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Chemical Compound Review

Tanakene     N'-(7-chloroquinolin-4-yl)- N,N-diethyl...

Synonyms: Miniquine, CHEMBL1326, Ipsen 225, SureCN40829, TCMDC-123988, ...
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Disease relevance of Chingamin

 

High impact information on Chingamin

  • The effects of high-dose steroids and Ginkgo biloba extract (Tanakan); an agent able to improve capillary permeability) were analyzed by means of the two-tailed nonparametric Wilcoxon test [5].
  • Tanakan inhibits platelet-activating-factor-induced platelet aggregation in healthy male volunteers [2].
  • Tanakan significantly reduced the ischemia/reperfusion-induced inhibition of translation in the neocortex as well as in the highly sensitive hippocampus [6].
  • Histochemical analysis of NADPH-diaphorase (NADPH-d) activity was performed on segments of the lumbar spinal cord in rabbit after 7 days pretreatment with the Ginkgo biloba extract Tanakan, and 30 min of ischemia followed by 24 h of reperfusion [4].
  • In the next phase of the experiment a second group was initially treated with Tanakan (EGb 761--Ginkgo biloba extract) and then it was submitted to the same chronic stress: this procedure did not bring about the increase of the number of lymphocytes but it significantly improved the function of these cells [7].
 

Biological context of Chingamin

  • Bio-availability studies done on two brands, Avloclor (ICI) with the fastest dissolution rate and Pfizerquine (Pfizer) with the slowest dissolution rate, showed similar areas under the curve (AUC) [8].
 

Anatomical context of Chingamin

  • The administration of chloroquine (Resochin) in rats produces significant changes in the hepatocytic organelles, which are described by morphometric and biochemical methods [9].
 

Associations of Chingamin with other chemical compounds

  • An open study to investigate the PAF-acether antagonist activity of Tanakan in healthy male volunteers examined the effect of a single 15-ml oral dose on ex vivo platelet aggregation induced by adrenaline, adenosine diphosphate (ADP), collagen or PAF-acether [2].
 

Analytical, diagnostic and therapeutic context of Chingamin

References

  1. Effects of SOD, catalase, and a novel antiarrhythmic drug, EGB 761, on reperfusion-induced arrhythmias in isolated rat hearts. Tosaki, A., Droy-Lefaix, M.T., Pali, T., Das, D.K. Free Radic. Biol. Med. (1993) [Pubmed]
  2. Tanakan inhibits platelet-activating-factor-induced platelet aggregation in healthy male volunteers. Guinot, P., Caffrey, E., Lambe, R., Darragh, A. Haemostasis (1989) [Pubmed]
  3. A preliminary investigation of Tanakan in the treatment of hypertensive arteriosclerosis and stroke in rats. Fang, Y., Huang, R., Zhang, Y., Lin, J., Li, J. Chin. Med. J. (2000) [Pubmed]
  4. NADPH-diaphorase activity in the spinal cord after ischemic injury and the effects of pretreatment with Ginkgo biloba extract (EGb 761). Mechírová, E., Domoráková, I. Acta Histochem. (2002) [Pubmed]
  5. Vascular hyperpermeability in nephrotic edema. Rostoker, G., Behar, A., Lagrue, G. Nephron (2000) [Pubmed]
  6. Effect of Tanakan on postischemic activity of protein synthesis machinery in the rat brain. Hrehorovská, M., Burda, J., Domoráková, I., Mechírová, E. Gen. Physiol. Biophys. (2004) [Pubmed]
  7. Effect of the EGb 761 (Ginkgo bilboa extract) on primary immune response in experimental chronic stress. Turcan, M., Cozmei, C., Carasevici, E., Haulică, I. Revista medico-chirurgicală a Societăţii de Medici şi Naturalişti din Iaşi. (1995) [Pubmed]
  8. Comparative bio-availability characteristics of different brands of chloroquine available in Nigeria. Aderounmu, A.F., Fleckenstein, L. African journal of medicine and medical sciences. (1982) [Pubmed]
  9. Effects of chloroquine on hepatocytic organelles in rat. Singh, K.P., Krause, W., David, H., von Zglinicki, T. Experimental pathology. (1985) [Pubmed]
  10. Urinary metabolism of chloroquine. Köppel, C., Tenczer, J., Ibe, K. Arzneimittel-Forschung. (1987) [Pubmed]
 
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