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Gene Review

vCD30  -  soluble secreted recptor for CD30 ligand

Cowpox virus

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Disease relevance of vCD30

  • Here, we report the expression of a functional soluble CD30 homologue, viral CD30 (vCD30), encoded by ectromelia (mousepox) virus, a poxvirus that causes a severe disease related to human smallpox [1].
  • Sequence analysis of a region of the genome that is type-specific for cowpox virus identified a gene, vCD30, encoding a soluble, secreted protein that is the fifth member of the tumor necrosis factor receptor family known to be encoded by cowpox virus [2].

High impact information on vCD30

  • The vCD30 protein contains 110 aa, including a 21-residue signal peptide, a potential O-linked glycosylation site, and a 58-aa sequence sharing 51-59% identity with highly conserved extracellular segments of both mouse and human CD30 [2].


  1. Inhibition of type 1 cytokine-mediated inflammation by a soluble CD30 homologue encoded by ectromelia (mousepox) virus. Saraiva, M., Smith, P., Fallon, P.G., Alcami, A. J. Exp. Med. (2002) [Pubmed]
  2. Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue. Panus, J.F., Smith, C.A., Ray, C.A., Smith, T.D., Patel, D.D., Pickup, D.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
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