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Chemical Compound Review

GuoPP[NH]P     [(2R,3S,4R,5R)-5-(2-amino-6- oxo-3H-purin-9...

Synonyms: Guopp(CH2)P, AC1Q6TCM, AR-1G9249, AC1L535X
 
 
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High impact information on Guopp(CH2)P

 

Anatomical context of Guopp(CH2)P

  • Treatment of rat liver EF-2 with N-ethylmaleimide (MalNEt) did not affect the direct interactions of the factor with guanine nucleotides or with ribosomes, but inhibited the binding of guanosine 5'-(beta, gamma-methylene)triphosphate (GuoPP(CH2)P) to the EF-2-ribosome complex [3].

References

  1. Refined crystal structures of guanine nucleotide complexes of adenylosuccinate synthetase from Escherichia coli. Poland, B.W., Hou, Z., Bruns, C., Fromm, H.J., Honzatko, R.B. J. Biol. Chem. (1996) [Pubmed]
  2. Nucleotide binding to elongation factor 2 inactivated by diphtheria toxin. Burns, G., Abraham, A.K., Vedeler, A. FEBS Lett. (1986) [Pubmed]
  3. Functional groups of elongation factor 2 involved in interactions with guanosine nucleotides and ribosomes. Nurten, R., Aktar, N.B., Bermek, E. FEBS Lett. (1983) [Pubmed]
 
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