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Gene Review: 

ZDHHC15  -  zinc finger, DHHC-type containing 15

Homo sapiens

Synonyms: DHHC-15, FLJ31812, MRX91, Palmitoyltransferase ZDHHC15, UNQ1969/PRO4501, ...
 
 
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Psychiatry related information on ZDHHC15

 

High impact information on ZDHHC15

  • Physical mapping of the breakpoints localised the Xq13.3 breakpoint to within 3.9 kb of the first exon of the ZDHHC15 gene encoding a zinc-finger and a DHHC domain containing product [1].
  • ZDHHC15-specific RT-PCR analysis on lymphocytes from the patient revealed an absence of ZDHHC15 transcript variants, detected in control samples [1].
  • We suggest that the absence of the ZDHHC15 transcripts in this patient contributes to her phenotype, and that the gene is a strong candidate for nonsyndromic XLMR [1].

References

  1. Loss of ZDHHC15 expression in a woman with a balanced translocation t(X;15)(q13.3;cen) and severe mental retardation. Mansouri, M.R., Marklund, L., Gustavsson, P., Davey, E., Carlsson, B., Larsson, C., White, I., Gustavson, K.H., Dahl, N. Eur. J. Hum. Genet. (2005) [Pubmed]
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