Disease relevance of Bethanidine

• Patients presenting with only ventricular fibrillation may have a more favorable response to bethanidine sulfate [1].
• Bethanidine sulfate: efficacy in prevention of ventricular tachyarrhythmias during programmed stimulation. Report of a multicenter study of 56 patients [1].
• Acute electrophysiologic effects of bethanidine sulfate in patients with ventricular tachycardia or fibrillation [2].
• Orthostatic hypotension was a prominent side effect of bethanidine sulfate therapy, but could be reversed in most patients by concomitant administration of protriptyline [3].
• Thus, although bethanidine sulfate therapy is difficult to initiate because of orthostatic hypotensive side effects, it may be useful in treating patients at high risk of recurrent cardiac arrest [3].

High impact information on Bethanidine

• Electrophysiological effects of bethanidine sulfate on guinea-pig papillary muscle [4].
• Bretylium tosylate and bethanidine sulfate were studied in two models of experimental myocardial ischemia [5].
• Bethanidine sulfate in the dosages used usually does not prevent the induction of VT by programmed ventricular stimulation and frequently causes serious toxicity [6].
• Programmed ventricular stimulation was used to test oral bethanidine sulfate in 10 patients with life-threatening ventricular arrhythmias [6].
• Electrophysiological effects of bethanidine sulfate on canine cardiac Purkinje fibers and ventricular muscle cells [7].

Chemical compound and disease context of Bethanidine

• Suppression of ventricular fibrillation and positive inotropic action of bethanidine sulfate, a chemical analog of bretylium tosylate that is well absorbed orally [8].
• Antiarrhythmic, antifibrillatory, and hemodynamic actions of bethanidine sulfate: an orally effective analog of bretylium for suppression of ventricular tachyarrhythmias [9].

Analytical, diagnostic and therapeutic context of Bethanidine

• Ten patients with a history of ventricular tachycardia or ventricular fibrillation underwent electrophysiologic study with programmed stimulation before and 90 minutes after oral administration of bethanidine sulfate, 20 mg/kg [2].

References