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Chemical Compound Review

m-Phenylphenol     3-phenylphenol

Synonyms: Biphenyl-3-ol, SureCN51869, CHEMBL122570, AG-G-05255, ACMC-209m2d, ...
 
 
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High impact information on m-Hydroxydiphenyl

  • This assay is a modification of a commonly used procedure, viz. hydrolysis of uronic acid containing carbohydrate polymers in 80% sulfuric acid containing tetraborate ions at 80 degrees C followed by a coloring step with an m-hydroxydiphenyl reagent at room temperature [1].
  • In the Sprague-Dawley rat, a slight increase in hydroxylation leading to 3-hydroxybiphenyl was observed [2].
  • 1. 4-Hydroxylation was a major route of biphenyl metabolism in liver microsomes from control and phenobarbitone-pretreated rats, with 2- and 3-hydroxybiphenyl as lesser metabolites [3].

References

  1. A microtiter plate assay for the determination of uronic acids. van den Hoogen, B.M., van Weeren, P.R., Lopes-Cardozo, M., van Golde, L.M., Barneveld, A., van de Lest, C.H. Anal. Biochem. (1998) [Pubmed]
  2. The effect of phenobarbital and beta-naphthoflavone induction on the metabolism of biphenyl in the rat and mouse. Halpaap-Wood, K., Horning, E.C., Horning, M.G. Drug Metab. Dispos. (1981) [Pubmed]
  3. Activation of hepatic microsomal biphenyl 2-hydroxylation by corticosteroids. Benford, D.J., Bridges, J.W., Parke, D.V. Xenobiotica (1980) [Pubmed]
 
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