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Chemical Compound Review

SureCN412849     (S)-[(4S,5S,7S)-5-ethenyl-1...

Synonyms: SureCN412850, CCRIS 5754, KST-1A6663, AR-1A7331, LS-141253, ...
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Disease relevance of Quinine

  • Treatment may be delayed because the therapy recommended for severe or complicated disease, intravenous quinine dihydrochloride, is available only from the Centers for Disease Control. We studied 17 patients who were treated for severe or complicated P. falciparum malaria in the United States between 1985 and 1987 [1].
  • Two hundred seventy-six received intramuscular quinine dihydrochloride (20 mg per kilogram of body weight followed by 10 mg per kilogram every eight hours), and 284 received intramuscular artemether (4 mg per kilogram followed by 2 mg per kilogram every eight hours) [2].
  • One hundred and two children aged 0-10 years with cerebral malaria (Blantyre coma score of 2 or less) were randomly treated either with intramuscular arteether (3.2 mg/kg on Day 0, followed by 1.6 mg/kg on Days 1 to 4) or intravenous (i.v.) quinine dihydrochloride (20 mg of the salt/kg, followed by 10 mg of the salt/kg every 8 hr up to Day 6) [3].
  • In the third patient, an unreduced dose of quinine dihydrochloride 25.7 mg.kg-1.day-1 was employed, resulting in plasma concentrations above 15 mg/l, which is generally assumed to be toxic, although, no sign of acute quinine toxicity was seen [4].
  • In nine healthy subjects hearing loss was documented at 2-4 h after infusion of Quinine-dihydrochloride at a mean maximal plasma quinine concentration of only 2 mg/l. In one healthy subject a persistent loss occurred of 20 dB at 14 kHz in one ear [5].
 

High impact information on Quinine

 

Chemical compound and disease context of Quinine

 

Biological context of Quinine

 

Analytical, diagnostic and therapeutic context of Quinine

References

  1. Treatment of severe malaria in the United States with a continuous infusion of quinidine gluconate and exchange transfusion. Miller, K.D., Greenberg, A.E., Campbell, C.C. N. Engl. J. Med. (1989) [Pubmed]
  2. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria. Tran, T.H., Day, N.P., Nguyen, H.P., Nguyen, T.H., Tran, T.H., Pham, P.L., Dinh, X.S., Ly, V.C., Ha, V., Waller, D., Peto, T.E., White, N.J. N. Engl. J. Med. (1996) [Pubmed]
  3. Clinical trial of beta-arteether versus quinine for the treatment of cerebral malaria in children in Yaounde, Cameroon. Moyou-Somo, R., Tietche, F., Ondoa, M., Kouemeni, L.E., Ekoe, T., Mbonda, E., Nsangou, C., Jemea, B., Guemkam, G. Am. J. Trop. Med. Hyg. (2001) [Pubmed]
  4. Drug monitoring of quinine by HPLC in cerebral malaria with acute renal failure treated by haemofiltration. Franke, U., Proksch, B., Müller, M., Risler, T., Ehninger, G. Eur. J. Clin. Pharmacol. (1987) [Pubmed]
  5. Ototoxic reactions of quinine in healthy persons and patients with Plasmodium falciparum infection. Tange, R.A., Dreschler, W.A., Claessen, F.A., Perenboom, R.M. Auris, nasus, larynx. (1997) [Pubmed]
  6. Pentoxifylline adjunct improves prognosis of human cerebral malaria in adults. Das, B.K., Mishra, S., Padhi, P.K., Manish, R., Tripathy, R., Sahoo, P.K., Ravindran, B. Trop. Med. Int. Health (2003) [Pubmed]
  7. Bioavailability of sulphate and dihydrochloride salts of quinine. Sowunmi, A., Salako, L.A., Ogunbona, F.A. African journal of medicine and medical sciences. (1994) [Pubmed]
  8. Drug interaction between cyclosporine A and quinine in a renal transplant patient with malaria. Tan, H.W., Ch'ng, S.L. Singapore medical journal. (1991) [Pubmed]
  9. A safe and effective consecutive-infusion regimen for rapid quinine loading in severe falciparum malaria. Davis, T.M., Supanaranond, W., Pukrittayakamee, S., Karbwang, J., Molunto, P., Mekthon, S., White, N.J. J. Infect. Dis. (1990) [Pubmed]
  10. Comparative effects of quinine and quinidine on glucose metabolism in healthy volunteers. Davis, T.M., Karbwang, J., Looareesuwan, S., Turner, R.C., White, N.J. British journal of clinical pharmacology. (1990) [Pubmed]
  11. Ineffectiveness of continuous quinidine gluconate infusion in the treatment of severe chloroquine-resistant Plasmodium falciparum malaria. Matsuura, G.K., Chan, L.A. Drug intelligence & clinical pharmacy. (1988) [Pubmed]
  12. Quinine and severe falciparum malaria in late pregnancy. Looareesuwan, S., Phillips, R.E., White, N.J., Kietinun, S., Karbwang, J., Rackow, C., Turner, R.C., Warrell, D.A. Lancet (1985) [Pubmed]
  13. Pharmacokinetics of quinine in children. Shann, F., Stace, J., Edstein, M. J. Pediatr. (1985) [Pubmed]
  14. Quinine loading dose in cerebral malaria. White, N.J., Looareesuwan, S., Warrell, D.A., Warrell, M.J., Chanthavanich, P., Bunnag, D., Harinasuta, T. Am. J. Trop. Med. Hyg. (1983) [Pubmed]
  15. Serum levels of quinine following intramuscular administration to children. Stace, J., Shann, F.A., Walters, S., Connellan, M., Edstein, M. Papua and New Guinea medical journal. (1983) [Pubmed]
 
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