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COG4  -  component of oligomeric golgi complex 4

Homo sapiens

Synonyms: CDG2J, COD1, COG complex subunit 4, Component of oligomeric Golgi complex 4, Conserved oligomeric Golgi complex subunit 4, ...

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  • Three complexes that have previously been partially characterized include (a) the Golgi transport complex (GTC), identified in an in vitro membrane transport assay, (b) the ldlCp complex, identified in analyses of CHO cell mutants with defects in Golgi-associated glycosylation reactions, and (c) the mammalian Sec34 complex, identified by homology to yeast Sec34p, implicated in vesicular transport. We show that these three complexes are identical and rename them the conserved oligomeric Golgi (COG) complex. The COG complex comprises four previously characterized proteins (Cog1/ldlBp, Cog2/ldlCp, Cog3/Sec34, and Cog5/GTC-90), three homologues of yeast Sec34/35 complex subunits (Cog4, -6, and -8), and a previously unidentified Golgi-associated protein (Cog7) [1].
  • Knockdown (KD) of subunits of the conserved oligomeric Golgi (COG) complex significantly delays SubAB cytotoxicity and blocks SubAB trafficking to the cis Golgi [2].
  • Cell surface lectin staining, examination of Golgi glycosyltransferases stability and localization, and matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) analysis were employed to investigate conserved oligomeric Golgi (COG)-dependent glycosylation defects in HeLa cells. Both Griffonia simplicifolia lectin-II and Galanthus nivalus lectins were specifically bound to the plasma membrane glycoconjugates of COG-depleted cells, indicating defects in activity of medial- and trans-Golgi-localized enzymes. In response to siRNA-induced depletion of COG complex subunits, several key components of Golgi glycosylation machinery, including MAN2A1, MGAT1, B4GALT1 and ST6GAL1, were severely mislocalized [3].
  • COG complex KO cell lines were uniformly deficient in cis/medial-Golgi glycosylation and each had nearly abolished binding of Cholera toxin [4].


  1. Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. Ungar, D., Oka, T., Brittle, E.E., Vasile, E., Lupashin, V.V., Chatterton, J.E., Heuser, J.E., Krieger, M., Waters, M.G. J. Cell. Biol. (2002) [Pubmed]
  2. The COG complex, Rab6 and COPI define a novel Golgi retrograde trafficking pathway that is exploited by SubAB toxin. Smith, R.D., Willett, R., Kudlyk, T., Pokrovskaya, I., Paton, A.W., Paton, J.C., Lupashin, V.V. Traffic. (2009) [Pubmed]
  3. Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery. Pokrovskaya, I.D., Willett, R., Smith, R.D., Morelle, W., Kudlyk, T., Lupashin, V.V. Glycobiology. (2011) [Pubmed]
  4. COG Complex Complexities: Detailed Characterization of a Complete Set of HEK293T Cells Lacking Individual COG Subunits. Bailey Blackburn, J., Pokrovskaya, I., Fisher, P., Ungar, D., Lupashin, V.V. Front. Cell. Dev. Biol. (2016) [Pubmed]
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