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Chemical Compound Review

Moscatilin     4-[2-(4-hydroxy-3-methoxy- phenyl)ethyl]-2...

Synonyms: Dendrophenol, Aloifol II, CHEMBL374047, AC1L41WY, 108853-14-1, ...
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High impact information on Moscatilin

  • However, unlike some G2 arresting agents, moscatilin has no detectable inhibitory effect on cyclin B-cdc-2 kinase activity [1].
  • Our results have shown that moscatilin exerts potent cytotoxic effect against cancer cell lines derived from different tissue origins, including those from the placenta, stomach, and lung, but not those from the liver [1].
  • In addition, we have found that the mechanism of action of moscatilin may be related to its ability to induce a G2 phase arrest in responsive cells [1].
  • When using 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide (furylfuramide) as the mutagen, moscatilin suppressed 85% of the umu gene expression compared to the controls at <0.73 micromol/mL, with an ID(50) value of 0.41 micromol/mL [2].
  • Interestingly, moscatilin almost completely suppressed (97%) the AFB(1)-induced SOS response at concentrations <0.73 micromol/mL, with an ID(50) of 0.08 micromol/mL [2].

Gene context of Moscatilin


Analytical, diagnostic and therapeutic context of Moscatilin


  1. Moscatilin from the orchid Dendrobrium loddigesii is a potential anticancer agent. Ho, C.K., Chen, C.C. Cancer Invest. (2003) [Pubmed]
  2. Moscatilin from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. Miyazawa, M., Shimamura, H., Nakamura, S., Sugiura, W., Kosaka, H., Kameoka, H. J. Agric. Food Chem. (1999) [Pubmed]
  3. Moscatilin induces apoptosis in human colorectal cancer cells: a crucial role of c-Jun NH2-terminal protein kinase activation caused by tubulin depolymerization and DNA damage. Chen, T.H., Pan, S.L., Guh, J.H., Liao, C.H., Huang, D.Y., Chen, C.C., Teng, C.M. Clin. Cancer Res. (2008) [Pubmed]
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