Disease relevance of Swl

• Reconstructions from serial sections showed that ganglion cells in Swl were highly irregular in shape [1].
• End-plates, transmission and contractile characteristics of muscles without spindles in the hereditary sensory neuropathy of the Sprawling mouse [2].

High impact information on Swl

• In the mutant mouse Sprawling, a deficiency of sensory ganglion cells is associated with a failure of the development of spindles and tendon organs particularly affecting muscles of the hindleg [2].
• In the normal ganglion cells, nuclei were rounded and central by the 16th foetal day and nuclear indentations were never seen, thus making a clear distinction possible between normal and Swl foetuses [3].
• The foetal and early post-natal development of dorsal root ganglion cells in normal and Sprawling (Swl) mutant mice was studied by light and electron microscopy [3].
• The L4-6 sensory root ganglia of young and adult Sprawling (Swl) and normal mice were studied [1].
• Cell counts showed a great reduction in the total number of ganglion cells in Swl [1].

Anatomical context of Swl

• Quantitative and electron microscopic studies of sensory ganglion cells of the Sprawling mouse [1].
• The structure and composition of peripheral nerves and nerve roots in the Sprawling mouse [4].

Analytical, diagnostic and therapeutic context of Swl

• Peripheral nerves and lumbar nerve roots of Sprawling, a neurological mutant mouse, were examined with light and electron microscopy [4].

References