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Gene Review:

Mup3 - major urinary protein 3

Mus musculus

Synonyms: MUP 3, MUP15, MUPIII, Major urinary protein 3, Mup-3, ...

Noronha-Blob, L. et al., Ehlert, F.J. et al., Mizojiri, K. et al., Held, W.A. et al., Oda, W. et al.

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Disease relevance of Mup3

Enantiomers of oxybutynin: in vitro pharmacological characterization at M1, M2 and M3 muscarinic receptors and in vivo effects on urinary bladder contraction, mydriasis and salivary secretion in guinea pigs [1].

High impact information on Mup3

C57BL/6J MUP genomic clones encoding MUP 2 (BL6-25 and BL6-51), MUP 3 (BL6-11 and BL6-3), and MUP 4 (BL6-42) have been identified [2].
When measured in the absence of other agents, contractions elicited to the muscarinic agonist oxotremorine-M exhibited properties consistent with that expected for an M3 response in urinary bladder from wild-type and M2 knockout (KO) mice [3].
The affinity of (R)OXY and (S)OXY for different muscarinic receptor subtypes was determined using field stimulated rabbit vas deferens (M1) and guinea pig atria (M2) or bladder (M3) strips [1].
The MHV-72 DNA sequence was almost identical to MHV-68 except for approximately 7000 bp corresponding to the MHV-68 M1-M3 genes [4].
Hydroxylation of Am-80 to yield 7-hydroxy-Am-80 (M-4) and 6-hydroxy-Am-80 (M-3), which lead to the formation of 6-oxo-Am-80 (M-5), were commonly observed in all animal species [5].

References

Enantiomers of oxybutynin: in vitro pharmacological characterization at M1, M2 and M3 muscarinic receptors and in vivo effects on urinary bladder contraction, mydriasis and salivary secretion in guinea pigs. Noronha-Blob, L., Kachur, J.F. J. Pharmacol. Exp. Ther. (1991) [Pubmed]
Identification and characterization of functional genes encoding the mouse major urinary proteins. Held, W.A., Gallagher, J.F., Hohman, C.M., Kuhn, N.J., Sampsell, B.M., Hughes, R.G. Mol. Cell. Biol. (1987) [Pubmed]
The M2 muscarinic receptor mediates contraction through indirect mechanisms in mouse urinary bladder. Ehlert, F.J., Griffin, M.T., Abe, D.M., Vo, T.H., Taketo, M.M., Manabe, T., Matsui, M. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
Analysis of genomic homology of murine gammaherpesvirus (MHV)-72 to MHV-68 and impact of MHV-72 on the survival and tumorigenesis in the MHV-72-infected CB17 scid/scid and CB17+/+ mice. Oda, W., Mistrikova, J., Stancekova, M., Dutia, B.M., Nash, A.A., Takahata, H., Jin, Z., Oka, T., Hayashi, K. Pathol. Int. (2005) [Pubmed]
Studies on the metabolism and disposition of the new retinoid 4-[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)carbamoyl] benzoic acid. 4th communication: absorption, metabolism, excretion and plasma protein binding in various animals and man. Mizojiri, K., Okabe, H., Sugeno, K., Misaki, A., Ito, M., Kominami, G., Esumi, Y., Takaichi, M., Harada, T., Seki, H., Inaba, A. Arzneimittel-Forschung. (1997) [Pubmed]

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