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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DNAJC19  -  DnaJ (Hsp40) homolog, subfamily C, member 19

Homo sapiens

Synonyms: DnaJ homolog subfamily C member 19, Mitochondrial import inner membrane translocase subunit TIM14, PAM18, Pam18, TIM14, ...
 
 
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High impact information on DNAJC19

  • Upon mixing the proteins in vitro, or when both proteins are co-overexpressed in bacteria, Pam18/Tim14 and Pam16/Tim16 form a heterodimer that is thermally more stable than the individual proteins (T(m) = 41 degrees C) [1].
  • Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition [2].
  • CONCLUSIONS: The DNAJC19 protein was previously localised to the mitochondria in cardiac myocytes, and shares sequence and organisational similarity with proteins from several species including two yeast mitochondrial inner membrane proteins, Mdj2p and Tim14 [2].

References

  1. The Pam18/Tim14-Pam16/Tim16 complex of the mitochondrial translocation motor: The formation of a stable complex from marginally stable proteins. Iosefson, O., Levy, R., Marom, M., Slutsky-Leiderman, O., Azem, A. Protein Sci. (2007) [Pubmed]
  2. Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition. Davey, K.M., Parboosingh, J.S., McLeod, D.R., Chan, A., Casey, R., Ferreira, P., Snyder, F.F., Bridge, P.J., Bernier, F.P. J. Med. Genet. (2006) [Pubmed]
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