain Res. (2009)
- Carbamylated erythropoietin to treat neuronal injury: new development strategies. Lapchak, P.A. Expert. Opin. Investig. Drugs (2008)
- Safety profile of transcranial near-infrared laser therapy administered in combination with thrombolytic therapy to embolized rabbits. Lapchak, P.A., Han, M.K., Salgado, K.F., Streeter, J., Zivin, J.A. Stroke (2008)
- Therapeutic window for nonerythropoietic carbamylated-erythropoietin to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits. Lapchak, P.A., Kirkeby, A., Zivin, J.A., Sager, T.N. Brain Res. (2008)
- Advances in hemorrhagic stroke therapy: conventional and novel approaches. Lapchak, P.A., Araujo, D.M. Expert. Opin. Emerg. Drugs (2007)
- The phenylpropanoid micronutrient chlorogenic acid improves clinical rating scores in rabbits following multiple infarct ischemic strokes: synergism with tissue plasminogen activator. Lapchak, P.A. Exp. Neurol. (2007)
- Tumor necrosis factor-alpha is involved in thrombolytic-induced hemorrhage following embolic strokes in rabbits. Lapchak, P.A. Brain Res. (2007)
- Baicalein, an antioxidant 12/15-lipoxygenase inhibitor improves clinical rating scores following multiple infarct embolic strokes. Lapchak, P.A., Maher, P., Schubert, D., Zivin, J.A. Neuroscience (2007)
- Transcranial near-infrared light therapy improves motor function following embolic strokes in rabbits: an extended therapeutic window study using continuous and pulse frequency delivery modes. Lapchak, P.A., Salgado, K.F., Chao, C.H., Zivin, J.A. Neuroscience (2007)
- Advances in ischemic stroke treatment: neuroprotective and combination therapies. Lapchak, P.A., Araujo, D.M. Expert. Opin. Emerg. Drugs (2007)
- 3alpha-OL-5-beta-pregnan-20-one hemisuccinate, a steroidal low-affinity NMDA receptor antagonist improves clinical rating scores in a rabbit multiple infarct ischemia model: synergism with tissue plasminogen activator. Lapchak, P.A. Exp. Neurol. (2006)
- Memantine, an uncompetitive low affinity NMDA open-channel antagonist improves clinical rating scores in a multiple infarct embolic stroke model in rabbits. Lapchak, P.A. Brain Res. (2006)
- Comparison of Tenecteplase with Alteplase on clinical rating scores following small clot embolic strokes in rabbits. Lapchak, P.A., Araujo, D.M., Zivin, J.A. Exp. Neurol. (2004)
- The neuroactive steroid 3-alpha-ol-5-beta-pregnan-20-one hemisuccinate, a selective NMDA receptor antagonist improves behavioral performance following spinal cord ischemia. Lapchak, P.A. Brain Res. (2004)
- Transcranial infrared laser therapy improves clinical rating scores after embolic strokes in rabbits. Lapchak, P.A., Wei, J., Zivin, J.A. Stroke (2004)
- Coadministration of NXY-059 and tenecteplase six hours following embolic strokes in rabbits improves clinical rating scores. Lapchak, P.A., Song, D., Wei, J., Zivin, J.A. Exp. Neurol. (2004)
- Pharmacology of caffeinol in embolized rabbits: clinical rating scores and intracerebral hemorrhage incidence. Lapchak, P.A., Song, D., Wei, J., Zivin, J.A. Exp. Neurol. (2004)
- Effects of intrathecal administration of a cell permeant caspase inhibitor, boc-D-fluoromethylketone (BDFMK), on behavioral deficits following spinal cord ischemia: a dose-response analysis. Lapchak, P.A., Araujo, D.M., Weir, C.J., Wei, J., Zivin, J.A. Brain Res. (2003)
- Ebselen, a seleno-organic antioxidant, is neuroprotective after embolic strokes in rabbits: synergism with low-dose tissue plasminogen activator. Lapchak, P.A., Zivin, J.A. Stroke (2003)
- Development of the nitrone-based spin trap agent NXY-059 to treat acute ischemic stroke. Lapchak, P.A., Araujo, D.M. CNS. Drug. Rev (2003)
- Therapeutic potential of platelet glycoprotein IIb/IIIa receptor antagonists in the management of ischemic stroke. Lapchak, P.A., Araujo, D.M. Am. J. Cardiovasc. Drugs (2003)
- The nonpeptide glycoprotein IIb/IIIa platelet receptor antagonist SM-20302 reduces tissue plasminogen activator-induced intracerebral hemorrhage after thromboembolic stroke. Lapchak, P.A., Araujo, D.M., Song, D., Zivin, J.A. Stroke (2002)
- Hemorrhagic transformation following ischemic stroke: significance, causes, and relationship to therapy and treatment. Lapchak, P.A. Curr. Neurol. Neurosci. Rep (2002)
- Neuroprotective effects of the spin trap agent disodium-[(tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) in a rabbit small clot embolic stroke model: combination studies with the thrombolytic tissue plasminogen activator. Lapchak, P.A., Araujo, D.M., Song, D., Wei, J., Zivin, J.A. Stroke (2002)
- Effects of the spin trap agent disodium- [tert-butylimino)methyl]benzene-1,3-disulfonate N-oxide (generic NXY-059) on intracerebral hemorrhage in a rabbit Large clot embolic stroke model: combination studies with tissue plasminogen activator. Lapchak, P.A., Araujo, D.M., Song, D., Wei, J., Purdy, R., Zivin, J.A. Stroke (2002)
- Microplasmin: a novel thrombolytic that improves behavioral outcome after embolic strokes in rabbits. Lapchak, P.A., Araujo, D.M., Pakola, S., Song, D., Wei, J., Zivin, J.A. Stroke (2002)
- Development of thrombolytic therapy for stroke: a perspective. Lapchak, P.A. Expert. Opin. Investig. Drugs (2002)
- NXY-059. Centaur. Lapchak, P.A. Curr. Opin. Investig. Drugs (2002)
- Pharmacological effects of the spin trap agents N-t-butyl-phenylnitrone (PBN) and 2,2,6, 6-tetramethylpiperidine-N-oxyl (TEMPO) in a rabbit thromboembolic stroke model: combination studies with the thrombolytic tissue plasminogen activator. Lapchak, P.A., Chapman, D.F., Zivin, J.A. Stroke (2001)
- Neuroprotection by the selective cyclooxygenase-2 inhibitor SC-236 results in improvements in behavioral deficits induced by reversible spinal cord ischemia. Lapchak, P.A., Araujo, D.M., Song, D., Zivin, J.A. Stroke (2001)
- Reducing bleeding complications after thrombolytic therapy for stroke: clinical potential of metalloproteinase inhibitors and spin trap agents. Lapchak, P.A., Araujo, D.M. CNS. Drugs (2001)
- Dehydroepiandrosterone sulfate is neuroprotective in a reversible spinal cord ischemia model: possible involvement of GABA(A) receptors. Lapchak, P.A., Chapman, D.F., Nunez, S.Y., Zivin, J.A. Stroke (2000)
- Metalloproteinase inhibition reduces thrombolytic (tissue plasminogen activator)-induced hemorrhage after thromboembolic stroke. Lapchak, P.A., Chapman, D.F., Zivin, J.A. Stroke (2000)
- Prosaptide exacerbates ischemia-induced behavioral deficits in vivo; an effect that does not involve mitogen-activated protein kinase activation. Lapchak, P.A., Araujo, D.M., Shackelford, D.A., Zivin, J.A. Neuroscience (2000)
