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Gene Review

pgp-3  -  Protein PGP-3

Caenorhabditis elegans

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Disease relevance of pgp-3

  • In contrast to pgp-3 mutants, nhr-8 mutants are not more sensitive than wild-type to pyocyanin-dependent killing by the pathogenic bacterium Pseudomonas aeruginosa [1].

High impact information on pgp-3

  • By transposon-mediated deletion mutagenesis we generated nematode strains with deleted P-glycoprotein genes and found that the pgp-3 deletion mutant, but not the pgp-1 mutant, is sensitive to both colchicine and chloroquine [2].
  • Expression of pgp-1 and pgp-3, as inferred from pgp-lacZ transgenic nematodes, was confined to the intestinal cells [3].


  1. A C. elegans orphan nuclear receptor contributes to xenobiotic resistance. Lindblom, T.H., Pierce, G.J., Sluder, A.E. Curr. Biol. (2001) [Pubmed]
  2. A P-glycoprotein protects Caenorhabditis elegans against natural toxins. Broeks, A., Janssen, H.W., Calafat, J., Plasterk, R.H. EMBO J. (1995) [Pubmed]
  3. The expression of two P-glycoprotein (pgp) genes in transgenic Caenorhabditis elegans is confined to intestinal cells. Lincke, C.R., Broeks, A., The, I., Plasterk, R.H., Borst, P. EMBO J. (1993) [Pubmed]
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