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Chemical Compound Review:

Isocytisoside 5,7-dihydroxy-2-(4- methoxyphenyl)-6-[(2R...

Synonyms: AC1Q6BBM, AR-1H2641, AR-1H2642, AC1L4O6I

Murias, M. et al., Jodynis-Liebert, J. et al., Bylka, W. et al., Bylka, W. et al.

Murias, Jodynis-Liebert, Matławska, Bylka, Bylka, Szaufer-Hajdrych, Matławska, Goślińska,

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Disease relevance of Isocytisoside

The results have shown that the extracts, subextracts and isocytisoside inhibit growth of all studied micro-organisms, revealing the greatest activity against Gram-positive Staphylococcus aureus, Staph. epidermidis and the mould Aspergillus niger [1].

High impact information on Isocytisoside

Antioxidant activity of isocytisoside and extracts of Aquilegia vulgaris [2].
Inhibition both non-enzymatic (IC50: 150-219 microg/ml) and enzymatic (IC50: 23-60 microg/ml) microsomal lipid peroxidation was observed, the extracts being more active than isocytisoside [2].
The cytochrome P450 contents, and the activities of NADPH-cytochrome P450 reductase and two monooxygenases were not affected by the extracts and isocytisoside [3].
Rats pretreated with acetaminophen (N-acetyl-p-aminophenol, APAP) (600 mg/kg b.w., p.o.) were administered with ethanol and ethyl acetate extracts as well as with isocytisoside (100 mg/kg b.w., p.o.) obtained from Aquilegia vulgaris (L.) (Ranunculaceae) herb [3].
Flavonoids from Aquilegia vulgaris L. Part I. Isocytisoside and its derivatives [4].

Associations of Isocytisoside with other chemical compounds

Two extracts (ethyl acetate and ethanol) and isocytisoside obtained from Aquilegia vulgaris were tested for their antioxidant and free radical scavenging activity in vitro [2].

References

Antimicrobial activity of isocytisoside and extracts of Aquilegia vulgaris L. Bylka, W., Szaufer-Hajdrych, M., Matławska, I., Goślińska, O. Lett. Appl. Microbiol. (2004) [Pubmed]
Antioxidant activity of isocytisoside and extracts of Aquilegia vulgaris. Murias, M., Jodynis-Liebert, J., Matławska, I., Bylka, W. Fitoterapia (2005) [Pubmed]
Protective effect of Aquilegia vulgaris (L.) on APAP-induced oxidative stress in rats. Jodynis-Liebert, J., Matławska, I., Bylka, W., Murias, M. Journal of ethnopharmacology. (2005) [Pubmed]
Flavonoids from Aquilegia vulgaris L. Part I. Isocytisoside and its derivatives. Bylka, W., Matławska, I. Acta poloniae pharmaceutica. (1997) [Pubmed]

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