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Gene Review: 

Col9a1  -  collagen, type IX, alpha 1

Mus musculus

Synonyms: Col9a-1, Collagen alpha-1(IX) chain
 
 
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Disease relevance of Col9a1

  • OBJECTIVE: To examine the pathogenetic mechanisms of osteoarthritis (OA)-like changes in Col9a1(-/-) mice, which are deficient in type IX collagen [1].
 

High impact information on Col9a1

  • The expression of MMP-13 and DDR-2 protein and the amount of degraded type II collagen were higher in the knee joints of Col9a1(-/-) mice than in their wild-type littermates at the age of 6 months [1].
  • CONCLUSION: Lack of type IX collagen in Col9a1(-/-) mice results in age-dependent OA-like changes in the knee joints and TMJs [1].
  • The sequence specific polymerase chain reaction demonstrated the exclusive expression of short transcriptional isoform of alpha1(IX) collagen (Col9a1) in alveolar bone wound healing, while the long isoform of Col9a1 transcript was absent [2].
  • This was accompanied by increasing expression of nonchondrocytic Col9a1, Col9a2, and Col9a3, first detected at 11.5 dpc [3].
  • Likewise, the present work shows that the mouse Col19a1 gene is located on mouse chromosome 1, region A3, where Col9a1 has also been mapped [4].
 

Biological context of Col9a1

  • In Col9a1-null mutant mice, there were considerable variations in alveolar bone wound healing with the absence of or abnormally organized trabecular bone [2].
  • In addition, using an interspecific backcross panel, we have mapped murine Col9a1 to mouse chromosome 1 [5].
  • Mice lacking collagen IX (Col9a1-/-) are viable and develop an osteoarthritis-like phenotype in knee joints between 9-12 months of age [6].
 

Anatomical context of Col9a1

  • As ciliary epithelial cells become well differentiated 3 weeks after birth, cells expressing the Col9a1 gene were limited to the junction between mature ciliary folds and the neural retina [7].
 

Other interactions of Col9a1

 

Analytical, diagnostic and therapeutic context of Col9a1

References

  1. Pathogenesis of osteoarthritis-like changes in the joints of mice deficient in type IX collagen. Hu, K., Xu, L., Cao, L., Flahiff, C.M., Brussiau, J., Ho, K., Setton, L.A., Youn, I., Guilak, F., Olsen, B.R., Li, Y. Arthritis Rheum. (2006) [Pubmed]
  2. A short isoform of Col9a1 supports alveolar bone repair. Ting, K., Ramachandran, H., Chung, K.S., Shah-Hosseini, N., Olsen, B.R., Nishimura, I. Am. J. Pathol. (1999) [Pubmed]
  3. Type II and type IX collagen transcript isoforms are expressed during mouse testis development. McClive, P.J., Sinclair, A.H. Biol. Reprod. (2003) [Pubmed]
  4. Structure of the human type XIX collagen (COL19A1) gene, which suggests it has arisen from an ancestor gene of the FACIT family. Khaleduzzaman, M., Sumiyoshi, H., Ueki, Y., Inoguchi, K., Ninomiya, Y., Yoshioka, H. Genomics (1997) [Pubmed]
  5. Physical and linkage mapping of the human and murine genes for the alpha 1 chain of type IX collagen (COL9A1). Warman, M.L., Tiller, G.E., Polumbo, P.A., Seldin, M.F., Rochelle, J.M., Knoll, J.H., Cheng, S.D., Olsen, B.R. Genomics (1993) [Pubmed]
  6. The role of collagen II and cartilage fibril-associated molecules in skeletal development. Aszódi, A., Hunziker, E.B., Olsen, B.R., Fässler, R. Osteoarthr. Cartil. (2001) [Pubmed]
  7. Developmental patterns of two alpha 1(IX) collagen mRNA isoforms in mouse. Liu, C.Y., Olsen, B.R., Kao, W.W. Dev. Dyn. (1993) [Pubmed]
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