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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ERLIN2  -  ER lipid raft associated 2

Homo sapiens

Synonyms: C8orf2, Endoplasmic reticulum lipid raft-associated protein 2, Erlin-2, NET32, SPFH domain-containing protein 2, ...
 
 
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High impact information on ERLIN2

  • Owing to their subcellular localization and their presence in lipid rafts, we have named KE04p and C8orf2, ER lipid raft protein (erlin)-1 and erlin-2, respectively [1].
  • The genes FLJ14299, C8orf2, BRF2 and RAB11FIP, map within the 8p11-12 minimal amplicon, two have a putative function consistent with an oncogenic role, these four genes showed a strong correlation between amplification and overexpression and are therefore the best candidate driver oncogenes at 8p12 [2].
  • C8orf2 consisted of 16 exons spanning more than 16.5 kb of genomic DNA, and was expressed ubiquitously in human tissues [3].
 

Biological context of ERLIN2

 

Associations of ERLIN2 with chemical compounds

  • Two of these proteins, KE04p and C8orf2, were found to be highly enriched in the detergent-insoluble, buoyant fraction of sucrose gradients in a cholesterol-dependent manner [1].

References

  1. Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER. Browman, D.T., Resek, M.E., Zajchowski, L.D., Robbins, S.M. J. Cell. Sci. (2006) [Pubmed]
  2. A 1 Mb minimal amplicon at 8p11-12 in breast cancer identifies new candidate oncogenes. Garcia, M.J., Pole, J.C., Chin, S.F., Teschendorff, A., Naderi, A., Ozdag, H., Vias, M., Kranjac, T., Subkhankulova, T., Paish, C., Ellis, I., Brenton, J.D., Edwards, P.A., Caldas, C. Oncogene (2005) [Pubmed]
  3. Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9. Ikegawa, S., Isomura, M., Koshizuka, Y., Nakamura, Y. Cytogenet. Cell Genet. (1999) [Pubmed]
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