Rainer H. Straub
Laboratory of Experimental Rheumatology and Neuroendocrino-Immunology
Division of Rheumatology
Department of Internal Medicine I
University Hospital
Germany
Name/email consistency: high
- Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1β/TNF. Haas, S., Straub, R.H. Arthritis Res. Ther. (2012)
- Evolutionary medicine and chronic inflammatory state-known and new concepts in pathophysiology. Straub, R.H. J. Mol. Med. (2012)
- Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases. Straub, R.H., Cutolo, M., Buttgereit, F., Pongratz, G. J. Intern. Med. (2010)
- Acute cold stress in rheumatoid arthritis inadequately activates stress responses and induces an increase of interleukin 6. Straub, R.H., Pongratz, G., Hirvonen, H., Pohjolainen, T., Mikkelsson, M., Leirisalo-Repo, M. Ann. Rheum. Dis. (2009)
- Neuronally released sympathetic neurotransmitters stimulate splenic interferon-gamma secretion from T cells in early type II collagen-induced arthritis. Straub, R.H., Rauch, L., Fassold, A., Lowin, T., Pongratz, G. Arthritis Rheum. (2008)
- Increased cortisol relative to adrenocorticotropic hormone predicts improvement during anti-tumor necrosis factor therapy in rheumatoid arthritis. Straub, R.H., Pongratz, G., Cutolo, M., Wijbrandts, C.A., Baeten, D., Fleck, M., Atzeni, F., Grunke, M., Kalden, J.R., Schölmerich, J., Lorenz, H.M., Tak, P.P., Sarzi-Puttini, P. Arthritis Rheum. (2008)
- Antiinflammatory role of endomorphins in osteoarthritis, rheumatoid arthritis, and adjuvant-induced polyarthritis. Straub, R.H., Wolff, C., Fassold, A., Hofbauer, R., Chover-Gonzalez, A., Richards, L.J., Jessop, D.S. Arthritis Rheum. (2008)
- Anti-inflammatory role of sympathetic nerves in chronic intestinal inflammation. Straub, R.H., Grum, F., Strauch, U., Capellino, S., Bataille, F., Bleich, A., Falk, W., Schölmerich, J., Obermeier, F. Gut (2008)
- Higher physical activity is associated with increased androgens, low interleukin 6 and less aortic calcification in peripheral obese elderly women. Straub, R.H., Tankó, L.B., Christiansen, C., Larsen, P.J., Jessop, D.S. J. Endocrinol. (2008)
- The complex role of estrogens in inflammation. Straub, R.H. Endocr. Rev. (2007)
- Autoimmune disease and innervation. Straub, R.H. Brain Behav. Immun. (2007)
- Circadian rhythms in rheumatoid arthritis: implications for pathophysiology and therapeutic management. Straub, R.H., Cutolo, M. Arthritis Rheum. (2007)
- The role of the sympathetic nervous system in intestinal inflammation. Straub, R.H., Wiest, R., Strauch, U.G., Härle, P., Schölmerich, J. Gut (2006)
- Bottom-up and top-down signaling of IL-6 with and without habituation?. Straub, R.H. Brain Behav. Immun. (2006)
- Anti-interleukin-6 receptor antibody therapy favors adrenal androgen secretion in patients with rheumatoid arthritis: a randomized, double-blind, placebo-controlled study. Straub, R.H., Härle, P., Yamana, S., Matsuda, T., Takasugi, K., Kishimoto, T., Nishimoto, N. Arthritis Rheum. (2006)
- Tumor necrosis factor-neutralizing therapies improve altered hormone axes: an alternative mode of antiinflammatory action. Straub, R.H., Härle, P., Sarzi-Puttini, P., Cutolo, M. Arthritis Rheum. (2006)
- Sympathetic neurotransmitters in joint inflammation. Straub, R.H., Härle, P. Rheum. Dis. Clin. North Am. (2005)
- Autonomic dysfunction in rheumatic diseases. Straub, R.H., Baerwald, C.G., Wahle, M., Jänig, W. Rheum. Dis. Clin. North Am. (2005)
- How psychological stress via hormones and nerve fibers may exacerbate rheumatoid arthritis. Straub, R.H., Dhabhar, F.S., Bijlsma, J.W., Cutolo, M. Arthritis Rheum. (2005)
- Anti-tumour necrosis factor antibody treatment does not change serum levels of cortisol binding globulin in patients with rheumatoid arthritis but it increases androstenedione relative to cortisol. Straub, R.H., Sarzi-Puttini, P., Atzeni, F., Buttgereit, F., Carrabba, M., Cutolo, M. Ann. Rheum. Dis. (2005)
- Key role of the sympathetic microenvironment for the interplay of tumour necrosis factor and interleukin 6 in normal but not in inflamed mouse colon mucosa. Straub, R.H., Stebner, K., Härle, P., Kees, F., Falk, W., Schölmerich, J. Gut (2005)
- Benefit of pregnancy in inflammatory arthritis. Straub, R.H., Buttgereit, F., Cutolo, M. Ann. Rheum. Dis. (2005)
- Sex hormone concentrations in patients with rheumatoid arthritis are not normalized during 12 weeks of anti-tumor necrosis factor therapy. Straub, R.H., Härle, P., Atzeni, F., Weidler, C., Cutolo, M., Sarzi-Puttini, P. J. Rheumatol. (2005)
- Ablation of the sympathetic nervous system decreases gram-negative and increases gram-positive bacterial dissemination: key roles for tumor necrosis factor/phagocytes and interleukin-4/lymphocytes. Straub, R.H., Pongratz, G., Weidler, C., Linde, H.J., Kirschning, C.J., Glück, T., Schölmerich, J., Falk, W. J. Infect. Dis. (2005)
- Adrenal and gonadal hormone variations during a febrile attack in a woman with tumor necrosis factor receptor-associated periodic syndrome. Straub, R.H., Härle, P., Kriegel, M., Schölmerich, J., Lorenz, H.M. J. Clin. Endocrinol. Metab. (2005)
- Renal clearance and daily excretion of cortisol and adrenal androgens in patients with rheumatoid arthritis and systemic lupus erythematosus. Straub, R.H., Weidler, C., Demmel, B., Herrmann, M., Kees, F., Schmidt, M., Schölmerich, J., Schedel, J. Ann. Rheum. Dis. (2004)
- Complexity of the bi-directional neuroimmune junction in the spleen. Straub, R.H. Trends Pharmacol. Sci. (2004)
- Long-term anti-tumor necrosis factor antibody therapy in rheumatoid arthritis patients sensitizes the pituitary gland and favors adrenal androgen secretion. Straub, R.H., Pongratz, G., Schölmerich, J., Kees, F., Schaible, T.F., Antoni, C., Kalden, J.R., Lorenz, H.M. Arthritis Rheum. (2003)
- The multiple facets of premature aging in rheumatoid arthritis. Straub, R.H., Schölmerich, J., Cutolo, M. Arthritis Rheum. (2003)
- Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases. Straub, R.H., Besedovsky, H.O. FASEB J. (2003)
- Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease: role of interleukin-6 and tumour necrosis factor. Straub, R.H., Lehle, K., Herfarth, H., Weber, M., Falk, W., Preuner, J., Scholmerich, J. Eur. J. Endocrinol. (2002)
- Immunoregulation of IL-6 secretion by endogenous and exogenous adenosine and by exogenous purinergic agonists in splenic tissue slices. Straub, R.H., Pongratz, G., Günzler, C., Michna, A., Baier, S., Kees, F., Falk, W., Schölmerich, J. J. Neuroimmunol. (2002)
- Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease?. Straub, R.H., Herfarth, H., Falk, W., Andus, T., Schölmerich, J. J. Neuroimmunol. (2002)
- Infusion of epinephrine decreases serum levels of cortisol and 17-hydroxyprogesterone in patients with rheumatoid arthritis. Straub, R.H., Kittner, J.M., Heijnen, C., Schedlowski, M., Schmidt, R.E., Jacobs, R. J. Rheumatol. (2002)
- The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects. Straub, R.H., Schuld, A., Mullington, J., Haack, M., Schölmerich, J., Pollmächer, T. J. Endocrinol. (2002)
- The process of aging changes the interplay of the immune, endocrine and nervous systems. Straub, R.H., Cutolo, M., Zietz, B., Schölmerich, J. Mech. Ageing Dev. (2001)
- Hormone replacement therapy and interrelation between serum interleukin-6 and body mass index in postmenopausal women: a population-based study. Straub, R.H., Hense, H.W., Andus, T., Schölmerich, J., Riegger, G.A., Schunkert, H. J. Clin. Endocrinol. Metab. (2000)
- Neurotransmitters of the sympathetic nerve terminal are powerful chemoattractants for monocytes. Straub, R.H., Mayer, M., Kreutz, M., Leeb, S., Schölmerich, J., Falk, W. J. Leukoc. Biol. (2000)
- A bacteria-induced switch of sympathetic effector mechanisms augments local inhibition of TNF-alpha and IL-6 secretion in the spleen. Straub, R.H., Linde, H.J., Männel, D.N., Schölmerich, J., Falk, W. FASEB J. (2000)
- Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases--substitutes of adrenal and sex hormones. Straub, R.H., Schölmerich, J., Zietz, B. Z. Rheumatol (2000)
- Favorable role of interleukin 10 in patients with polymyalgia rheumatica. Straub, R.H., Herfarth, H.H., Rinkes, B., Konecna, L., Glück, T., von Landenberg, P., Georgi, J., Helmke, K., Schölmerich, J., Vaith, P., Lang, B. J. Rheumatol. (1999)
- Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. Straub, R.H., Konecna, L., Hrach, S., Rothe, G., Kreutz, M., Schölmerich, J., Falk, W., Lang, B. J. Clin. Endocrinol. Metab. (1998)
- Dialogue between the CNS and the immune system in lymphoid organs. Straub, R.H., Westermann, J., Schölmerich, J., Falk, W. Immunol. Today (1998)
- Association of autonomic nervous hyperreflexia and systemic inflammation in patients with Crohn's disease and ulcerative colitis. Straub, R.H., Antoniou, E., Zeuner, M., Gross, V., Schölmerich, J., Andus, T. J. Neuroimmunol. (1997)
