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Gene Review

PPP1R14D  -  protein phosphatase 1, regulatory...

Homo sapiens

Synonyms: CPI17-like, FLJ20251, GBPI, GBPI-1, GBPI1, ...
  • Human GBPI-1 mRNA encodes a 145-amino-acid, 16.5 kDa protein with pI 7.92 [1]
  • Recombinant GBPI-1fusion protein inhibits PP1 activity with IC50 =3 nM after phosphorylation by PKC. GBPI phosphorylated with PKC activates PP2A activity by>50% at submicromolar concentrations [1]
  • When PKC-phosphorylated GBPI-1 is further phosphorylated by PKA, it no longer inhibits PP1. Thus, GBPI-1 is well positioned to integrate PKC and PKA modulation of PP1 to regulate differential protein phosphorylation patterns in brain and gut [1] [2].
  • GBPI is implicated in carcinogenesis and its mRNA decreased about 2-3 fold in colon carcinoma vs normal colon tissue  [3] [4] [5]


  1. GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA. Liu, Q.R., Zhang, P.W., Lin, Z., Li, Q.F., Woods, A.S., Troncoso, J., Uhl, G.R. Biochem. J. (2004) [Pubmed]
  2. Families of protein phosphatase 1 modulators activated by protein kinases a and C: focus on brain. Liu, Q.R., Gong, J.P., Uhl, G.R. Prog. Nucleic. Acid. Res. Mol. Biol. (2005) [Pubmed]
  3. Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. Skrzypczak, M., Goryca, K., Rubel, T., Paziewska, A., Mikula, M., Jarosz, D., Pachlewski, J., Oledzki, J., Ostrowski, J. PLoS. One. (2010) [Pubmed]
  4. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Kaiser, S., Park, Y.K., Franklin, J.L., Halberg, R.B., Yu, M., Jessen, W.J., Freudenberg, J., Chen, X., Haigis, K., Jegga, A.G., Kong, S., Sakthivel, B., Xu, H., Reichling, T., Azhar, M., Boivin, G.P., Roberts, R.B., Bissahoyo, A.C., Gonzales, F., Bloom, G.C., Eschrich, S., Carter, S.L., Aronow, J.E., Kleimeyer, J., Kleimeyer, M., Ramaswamy, V., Settle, S.H., Boone, B., Levy, S., Graff, J.M., Doetschman, T., Groden, J., Dove, W.F., Threadgill, D.W., Yeatman, T.J., Coffey RJ, J.r., Aronow, B.J. Genome. Biol. (2007) [Pubmed]
  5. A 'metastasis-prone' signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics. Hong, Y., Downey, T., Eu, K.W., Koh, P.K., Cheah, P.Y. Clin. Exp. Metastasis. (2010) [Pubmed]
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