Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

nagK - N-acetyl-D-glucosamine kinase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1105, JW1105, ycfX

Uehara, T. et al.

Uehara, Park,

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Disease relevance of nagK

A nagK deletion mutant lacked phosphorylated GlcNAc in its cytoplasm, and the cell extract of the mutant did not phosphorylate GlcNAc, indicating that NagK is the only GlcNAc kinase expressed in E. coli [1].

Associations of nagK with chemical compounds

Unexpectedly, GlcNAc did not accumulate in a nagK nagEBACD mutant, though both GlcNAc and GlcNAc-6-P accumulate in the nagEBACD mutant, suggesting the existence of an alternative pathway (presumably repressed by GlcNAc-6-P) that reutilizes GlcNAc without the involvement of NagK [1].

References

The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling. Uehara, T., Park, J.T. J. Bacteriol. (2004) [Pubmed]

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