Disease relevance of Chingamin

• Effects of superoxide dismutase (SOD), catalase, EGB 761 (Tanakan), and their combination on reperfusion-induced ventricular fibrillation (VF), tachycardia (VT), and the formation of oxygen free radicals were studied after 30 min of global ischemia followed by reperfusion in isolated rat hearts [1].
• The results provide a possible explanation for the clinical efficacy of Tanakan in the treatment of peripheral vascular disease; they also confirm that a single oral dose of 15 ml Tanakan is well tolerated [2].
• OBJECTIVE: To observe the changes in hypertensive cerebral arteriosclerosis and the incidence of stroke in rats following treatment with Tanakan, a preparation of Ginkgo Biloba (GB) [3].
• After 7 days of Tanakan pretreatment, 30 min of ischemia and 24 h of reperfusion, the animals did not show paraplegia [4].

High impact information on Chingamin

• The effects of high-dose steroids and Ginkgo biloba extract (Tanakan); an agent able to improve capillary permeability) were analyzed by means of the two-tailed nonparametric Wilcoxon test [5].
• Tanakan inhibits platelet-activating-factor-induced platelet aggregation in healthy male volunteers [2].
• Tanakan significantly reduced the ischemia/reperfusion-induced inhibition of translation in the neocortex as well as in the highly sensitive hippocampus [6].
• Histochemical analysis of NADPH-diaphorase (NADPH-d) activity was performed on segments of the lumbar spinal cord in rabbit after 7 days pretreatment with the Ginkgo biloba extract Tanakan, and 30 min of ischemia followed by 24 h of reperfusion [4].
• In the next phase of the experiment a second group was initially treated with Tanakan (EGb 761--Ginkgo biloba extract) and then it was submitted to the same chronic stress: this procedure did not bring about the increase of the number of lymphocytes but it significantly improved the function of these cells [7].

Biological context of Chingamin

• Bio-availability studies done on two brands, Avloclor (ICI) with the fastest dissolution rate and Pfizerquine (Pfizer) with the slowest dissolution rate, showed similar areas under the curve (AUC) [8].

Anatomical context of Chingamin

• The administration of chloroquine (Resochin) in rats produces significant changes in the hepatocytic organelles, which are described by morphometric and biochemical methods [9].

Associations of Chingamin with other chemical compounds

• An open study to investigate the PAF-acether antagonist activity of Tanakan in healthy male volunteers examined the effect of a single 15-ml oral dose on ex vivo platelet aggregation induced by adrenaline, adenosine diphosphate (ADP), collagen or PAF-acether [2].

Analytical, diagnostic and therapeutic context of Chingamin

• For reinvestigation of the metabolism of 7-chloro-4-(4-diethylamino-1-methylbutylamino)quinoline (chloroquine, Resochin), urine samples from patients and volunteers with single or repeated chloroquine doses were collected and analyzed by gas chromatography, thin-layer chromatography, and gas chromatography/mass spectrometry [10].

References