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Gene Review

TET2  -  tet methylcytosine dioxygenase 2

Homo sapiens

Synonyms: FLJ20032, KIAA1546, MDS, Methylcytosine dioxygenase TET2, Nbla00191

Disease relevance of TET2


  • Analogous to TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA.
  • TET2 is frequently mutated in myeloproliferative disorders (MPD), i.e., Chronic myelogenous leukemia (CML), Polycythemia vera (PV), Essential thrombocytosis (ET) and Myelofibrosis (MF).
  • TET2 is frequently mutated in myelodysplastic syndromes.



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