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Chemical Compound Review:

Dihydrouridine 1-[(2R,3R,4S,5R)-3,4- dihydroxy-5...

Synonyms: SureCN40762, AG-F-97491, CHEBI:23774, HMDB00497, AC1L3RYN, ...

Snider, M.J. et al., Carlow, D.C. et al., Frick, L. et al.

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Disease relevance of 5,6-Dihydrouridine

The crystal structure of an inhibitory complex formed between Escherichia coli cytidine deaminase and the transition-state analog 3,4-dihydrouridine indicates the presence of a short H-bond between Glu-104 and the inhibitor [1].

High impact information on 5,6-Dihydrouridine

The entropic shortcomings of 3,4-dihydrouridine, in capturing all of the free energy involved in binding the actual transition state, may arise from its inability to displace a water molecule that occupies the binding site normally occupied by product ammonia [2].

Associations of 5,6-Dihydrouridine with other chemical compounds

Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and the contribution of the 4-hydroxyl group to its binding affinity [3].

References

Major contribution of a carboxymethyl group to transition-state stabilization by cytidine deaminase: mutation and rescue. Carlow, D.C., Smith, A.A., Yang, C.C., Short, S.A., Wolfenden, R. Biochemistry (1995) [Pubmed]
Site-bound water and the shortcomings of a less than perfect transition state analogue. Snider, M.J., Wolfenden, R. Biochemistry (2001) [Pubmed]
Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and the contribution of the 4-hydroxyl group to its binding affinity. Frick, L., Yang, C., Marquez, V.E., Wolfenden, R. Biochemistry (1989) [Pubmed]

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