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Chemical Compound Review:

Emoxipin 2-ethyl-6-methyl-pyridin-3-ol

Synonyms: Emoxypie, Emoxipine, Emoxypine, Epigid, Epygid, ...

Kuznetsov, D.A. et al., Novikov, K. et al., Nakaidze, N.S.h. et al.

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High impact information on Epigid

Intraperitoneal injection of different amounts of Epygid (2-ethyl-6-methyl-3-oxypyridine) to 3- and 18-month-old rats led to significant reduction of translating activity in vitro of membrane-bound polysomes of brain cells, but not of free polysomes, more so for bound polysomes from 18-month-old animals than those from 3 months old [1].
The phenomenon may be related to incorporation of Epygid into the membranes of endoplasmic reticulum which contain a part of cell polysomes on their surface [1].
There is experimental evidence about the relationship between these two processes in hepatocytes, i.e. addition of 2-ethyl-6-methyl-3-hydroxypyridine, 2, 6-di(tert)butyl-4-hydroxytoluene, and 1, 2, 3-tri-hydroxybenzene to the incubation medium leads to inhibition of lipid peroxidation and stabilization of cytochrome P-450 [2].
Influence of the geroprotector 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride on the lifetime of Drosophila melanogaster [3].

References

Epygid: a new Soviet antioxidant promoted the selective inhibition of membrane-dependent protein synthesis in the brain. Kuznetsov, D.A., Sibileva, T.M., Musajev, N.I. Toxicol. Appl. Pharmacol. (1986) [Pubmed]
Stabilization of cytochrome P-450 in hepatocytes by free radical scavengers of different nature. Novikov, K., Kagan, V. Acta physiologica et pharmacologica Bulgarica. (1985) [Pubmed]
Influence of the geroprotector 2-ethyl-6-methyl-3-hydroxypyridine hydrochloride on the lifetime of Drosophila melanogaster. Nakaidze, N.S.h., Obukhova, L.K., Smirnov, L.D., Akif'ev, A.P. Biology bulletin of the Academy of Sciences of the USSR. (1978) [Pubmed]

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