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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Khdrbs2  -  KH domain containing, RNA binding, signal...

Mus musculus

Synonyms: 6330586C16Rik, KH domain-containing, RNA-binding, signal transduction-associated protein 2, SLM-1, Sam68-like mammalian protein 1, Slim1, ...
 
 
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High impact information on Khdrbs2

  • SLM-1 is an RNA-binding protein that is tyrosine phosphorylated by Src during mitosis [1].
  • Together, our data suggest that Slm1 and Slm2 define a molecular link between phosphoinositide and sphingolipid signaling and thereby regulate actin cytoskeleton organization [2].
  • The phosphorylation of SLM-1 and SLM-2 has functional relevance and leads to inhibition of their RNA-binding abilities [3].

References

  1. Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis. Di Fruscio, M., Chen, T., Richard, S. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  2. The phosphatidylinositol 4,5-biphosphate and TORC2 binding proteins Slm1 and Slm2 function in sphingolipid regulation. Tabuchi, M., Audhya, A., Parsons, A.B., Boone, C., Emr, S.D. Mol. Cell. Biol. (2006) [Pubmed]
  3. The nuclear tyrosine kinase BRK/Sik phosphorylates and inhibits the RNA-binding activities of the Sam68-like mammalian proteins SLM-1 and SLM-2. Haegebarth, A., Heap, D., Bie, W., Derry, J.J., Richard, S., Tyner, A.L. J. Biol. Chem. (2004) [Pubmed]
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