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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Mtf2  -  metal response element binding...

Mus musculus

Synonyms: 9230112N11Rik, AA537621, C76717, M96, Metal regulatory transcription factor 2, ...
 
 
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High impact information on Mtf2

  • Interactions of the zinc-regulated factor (ZiRF1) with the mouse metallothionein Ia promoter [1].
  • Competition analysis of MRE-binding proteins from mouse NIH3T3 cells with oligonucleotide matching the binding sites for SP1 and MTF1 confirmed that both the basal SP1 and the metal-regulated MBC/ZiRF1 interact with the MREd/c region [1].
  • We observed a dose-dependent inhibition of the GST-ZiRF1/MRE-binding activity using three different metal chelators: EDTA, 1,10 PHE and TPEN [2].
  • The region containing this conserved motif is shared among members of the Polycomblike proteins that include the mouse M96 and Drosophila Polycomblike [3].
 

Biological context of Mtf2

 

Analytical, diagnostic and therapeutic context of Mtf2

  • In mouse L-cell nuclear extracts, mobility-shift assays revealed a Zn2+-dependent MRE-binding complex (MBC) with DNA-recognition properties similar to those of ZiRF1 [1].
  • Antibodies raised against purified GST-ZiRF1 were able to specifically recognize MBC in Western-blot analyses [1].

References

  1. Interactions of the zinc-regulated factor (ZiRF1) with the mouse metallothionein Ia promoter. Remondelli, P., Leone, A. Biochem. J. (1997) [Pubmed]
  2. Regulation of ZiRF1 and basal SP1 transcription factor MRE-binding activity by transition metals. Remondelli, P., Moltedo, O., Leone, A. FEBS Lett. (1997) [Pubmed]
  3. Tctex3, related to Drosophila polycomblike, is expressed in male germ cells and mapped to the mouse t-complex. Kawakami, S., Mitsunaga, K., Kikuti, Y.Y., Ando, A., Inoko, H., Yamamura, K., Abe, K. Mamm. Genome (1998) [Pubmed]
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