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Gene Review

pgp-1  -  Protein PGP-1

Caenorhabditis elegans

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High impact information on pgp-1


Biological context of pgp-1

  • A novel gene designated as fragile site-associated (FSA) gene was recently identified by positional cloning from the CHO 1q31 fragile site which plays an important role in regulating amplification of multidrug resistance (mdr1) gene in multidrug-resistant cells [5].
  • The issue of reversal of drug resistance is analysed under consideration of recent progress in the field of MDR reversal in non-infectious diseases [6].

Associations of pgp-1 with chemical compounds


  1. The expression of two P-glycoprotein (pgp) genes in transgenic Caenorhabditis elegans is confined to intestinal cells. Lincke, C.R., Broeks, A., The, I., Plasterk, R.H., Borst, P. EMBO J. (1993) [Pubmed]
  2. A missense mutation in Caenorhabditis elegans prohibitin 2 confers an atypical multidrug resistance. Zubovych, I., Doundoulakis, T., Harran, P.G., Roth, M.G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. The P-glycoprotein gene family of Caenorhabditis elegans. Cloning and characterization of genomic and complementary DNA sequences. Lincke, C.R., The, I., van Groenigen, M., Borst, P. J. Mol. Biol. (1992) [Pubmed]
  4. Modulation of the multidrug resistance (MDR) system in the nematode Haemonchus contortus by changing cholesterol content: effects on resistance to anthelmintics. Riou, M., Guégnard, F., Le Vern, Y., Kerboeuf, D. J. Antimicrob. Chemother. (2003) [Pubmed]
  5. Association of fragile site-associated (FSA) gene expression with epithelial differentiation and tumor development. Kuo, M.T., Wei, Y., Yang, X., Tatebe, S., Liu, J., Troncoso, P., Sahin, A., Ro, J.Y., Hamilton, S.R., Savaraj, N. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. Will technology provide solutions for drug resistance in veterinary helminths? von Samson-Himmelstjerna, G., Blackhall, W. Vet. Parasitol. (2005) [Pubmed]
  7. Fecal shedding and antimicrobial susceptibility of selected bacterial pathogens and a survey of intestinal parasites in free-living waterfowl. Fallacara, D.M., Monahan, C.M., Morishita, T.Y., Wack, R.F. Avian Dis. (2001) [Pubmed]
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